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21-night South America cruise: San Diego, California to San Antonio, Chile on Nieuw Amsterdam

The 21-Day Inca Coast Discovery Segment is a 21-night South America cruise aboard Nieuw Amsterdam, operated by Holland America Line. Departing San Diego, California on October 12, 2027 and arriving in San Antonio, Chile on November 2, 2027, the voyage visits 12 ports including Cabo San Lucas, Santa Cruz, Mexico, Puerto Quetzal. Fares start from $4,324 per person.

Length
21 nights
Departs
Oct 12, 2027
Returns
Nov 2, 2027
Ports of call
12
Days at sea
8

Voyage code I777C

Cabo San Lucas

21 nights · South America

from $4,324 pp

via CruiseDirect

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Why this route stands out

A closer look at the journey

Cabo San Lucas

Found at the tip of Baja California, Cabo San Lucas is where the desert meets the ocean. Although it has received a makeover of modern Americana in recent years, this place is still a world away from everywhere else in Mexico. A trip to Cabo (the San Lucas is optional) will not leave you disappointed. With swaying palm trees, turquoise seas and long ribbons of white sand, this is a resort that ticks every box: great food, great nightlight which equal great times – for some. Others may prefer to scratch the surface just a bit deeper and travel along the peninsula that is known for its dramatic scenery of desert terrain and rugged coastline marked by many unusual formations. The sweeping views of the bay are simply sensational. A quick turn inward takes you to San Jose del Cabo, Cabo San Lucas’ older and more grown up sister. Offering a very much calmer and much more authentic atmosphere, just half an hour along the coast leaves you in its desert terrain, and leaves a very different impression from the lively beachfront bars and cafes of San Lucas. Perhaps one of the most stunning ways to see Cabo though is from the water. With the Arco de Cabo San Lucas featuring highly on many must-see lists, a trip around the bay is a must. The braver among you might also like to indulge their inner adrenalin junkie and swim with whale sharks – a memorable and totally risk-free experience if there ever was one. End your day of sightseeing with a fabulous sunset, a (tequila) sunrise in hand, watching the fishermen come home from their adventures.

Puerto Quetzal

A voyage between fire and water, between majestic volcanoes and stunning lakes. There are so many colors, you can get lost in them, from the bright traditional clothes of the people to the church facades. Everything is a rainbow of life in Guatemala, starting from Puerto Quetzal, the largest port in the country found on the Pacific Ocean and one of the stops of your MSC World Cruise. In the heart of the Mayan culture in Central America, you will begin an adventure that will combine the beauty of an artistic heritage with natural splendors, the discovery of ancient civilizations and the ruins of a still alive and vivacious people, such as can be found at the impressive ruins of Tikal, the largest of the ancient Mayan cities. The Mayan culture survives in the clothes of the people, religious processions, markets and sawdust and petal carpets, a symbol of Guatemalan sacredness. All of this can be found surrounded by an unspoiled habitat, one of the highest volcanoes in the region and what is considered to be one of the most beautiful lakes in the world. Your MSC cruise will take you along the enchanting shores of Lake Atitlan, formed 84,000 years ago in the highlands of Guatemala. Surrounded by many villages, where the inhabitants still wear Mayan traditional dress, the Atitlan boasts immense crops of coffee, avocado groves and a wide variety of agricultural crops along its shores. From Puerto Quetzal, you can easily reach another stop on your holiday: Antigua, a beautiful colonial city located in the center of the country. Famous for its examples of well-preserved Hispano-American Baroque architecture, the city was declared a World Heritage Site by UNESCO in 1979. With MSC Cruises, you can experience the lifestyle of Guatemala and its ancient evocative traditions, changing it from a dream into reality.

Puntarenas, Costa Rica

The Pearl of the Pacific Ocean On a fine sandy peninsula, 8 km long and an average width of 400 meters, Puntarenas, the "Pearl of the Pacific" can be found. During your MSC World Cruise, you will have the opportunity to visit this city, formerly the largest port in the country and now a busy place full of life, characterized by beautiful beaches and lush nature. One of the best excursions during your holiday in this land will be the Rainforest Skywalk, a combination of suspension bridges and trails through the rain forest to get you acquainted with one of the most complex ecosystems in the world made up of numerous native plant and animal species that can be observed directly in their natural habitat. Puntarenas is also famous for another treasure: its coffee, known as "Grano de Oro". It is not only among the best and most appreciated across the planet, but it has played a key role in the development of Costa Rica, affecting social institutions, culture and politics in the country. Thanks to your MSC Cruise, you will have the chance to taste exceptional coffee in its land of origin, where its roots can be found in the late 1700s in this fertile land with a cool climate, and which even today is one of the main agricultural exports of the country . Our cruise ship will also lead you on the discovery of San José, the capital city which is 115 km from Puntarenas. It is a must-see for its natural beauty, museums, historical sites and its characteristic streets markets. On its streets, you will find a cosmopolitan culture but one that is at the same time very close to roots. Surrounded by mountains and full of rivers and streams, San José is the icing on the cake of your vacation with MSC Cruises.

Price tracking

Today’s fare, in context

Price history

Cheaper than 76%
30 days
Fare details

Fare details

Per person · taxes & fees included
Current fares
Verified 6 hours ago
Inside
$4,324
Oceanview
$4,594
Balcony
$5,814
Suite
$8,704
Tracked range
156 days
Price history by cabin type
CabinCurrentLowestHighest
Inside $4,324 $4,219 on Jul 4 $4,344 on Mar 31
Oceanview $4,594 $4,489 on Jul 4 $4,599 on Apr 11
Balcony $5,814 $5,709 on Jul 4 $6,069 on Apr 11
Suite $8,704 $8,344 on Mar 31 $8,704 on Aug 1
Cabin grades
34 total
Verandah StateroomBalcony · V
Verandah StateroomBalcony · VA
Verandah StateroomBalcony · VB
Verandah StateroomBalcony · VC
Verandah StateroomBalcony · VD
Verandah StateroomBalcony · VE
Verandah StateroomBalcony · VF
Verandah StateroomBalcony · VH
Verandah Spa StateroomBalcony · VQ
Large Interior StateroomInside · I
Interior Spa StateroomInside · IQ
Large/Standard Inside StateroomInside · J
Large/Standard Inside StateroomInside · K
Standard Interior StateroomInside · L
Standard Interior StateroomInside · M
Standard Interior StateroomInside · MM
Standard Interior StateroomInside · N
Large Ocean view StateroomOceanview · C
Large Ocean view Spa StateroomOceanview · CQ
Large Ocean view StateroomOceanview · D
Large Ocean view StateroomOceanview · DD
Large Ocean view StateroomOceanview · E
Large Ocean view StateroomOceanview · F
Large Ocean view Stateroom (Partial Sea View)Oceanview · G
Large Ocean view Stateroom (Fully Obstructed View)Oceanview · H
Large Ocean view Stateroom (Fully Obstructed View)Oceanview · HH
Pinnacle SuiteSuite · PS
Neptune SuiteSuite · SA
Neptune SuiteSuite · SB
Neptune SuiteSuite · SC
Neptune Spa SuiteSuite · SQ
Signature SuiteSuite · SS
Signature SuiteSuite · SY
Signature SuiteSuite · SZ

○ = last seen (sold out or delisted). · Verified 6 hours ago.

Lowest fares with no residency, age, or service requirement — verify eligibility at booking. How our pricing works

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $4,324

$205 / night

Fare rows

Standard Interior Stateroom

Cabin grade

Available

from $4,324

$205 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $4,384

$208 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $4,414

$210 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $4,444

$211 / night

per person · incl. taxes & fees

Large/Standard Inside Stateroom

Cabin grade

Available

from $4,474

$213 / night

per person · incl. taxes & fees

Large/Standard Inside Stateroom

Cabin grade

Available

from $4,504

$214 / night

per person · incl. taxes & fees

Oceanview

from $4,594

$218 / night

Fare rows

Large Ocean view Stateroom (Fully Obstructed View)

Cabin grade

Available

from $4,594

$218 / night

per person · incl. taxes & fees

Large Ocean view Stateroom (Fully Obstructed View)

Cabin grade

Available

from $4,684

$223 / night

per person · incl. taxes & fees

Large Ocean view Stateroom (Partial Sea View)

Cabin grade

Available

from $4,754

$226 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $4,854

$231 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $4,944

$235 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $5,014

$238 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $5,084

$242 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $5,154

$245 / night

per person · incl. taxes & fees

Balcony

from $5,814

$276 / night

Fare rows

Verandah Stateroom

Cabin grade

Available

from $5,814

$276 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $5,964

$284 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,114

$291 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,234

$296 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,354

$302 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,474

$308 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,594

$314 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,714

$319 / night

per person · incl. taxes & fees

Verandah Spa Stateroom

Cabin grade

Available

from $6,834

$325 / night

per person · incl. taxes & fees

Suite

from $8,704

$414 / night

Fare rows

Signature Suite

Cabin grade

Available

from $8,704

$414 / night

per person · incl. taxes & fees

Signature Suite

Cabin grade

Available

from $9,104

$433 / night

per person · incl. taxes & fees

Signature Suite

Cabin grade

Available

from $9,504

$452 / night

per person · incl. taxes & fees

Neptune Suite

Cabin grade

Available

from $11,004

$524 / night

per person · incl. taxes & fees

Neptune Suite

Cabin grade

Available

from $11,814

$562 / night

per person · incl. taxes & fees

Neptune Suite

Cabin grade

Available

from $12,624

$601 / night

per person · incl. taxes & fees

Prices verified Sep 1, 2026

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The journey

21 nights, in order

San Diego, California

Day 1 Oct 12, 2027

San Diego, California

Free from smog and jungle-like freeways, San Diego sits gracefully around a beautiful curving bay.

Explore San Diego, California

Day by day

The full itinerary

22 scheduled calls
Nieuw Amsterdam

Your ship

Nieuw Amsterdam

The second of Holland America’s Signature Class ships, Nieuw Amsterdam, celebrates historic New York City with an inspired design and art collection. While on board, rejuvenate in the tranquil Spa & Salon, play pickleball at sea, or enjoy a tantalizing meal at fine dining restaurants. When you’re in the mood for music, Billboard Onboard fills the room with chart-topping hits.

5★ 86,700 GT 2,106 Passengers Built 2010
Nieuw Amsterdam ship guide Search cruises on Nieuw Amsterdam

Deck plans

Deck plan for DECK 1 - MAIN DECK

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from $4,324 pp

via CruiseDirect

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