22-Day South America & Antarctica

The 22-Day South America & Antarctica is a 22-night South America cruise aboard Nieuw Amsterdam, operated by Holland America Line. Departing Buenos Aires on December 17, 2027, the voyage visits 11 ports. Fares start from $6,479 per person.

Length: 22 nights
Departs: Dec 17, 2027
Returns: Jan 8, 2028
Ports of call: 11
Days at sea: 9

from $6,479

$294 / night per person, incl. taxes & fees

Book with CruiseDirect Book direct with Holland America Line

We may earn a commission

from $6,479 pp

via CruiseDirect

Book

Book direct with Holland America Line we may earn a commission

Itinerary

Day 1 Jan 30, 2028 Buenos Aires Passionate, and alive with an infectious crackling energy, the Argentine capital is a breathlessly romantic city, which blends old-world colonial architecture with a down-to-earth Latin American clamour. Famed for steamy tango interplays, and expertly seared steak slabs, a visit to Buenos Aires is a fiery fiesta for the senses. Parque Tres de Febrero is a 400-hectare oasis where 18,000 rose bushes bloom, and skyscrapers give way to still lakes and pretty paths of rollerblading locals. Mighty palm trees - that look like exploding fireworks - stand tall in Plaza de Mayo, the heart of this sprawling cosmopolitan capital of 48 barrios. The square has served as the stage for many fundamental events in this country’s history, and the location where the seeds of independence were sewn continues to serve as the city’s gathering point - and is a place for solidarity, rebellion and revolution. The presidential Casa Rosada’s salmon-hued Palatial Palace borders the plaza, while nearby Museum Nacional de Bellas Artes houses the largest collection of public art in Latin America. Teatro Colón, the opulent 1908 opera house, is one of the world’s finest venues - musical performance here take on an ethereal quality, with the exceptional acoustics transferring every quiver of bow, and tremor of vocal cord, to the audience in spine-tingling clarity. The gargantuan, precipitous terraces of Bombonera Stadium form another of Buenos Aires’s incredible venues, and a wall of noise emanates from it when Boca Juniors take to the field. Juicy steak and punchy Malbec flow in the city’s parrillas – steakhouses - while glitzy bars and thumping nightclubs welcome revellers late into the night. It’s not just the meat that sizzles here either - tango dancers fill milongas - dance halls - to strut passionately until the early hours. Sip steaming mate, the country’s national drink, shop in covered markets, and explore Cementerio de la Recoleta - a city of grand graves and intricate memorials honouring presidents, politicians and notable Argentine heroes from history. Buenos Aires port guide Search cruises visiting Buenos Aires

Buenos Aires photo — Day 1 Jan 30, 2028 Buenos Aires Passionate, and alive with an infectious crackling energy, the Argentine capital is a breathlessly romantic city, which blends old-world colonial architecture with a down-to-earth Latin American clamour. Famed for steamy tango interplays, and expertly seared steak slabs, a visit to Buenos Aires is a fiery fiesta for the senses. Parque Tres de Febrero is a 400-hectare oasis where 18,000 rose bushes bloom, and skyscrapers give way to still lakes and pretty paths of rollerblading locals. Mighty palm trees - that look like exploding fireworks - stand tall in Plaza de Mayo, the heart of this sprawling cosmopolitan capital of 48 barrios. The square has served as the stage for many fundamental events in this country’s history, and the location where the seeds of independence were sewn continues to serve as the city’s gathering point - and is a place for solidarity, rebellion and revolution. The presidential Casa Rosada’s salmon-hued Palatial Palace borders the plaza, while nearby Museum Nacional de Bellas Artes houses the largest collection of public art in Latin America. Teatro Colón, the opulent 1908 opera house, is one of the world’s finest venues - musical performance here take on an ethereal quality, with the exceptional acoustics transferring every quiver of bow, and tremor of vocal cord, to the audience in spine-tingling clarity. The gargantuan, precipitous terraces of Bombonera Stadium form another of Buenos Aires’s incredible venues, and a wall of noise emanates from it when Boca Juniors take to the field. Juicy steak and punchy Malbec flow in the city’s parrillas – steakhouses - while glitzy bars and thumping nightclubs welcome revellers late into the night. It’s not just the meat that sizzles here either - tango dancers fill milongas - dance halls - to strut passionately until the early hours. Sip steaming mate, the country’s national drink, shop in covered markets, and explore Cementerio de la Recoleta - a city of grand graves and intricate memorials honouring presidents, politicians and notable Argentine heroes from history. Buenos Aires port guide Search cruises visiting Buenos Aires

Day 3 Feb 1, 2028 Montevideo Arrives 08:00 As you sail on an MSC cruise to South America, Montevideo is the port for you. Founded in 1726 as a fortress against Portuguese encroachment on the northern shore of the Río de la Plata, it had an excellent trading position and, following a turbulent and often violent early history, its growth was rapid. A shore excursion on your MSC South America cruise can be the opportunity to discover Montevideo. It may appear humble at first, but this is a seriously cool, confident city. If you’ve ever seen a fictionalized version of Havana on TV or film, it’s quite possible it was actually shot in Montevideo’s Ciudad Vieja, so reminiscent are its streets of those in the Cuban capital. Dotted among the crumbling houses and cobbled streets are endearingly bizarre (and mostly free) museums and galleries, while the highlight is the glorious Mercado del Puerto. A good place to start a walking tour of the Ciudad Vieja is the Puerta de la Ciudadela, dating to 1746, marking the original site of the Citadel of Montevideo on the Plaza Independencia. This square commemorates the emergence of Uruguay as a sovereign nation, and a 17m-high statue and mausoleum of José Artigas, the man credited with kick-starting Uruguay’s independence campaign against Spain and Portugal, stands aptly in the centre. The area around the plaza contains eclectic architectural styles from different periods, from the Torre Ejecutiva where the president performs his duties, to the bulbous tower of the Palacio Salvo, built on the reported site of the first ever performance of tango. Tucked behind the plaza’s south-western corner is the celebrated Teatro Solís, the most prestigious theatre in the country, completed in 1856 and remodelled a few times thereafter. Montevideo port guide Search cruises visiting Montevideo

Day 6 Feb 4, 2028 Puerto Madryn 09:00 – 17:00 8.0 hrs ashore Puerto Madryn, where you will stop on your MSC World Cruise, is on the shores of the beautiful and protected Nuevo Gulf. The city is the gateway to the incredible Ecocentro, east of the city, an ecological treasure of the Valdés Peninsula where you can discover the rich marine life in the area. The Welsh landed here for the first time in 1865, but development was slow until the arrival of the railway two decades later, when Puerto Madryn became the port for the villages in the lower Valley of the Chubut River. The Parque Histórico Punta Cuevas marks the first Welsh settlement in Patagonia with the Monumento al Indio Tehuelche, a statue that celebrates the centenary of the arrival of the Welsh and pays homage to the Tehuelche. From here you can enjoy breathtaking views of the Nuevo Golf at sunset, lit up by the lights of the city. Along the promontory lies Puerto Madryn’s most important attraction, the outstanding Ecocentre. This interactive museum promotes awareness and respect for marine ecosystems. You can take an MSC day trip to go dolphin and sea lion watching out at sea, or to visit the Valdés Peninsula and Punta Tombo. The Valdés Peninsula is one of the most important marine reserves in the world, recognised as a UNESCO World Heritage Site in 1999. Nothing can prepare you for the amazing richness of the marine environment that surrounds it – and in particular the southern right whales which migrate here every year to swim in the waters off the town of Puerto Pirámides – nor for the immense colonies of animals living on the Peninsula’s steep, crumbly cliffs. Punta Tombo is home to the continent's largest colonyof penguins; the noise produced by the black and white Magellanic penguins is deafening, but walking through this avian metropolis, surrounded by the strangest sounds and tottering birds is a unique experience. This is just one of the fantastic destinations of our cruise around the world: MSC World Cruise 2020! Puerto Madryn port guide Search cruises visiting Puerto Madryn

Puerto Madryn photo — Day 6 Feb 4, 2028 Puerto Madryn 09:00 – 17:00 8.0 hrs ashore Puerto Madryn, where you will stop on your MSC World Cruise, is on the shores of the beautiful and protected Nuevo Gulf. The city is the gateway to the incredible Ecocentro, east of the city, an ecological treasure of the Valdés Peninsula where you can discover the rich marine life in the area. The Welsh landed here for the first time in 1865, but development was slow until the arrival of the railway two decades later, when Puerto Madryn became the port for the villages in the lower Valley of the Chubut River. The Parque Histórico Punta Cuevas marks the first Welsh settlement in Patagonia with the Monumento al Indio Tehuelche, a statue that celebrates the centenary of the arrival of the Welsh and pays homage to the Tehuelche. From here you can enjoy breathtaking views of the Nuevo Golf at sunset, lit up by the lights of the city. Along the promontory lies Puerto Madryn’s most important attraction, the outstanding Ecocentre. This interactive museum promotes awareness and respect for marine ecosystems. You can take an MSC day trip to go dolphin and sea lion watching out at sea, or to visit the Valdés Peninsula and Punta Tombo. The Valdés Peninsula is one of the most important marine reserves in the world, recognised as a UNESCO World Heritage Site in 1999. Nothing can prepare you for the amazing richness of the marine environment that surrounds it – and in particular the southern right whales which migrate here every year to swim in the waters off the town of Puerto Pirámides – nor for the immense colonies of animals living on the Peninsula’s steep, crumbly cliffs. Punta Tombo is home to the continent's largest colonyof penguins; the noise produced by the black and white Magellanic penguins is deafening, but walking through this avian metropolis, surrounded by the strangest sounds and tottering birds is a unique experience. This is just one of the fantastic destinations of our cruise around the world: MSC World Cruise 2020! Puerto Madryn port guide Search cruises visiting Puerto Madryn

Day 10 Feb 8, 2028 Antarctica 08:00 – 18:00 10.0 hrs ashore The Antarctic Peninsula unravels upwards towards South America, reaching out a beckoning finger to the adventurous, who dare to explore this untamed realm. Stretching up from the heart of the world’s southernmost continent, the Antarctic Peninsula lies a mere 620 mile from Tierra del Fuego and, for many, offers a spectacular first taste of the snow-blanketed landscapes and colossal ice sculptures, which make up Earth’s least-explored continent. Unseen by humans until 1820 - a blink of an eye ago in relative terms - this is an adventure sure to make your hairs stand on end, as you experience the thrill of the truly unknown and extraordinary. The vast peninsula is sprinkled with research bases, which are at the frontline of human scientific endeavour, pushing to study and understand this unique landscape, its exceptional wildlife, and the impact that humans are having on this pristine continent. Witness cathedral-sized icebergs up close, and blue-hued glaciers, slowly slipping from imposing locations like Hope Bay. Blanched mountain peaks cover the peninsula, and you’ll find thousands of adorable Adelie penguin pairs thriving undisturbed in this peninsula’s unique setting. Antarctica port guide Search cruises visiting Antarctica

Antarctica photo — Day 10 Feb 8, 2028 Antarctica 08:00 – 18:00 10.0 hrs ashore The Antarctic Peninsula unravels upwards towards South America, reaching out a beckoning finger to the adventurous, who dare to explore this untamed realm. Stretching up from the heart of the world’s southernmost continent, the Antarctic Peninsula lies a mere 620 mile from Tierra del Fuego and, for many, offers a spectacular first taste of the snow-blanketed landscapes and colossal ice sculptures, which make up Earth’s least-explored continent. Unseen by humans until 1820 - a blink of an eye ago in relative terms - this is an adventure sure to make your hairs stand on end, as you experience the thrill of the truly unknown and extraordinary. The vast peninsula is sprinkled with research bases, which are at the frontline of human scientific endeavour, pushing to study and understand this unique landscape, its exceptional wildlife, and the impact that humans are having on this pristine continent. Witness cathedral-sized icebergs up close, and blue-hued glaciers, slowly slipping from imposing locations like Hope Bay. Blanched mountain peaks cover the peninsula, and you’ll find thousands of adorable Adelie penguin pairs thriving undisturbed in this peninsula’s unique setting. Antarctica port guide Search cruises visiting Antarctica

Day 16 Feb 14, 2028 Ushuaia, Argentina 09:00 – 15:30 6.5 hrs ashore Ushuaia, capital of Tierra del Fuego and the province’s main tourist hub, is located at the southern end of Isla Grande. Boasting a spectacular location, sandwiched between the mountains – including Cerro Martial and Mount Olivia – and the sea, Ushuaia extends down the hill towards the arm of land that surrounds the Bay, where the ship will stop during your MSC WorldCruise. The city is protected from the icy Southwest winds and occasional storms that occur in the Beagle Channel. Interesting excursions include the small islands in the middle of the channel in front of the city, with their colonies of seabirds, and the nearby Parque Nacional Tierra del Fuego. Ushuaia is the most populous and popular city in Tierra del Fuego, and depends largely on the thriving tourism industry, which capitalises on the beauty of the area’s natural landscapes. Overlooking the sea is the Antigua Casa de Gobierno, a late-20th century building that was originally the Governor's mansion before being used by the local government and then as a police station. It has been restored so as to return it to its original use, so you can get an idea of how the rich lived in Ushuaia at the dawn of the city. The Fin del Mundo Museum houses exhibitions that focus on the region’s history and wildlife, as well as the polychrome figurehead of the Duchess of Albany, an English ship wrecked on the eastern end of the island in 1883. The Parque Nacional Tierra del Fuego, 12 km west of Ushuaia, is 630 sq. km of rugged mountains, sinuous lakes, southern beech forests, marshy bogs, sub-Antarctic tundra and lush coasts. It extends along the border with Chile, from the Beagle Channel to Sierra Inju-Goiyin, north of the huge Lake Fagnano, which you can also visit on an MSC Cruise day trip, combined with Lake Escondido. This is just one of the fantastic destinations of our cruise around the world: MSC World Cruise 2020! Ushuaia, Argentina port guide Search cruises visiting Ushuaia, Argentina

Day 17 Feb 15, 2028 Punta Arenas, Chile 10:00 – 22:00 12.0 hrs ashore As we head back towards land, a statue of fellow explorer Ferdinand Magellan greets us. Located on the western side of the Strait of Magellan, Punta Arenas is the capital of Chile's Magallanes Region and the bustling centre base for South Atlantic fishing boats and Antarctic research vessels. This busy port town is a melding of cultures from the English sheep ranchers to Portuguese sailors, all of which are a symbol of Chile's rich history. Punta Arenas' city centre features impressive mansions dating from the late 19th and early 20th centuries. In 1982, Isla Magdalena was declared a Chilean Natural Monument. Residing in the Magellan Straits, it serves as a bird sanctuary specifically to the Magellanic penguins, who share their nesting area with cormorants amongst other seabirds and sea lions. We explore the island together with our ship staff, and learn more about these naturally curious and untamed creatures. However, simply watching 150,000 burrowing penguins share chores with their lifelong mates is quite amazing. Each morning and afternoon, the fishing penguins return to shore to switch places with their mate who has been taking care of the young. These same penguins return every year between October and March to lay eggs and raise their young. Punta Arenas, Chile port guide Search cruises visiting Punta Arenas, Chile

Day 17 Feb 15, 2028 Magellan Strait This 360-mile strait isolates the Tierra del Fuego archipelago from the rest of the South American continent, and is named after the ambitious Portuguese explorer and mariner Ferdinand Magellan. You'll retrace Magellan's route as you make the shortest crossing from Atlantic to Pacific between two land masses this side of the Panama Canal. Magellan Strait port guide Search cruises visiting Magellan Strait

Magellan Strait photo — Day 17 Feb 15, 2028 Magellan Strait This 360-mile strait isolates the Tierra del Fuego archipelago from the rest of the South American continent, and is named after the ambitious Portuguese explorer and mariner Ferdinand Magellan. You'll retrace Magellan's route as you make the shortest crossing from Atlantic to Pacific between two land masses this side of the Panama Canal. Magellan Strait port guide Search cruises visiting Magellan Strait

Day 20 Feb 18, 2028 Puerto Chacabuco, Chile 07:00 – 15:00 8.0 hrs ashore South of Puerto Montt, surrounded by majestic fjords, Puerto Chacabuco looks more like Norway than Northwest Patagonia. The town’s history as an important fishing village still holds true today. And with a population of just 1,200, Azamara® guests can expect a truly immersive experience on shore. Plunging waterfalls. Fathomless gorges. Dramatic coastlines. Puerto Chacabuco is your gateway to some of Chile’s most stunning natural wonders. Don’t miss the Río Simpson National Preserve: a protected park that boasts all three; plus, some of the best fly fishing in the world. A visit to Aiken del Sur Private Park promises the same, with an enchanting opportunity to get back to nature at serene Lake Riesco.

Puerto Montt photo — Day 21 Feb 19, 2028 Puerto Montt 08:00 – 17:00 9.0 hrs ashore Established in the 1850s by German settlers, Puerto Montt is beautifully situated on the Seno de Reloncaví (Strait of Reloncaví) – where your MSC cruise ship awaits you –, with snowcapped mountains clearly visible beyond the sound on a good day and the Osorno vulcan behind. Puerto Montt is a large, busy city with traffic-choked streets. The town stretches along the bay, with Avenida Diego Portales running east along the seafront towards the Plaza de Armas – the centre, surrounded by banks, cheap bars and restaurants. West of the main bus terminal, Avenida Costanera takes you to the busy passenger port with a feria artesanal (craft market) and the Angelmó fishing district. While enjoying your MSC World Cruise, you can take day trips from Puerto Montt to Puerto Varas. Dominating the southwestern corner of the lake, it has become a popular resort town and backpacker haunt, with unparalleled sunset views of the two nearby volcanoes, Osorno and Calbuco. Rivalling Pucón in terms of nearby outdoor attractions, Puerto Varas does not feel too crowded despite its popularity, and makes an excellent base for volcano-climbing, white-water rafting, kayaking and cycling. Though the town is spread out over 3km of lakefront, most services, hostels and restaurants are located within a couple of blocks of the little Plaza de Armas. The town’s German colonial architecture gives it a European feel, and notable early twentieth century buildings like the Iglesia del Sagrado Corazón de Jesús (1915-18) and private residences include Casa Kuschel, on Klenner 299 (1910), Casona Alemana (1914) at Nuestra Señora del Carmen 788 and Casa Angulo (1910) at Miraflores 96. This is just one of the fantastic destinations of our cruise around the world:MSC World Cruise 2020! Puerto Montt port guide Search cruises visiting Puerto Montt

Day 23 Feb 21, 2028 San Antonio, Chile Arrives 07:00 Nestled between the Andes and the Pacific Ocean, energetic Santiago de Chile offers surprising discoveries with its renovated arts scene, expansive museums and noteworthy restaurants you won’t want to miss. Take in the outstanding views of this cosmopolitan capital by biking or hiking up one of its many gorgeous hills. Visit the Plaza de Armas – Santiago’s Original City Center – where you’ll be able to see a wealth of historical buildings and grand architecture. Or get a glimpse into the private and professional life of the poet and Nobel Prize winner Pablo Neruda by visiting one of his homes, all three of which have been converted into museums.

Pricing

Lowest fare we've tracked over the observed 80-day span: $6,294 · range $6,294–$6,479

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $6,479

$294 / night

Fare rows

Standard Interior Stateroom

Cabin grade

Available

from $6,479

$294 / night

per person · incl. taxes

Standard Interior Stateroom

Cabin grade

Available

from $6,599

$299 / night

per person · incl. taxes

Standard Interior Stateroom

Cabin grade

Available

from $6,659

$302 / night

per person · incl. taxes

Standard Interior Stateroom

Cabin grade

Available

from $6,719

$305 / night

per person · incl. taxes

Large/Standard Inside Stateroom

Cabin grade

Available

from $6,779

$308 / night

per person · incl. taxes

Large/Standard Inside Stateroom

Cabin grade

Available

from $6,839

$310 / night

per person · incl. taxes

Large Interior Stateroom

Cabin grade

Available

from $6,899

$313 / night

per person · incl. taxes

Interior Spa Stateroom

Cabin grade

Available

from $6,959

$316 / night

per person · incl. taxes

Oceanview

from $6,879

$312 / night

Fare rows

Large Ocean view Stateroom (Fully Obstructed View)

Cabin grade

Available

from $6,879

$312 / night

per person · incl. taxes

Large Ocean view Stateroom (Fully Obstructed View)

Cabin grade

Available

from $6,999

$318 / night

per person · incl. taxes

Large Ocean view Stateroom (Partial Sea View)

Cabin grade

Available

from $7,089

$322 / night

per person · incl. taxes

Large Ocean view Stateroom

Cabin grade

Available

from $7,579

$344 / night

per person · incl. taxes

Large Ocean view Stateroom

Cabin grade

Available

from $7,699

$349 / night

per person · incl. taxes

Large Ocean view Stateroom

Cabin grade

Available

from $7,789

$354 / night

per person · incl. taxes

Large Ocean view Stateroom

Cabin grade

Available

from $7,879

$358 / night

per person · incl. taxes

Large Ocean view Stateroom

Cabin grade

Available

from $7,969

$362 / night

per person · incl. taxes

Large Ocean view Spa Stateroom

Cabin grade

Available

from $8,059

$366 / night

per person · incl. taxes

Balcony

from $8,979

$408 / night

Fare rows

Verandah Stateroom

Cabin grade

Available

from $8,979

$408 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $9,179

$417 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $9,319

$423 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $9,459

$429 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $9,599

$436 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $9,739

$442 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $9,879

$449 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $10,019

$455 / night

per person · incl. taxes

Verandah Spa Stateroom

Cabin grade

Available

from $10,159

$461 / night

per person · incl. taxes

Suite

from $11,979

$544 / night

Fare rows

Signature Suite

Cabin grade

Available

from $11,979

$544 / night

per person · incl. taxes

Signature Suite

Cabin grade

Available

from $12,579

$571 / night

per person · incl. taxes

Signature Suite

Cabin grade

Available

from $13,179

$599 / night

per person · incl. taxes

Neptune Suite

Cabin grade

Available

from $15,479

$703 / night

per person · incl. taxes

Neptune Suite

Cabin grade

Available

from $16,289

$740 / night

per person · incl. taxes

Neptune Suite

Cabin grade

Available

from $17,099

$777 / night

per person · incl. taxes

Neptune Spa Suite

Cabin grade

Available

from $17,909

$814 / night

per person · incl. taxes

Prices verified Jun 24, 2026

Prices come from third-party data feeds via Holland America Line and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

Show all 34 cabin grades

Name	Supplier code	Type
Verandah Stateroom	V	Balcony
Verandah Stateroom	VA	Balcony
Verandah Stateroom	VB	Balcony
Verandah Stateroom	VC	Balcony
Verandah Stateroom	VD	Balcony
Verandah Stateroom	VE	Balcony
Verandah Stateroom	VF	Balcony
Verandah Stateroom	VH	Balcony
Verandah Spa Stateroom	VQ	Balcony
Large Interior Stateroom	I	Inside
Interior Spa Stateroom	IQ	Inside
Large/Standard Inside Stateroom	J	Inside
Large/Standard Inside Stateroom	K	Inside
Standard Interior Stateroom	L	Inside
Standard Interior Stateroom	M	Inside
Standard Interior Stateroom	MM	Inside
Standard Interior Stateroom	N	Inside
Large Ocean view Stateroom	C	Oceanview
Large Ocean view Spa Stateroom	CQ	Oceanview
Large Ocean view Stateroom	D	Oceanview
Large Ocean view Stateroom	DD	Oceanview
Large Ocean view Stateroom	E	Oceanview
Large Ocean view Stateroom	F	Oceanview
Large Ocean view Stateroom (Partial Sea View)	G	Oceanview
Large Ocean view Stateroom (Fully Obstructed View)	H	Oceanview
Large Ocean view Stateroom (Fully Obstructed View)	HH	Oceanview
Pinnacle Suite	PS	Suite
Neptune Suite	SA	Suite
Neptune Suite	SB	Suite
Neptune Suite	SC	Suite
Neptune Spa Suite	SQ	Suite
Signature Suite	SS	Suite
Signature Suite	SY	Suite
Signature Suite	SZ	Suite