South America cruises
Compare South America sailings by cruise line, ship, departure date, port, and price.
South America cruises reward adventurous travellers with spectacular scenery and cultural depth. Watch the spectacle of Rio de Janeiro glide by from the sea, transit the majestic Magellan Strait, marvel at the calving glaciers of Patagonia, and explore the colonial grandeur of Buenos Aires. Cape Horn and the Amazon River offer some of the world's most remote and dramatic waterways.
Known for: Patagonia Glaciers · Amazon River · Rio de Janeiro · Buenos Aires · Cape Horn
Itineraries across South America's cruise lines
4 itineraries with multiple South America ports.
Grandeur of the Seas
7 nights · Sep 26, 2026
Cartagena, Colombia, Colon, Panama, Oranjestad, Aruba, Willemstad, Curacao
from $745
$106 / night
MSC Musica
7 nights · Feb 27, 2027
Buzios, Ilhabela, Ilha Grande, Brazil, Itajai + 2 more
from $701
$100 / night
Costa Diadema
4 nights · Mar 27, 2027
Ilhabela, Itajai, Santos, Brazil
from $675
$168 / night
South America cruises
Prices per person · incl. taxes & fees.
Lowest per-night among the least expensive fares — 13 nights on MSC Musica at $57/night per person.Cruise lines sailing in South America
Ports in South America
Showing 1,607 South America cruises
Open in full search| View | Ship image | Cruise line | Line / Ship | Departs | Nights | From |
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Dec 1, 2026 | 1 |
from $70 |
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Mar 17, 2027 | 3 |
from $473 $157 / night |
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Sep 26, 2026 | 7 |
from $745 $106 / night |
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Apr 1, 2027 | 1 |
from $79 |
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Dec 2, 2026 | 3 |
from $503 $167 / night |
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Sep 12, 2026 | 7 |
from $810 $115 / night |
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Mar 14, 2027 | 1 |
from $79 |
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Mar 24, 2027 | 3 |
from $545 $181 / night |
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Aug 29, 2026 | 7 |
from $884 $126 / night |
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Apr 3, 2027 | 1 |
from $89 |
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Nov 23, 2026 | 2 |
from $551 $275 / night |
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Feb 26, 2028 | 7 |
from $886 $126 / night |
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Nov 15, 2026 | 1 |
from $103 |
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Dec 9, 2026 | 3 |
from $553 $184 / night |
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Feb 19, 2028 | 7 |
from $887 $126 / night |
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Mar 14, 2027 | 1 |
from $189 |
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Dec 16, 2026 | 3 |
from $553 $184 / night |
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Jan 8, 2028 | 7 |
from $908 $129 / night |
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Nov 23, 2026 | 3 |
from $363 $121 / night |
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Mar 20, 2027 | 4 |
from $591 $147 / night |
