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Panama City
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Cruises departing from Panama City

52 sailings depart from Panama City

You probably can’t think of Panama City without conjuring images of the Panama Canal. But nearly 400 years before the Panama Canal opened its locks, Panama City was making its mark. From the vestiges of the original settlement to the modern skyscrapers, experience the history and culture of one of the Pacific Coast’s oldest continuously inhabited European settlements. After exploring the bustling local markets in search of fresh fish or artisan handicrafts, admire the restored Spanish Colonial architecture in Casco Viejo. Or you can head to the Miraflores Locks and watch one of the modern world’s most heroic feats of engineering in action.

Departure port facts

Departure port facts
Country Panama
Departing cruises 52

Cruises from Panama City

Prices per person · incl. taxes & fees.

Showing 52 cruises from Panama City

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Upcoming cruises from this port
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Oceania Cruises line guide Search cruises from Panama City on Oceania Cruises Marina ship guide Search cruises on Marina Jan 16, 2028 10 Mexico

from $3,099

$309 / night
Oceania Cruises line guide Search cruises from Panama City on Oceania Cruises Marina ship guide Search cruises on Marina Mar 15, 2028 10 Mexico

from $3,149

$314 / night
Oceania Cruises line guide Search cruises from Panama City on Oceania Cruises Marina ship guide Search cruises on Marina Mar 15, 2027 10 Caribbean

from $3,899

$389 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Oct 31, 2026 7 Panama Canal

from $3,500

$500 / night
Scenic Ocean Cruises line guide Search cruises from Panama City on Scenic Ocean Cruises Scenic Eclipse ship guide Search cruises on Scenic Eclipse Oct 26, 2026 9 Transatlantic

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Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Nov 7, 2026 7 Panama Canal

from $10,600

$1,514 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Dec 20, 2026 7 Panama Canal

from $7,630

$1,090 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Dec 6, 2026 7 Panama Canal

from $12,500

$1,785 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Dec 13, 2026 7 Panama Canal

from $6,000

$857 / night
Regent Seven Seas Cruises line guide Search cruises from Panama City on Regent Seven Seas Cruises Seven Seas Splendor ship guide Search cruises on Seven Seas Splendor Jan 26, 2027 28 Mexico

from $22,399

$799 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Jan 3, 2027 7 Panama Canal

from $9,000

$1,285 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Jan 29, 2027 7 Panama Canal

from $16,000

$2,285 / night
Oceania Cruises line guide Search cruises from Panama City on Oceania Cruises Marina ship guide Search cruises on Marina Jan 15, 2027 10 Caribbean

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Regent Seven Seas Cruises line guide Search cruises from Panama City on Regent Seven Seas Cruises Seven Seas Prestige ship guide Search cruises on Seven Seas Prestige Feb 22, 2027 11 Caribbean

from $11,899

$1,081 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Feb 6, 2027 7 Panama Canal

from $18,500

$2,642 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Feb 20, 2027 7 Panama Canal

from $18,500

$2,642 / night
Regent Seven Seas Cruises line guide Search cruises from Panama City on Regent Seven Seas Cruises Seven Seas Grandeur ship guide Search cruises on Seven Seas Grandeur Mar 31, 2027 14 Caribbean

from $9,749

$696 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Mar 6, 2027 7 Panama Canal

from $18,500

$2,642 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Mar 20, 2027 7 Panama Canal

from $16,000

$2,285 / night
Scenic Ocean Cruises line guide Search cruises from Panama City on Scenic Ocean Cruises Scenic Eclipse II ship guide Search cruises on Scenic Eclipse II Apr 3, 2027 11 Caribbean

from $10,089

$917 / night
Scenic Ocean Cruises line guide Search cruises from Panama City on Scenic Ocean Cruises Scenic Eclipse ship guide Search cruises on Scenic Eclipse Oct 31, 2027 13 South America

from $13,869

$1,066 / night
Scenic Ocean Cruises line guide Search cruises from Panama City on Scenic Ocean Cruises Scenic Eclipse ship guide Search cruises on Scenic Eclipse Oct 31, 2027 25 South America

from $34,867

$1,394 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Nov 12, 2027 7 Panama Canal

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Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Nov 19, 2027 7 Panama Canal

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Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Nov 5, 2027 7 Panama Canal

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Oceania Cruises line guide Search cruises from Panama City on Oceania Cruises Nautica ship guide Search cruises on Nautica Dec 12, 2027 11 Caribbean

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Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Jan 29, 2028 7 Panama Canal

from $12,300

$1,757 / night
Hapag-Lloyd Cruises line guide Search cruises from Panama City on Hapag-Lloyd Cruises MS EUROPA 2 ship guide Search cruises on MS EUROPA 2 Jan 7, 2028 13 Caribbean

from $10,914

$839 / night
Hapag-Lloyd Cruises line guide Search cruises from Panama City on Hapag-Lloyd Cruises MS EUROPA 2 ship guide Search cruises on MS EUROPA 2 Jan 20, 2028 19 Caribbean

from $14,651

$771 / night
Emerald Yacht Cruises line guide Search cruises from Panama City on Emerald Yacht Cruises Emerald Azzurra ship guide Search cruises on Emerald Azzurra Jan 13, 2028 11 Caribbean

from $10,296

$936 / night
Oceania Cruises line guide Search cruises from Panama City on Oceania Cruises Nautica ship guide Search cruises on Nautica Feb 4, 2028 10 Caribbean

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Emerald Yacht Cruises line guide Search cruises from Panama City on Emerald Yacht Cruises Emerald Azzurra ship guide Search cruises on Emerald Azzurra Feb 29, 2028 11 Caribbean

from $10,296

$936 / night
Regent Seven Seas Cruises line guide Search cruises from Panama City on Regent Seven Seas Cruises Seven Seas Prestige ship guide Search cruises on Seven Seas Prestige Mar 14, 2028 12 Caribbean

from $7,699

$641 / night
Regent Seven Seas Cruises line guide Search cruises from Panama City on Regent Seven Seas Cruises Seven Seas Prestige ship guide Search cruises on Seven Seas Prestige Mar 14, 2028 26 Caribbean

from $17,499

$673 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Mar 9, 2028 7 Panama Canal

from $13,500

$1,928 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Mar 16, 2028 7 Panama Canal

from $13,500

$1,928 / night
Regent Seven Seas Cruises line guide Search cruises from Panama City on Regent Seven Seas Cruises Seven Seas Grandeur ship guide Search cruises on Seven Seas Grandeur Mar 9, 2027 22 South America

from $25,449

$1,156 / night
Scenic Ocean Cruises line guide Search cruises from Panama City on Scenic Ocean Cruises Scenic Eclipse ship guide Search cruises on Scenic Eclipse Oct 24, 2028 36 South America

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Scenic Ocean Cruises line guide Search cruises from Panama City on Scenic Ocean Cruises Scenic Eclipse ship guide Search cruises on Scenic Eclipse Oct 24, 2028 14 South America

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Emerald Yacht Cruises line guide Search cruises from Panama City on Emerald Yacht Cruises Emerald Azzurra ship guide Search cruises on Emerald Azzurra Jan 24, 2029 7 Panama Canal

from $7,677

$1,096 / night
Oceania Cruises line guide Search cruises from Panama City on Oceania Cruises Sonata ship guide Search cruises on Sonata Feb 11, 2029 11 Caribbean

from $5,699

$518 / night
Oceania Cruises line guide Search cruises from Panama City on Oceania Cruises Vista ship guide Search cruises on Vista Jan 19, 2029 12 Mexico

from $4,999

$416 / night
Emerald Yacht Cruises line guide Search cruises from Panama City on Emerald Yacht Cruises Emerald Azzurra ship guide Search cruises on Emerald Azzurra Jan 24, 2028 7 Panama Canal

from $5,460

$780 / night
Emerald Yacht Cruises line guide Search cruises from Panama City on Emerald Yacht Cruises Emerald Azzurra ship guide Search cruises on Emerald Azzurra Jan 13, 2029 11 Caribbean

from $10,647

$967 / night
Emerald Yacht Cruises line guide Search cruises from Panama City on Emerald Yacht Cruises Emerald Azzurra ship guide Search cruises on Emerald Azzurra Mar 1, 2029 11 Caribbean

from $10,647

$967 / night
Aurora Expeditions line guide Search cruises from Panama City on Aurora Expeditions Douglas Mawson ship guide Search cruises on Douglas Mawson Oct 4, 2027 9 Antarctica

from $9,196

$1,021 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Dec 4, 2027 7 Panama Canal

from $15,000

$2,142 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Dec 23, 2027 7 Panama Canal

from $14,500

$2,071 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Jan 6, 2028 7 Panama Canal

from $13,600

$1,942 / night
Lindblad Expeditions line guide Search cruises from Panama City on Lindblad Expeditions National Geographic Quest ship guide Search cruises on National Geographic Quest Feb 19, 2028 7 Panama Canal

from $15,000

$2,142 / night
View all 52 cruises →
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