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12-night Caribbean cruise: Miami, Florida to Panama City on Seven Seas Prestige

The Miami to Panama City is a 12-night Caribbean cruise aboard Seven Seas Prestige, operated by Regent Seven Seas Cruises. Departing Miami, Florida on March 2, 2028 and arriving in Panama City on March 14, 2028, the voyage visits 9 ports including Key West, George Town, Cayman Islands, Falmouth,Jamaica. Fares start from $8,249 per person.

Length
12 nights
Departs
Mar 2, 2028
Returns
Mar 14, 2028
Ports of call
9
Days at sea
4

Voyage code PRT280302

Miami, Florida

12 nights · Caribbean

from $8,249 pp

via CruiseDirect

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Book direct with Regent Seven Seas Cruises we may earn a commission

Why this route stands out

A closer look at the journey

Miami, Florida

Miami is called the gateway to the Americas, and it’s indeed a very glamourous global city to explore at the start or end of an MSC Caribbean and Antilles cruise. Home to many cultures, the city of Miami sizzles with flavours from the Americas, beginning with Cuba and the Little Havana neighbourhood - one of the most historically significant places, while Wynwood is famous for its wall art and Puerto Rican history. Across Biscayne Bay lies the city of Miami Beach, home to the world-famous South Beach. An MSC-arranged guided private tour opens up a world of possibilities for you: enjoy the beach, take in the city’s Art Deco architecture and enjoy a drink on legendary Ocean Drive, where you can people watch, and perhaps spot a celebrity. If time permits, take a stroll on artsy Lincoln Road packed with street side cafes and shops. Facing the MSC Cruises port in downtown Miami is Bayside Marketplace - a lively commercial centre that is a staging area for boat tours of Miami. Seeing the city from the water, with its impressive skyline and waterfront mansions, is an experience in itself. The downtown area also boasts the dazzling Performing Arts Centre, the Museum of Science, the Pérez Art Museum Miami (known as the PAMM), scenic Bayfront Park and the arena where the 3-time NBA champion Miami Heat basketball team plays. Miami is renowned for its shopping. Hop on a tour to see the major city sights followed by retail therapy at one of Miami's largest and newest shopping malls: Dolphin Mall. With more than 240 retail outlets, you’re bound to need a bit of room in your luggage for your purchases. Luckily, there are several luggage stores at the mall to fill that need. Head west past the city into untamed wilderness on an MSC excursion into the Everglades. At this national park where water is the central feature, unlike any other in North America, nature enthusiasts can hop on an airboat tour through the swampland and waterways to spot alligators and a variety of birds.

Key West

If viewed from afar, Key West seems to float amid a large expanse of sky and sea. An MSC Cruise will take you right to the southernmost point of the United States, in the Sunshine State, a land of sun-seekers and wild beaches. About 150 km from Cuba, an MSC cruise in the Caribbean and the Antilles is an opportunity to admire the crystal clear waters surrounding Key West, a strip of land just a few kilometers from Miami. The Spaniards nicknamed it "Island of Bones", because here the indigenous people buried their deceased loved ones. Connected to the mainland by bridges, Key West is literally a paradise that offers a breathtaking panorama and stages an ancient culture and history. Enjoy the sunset at Mallory Square and get lost in Duval street, one of the liveliest streets of the city, with shops, clubs and restaurants, and you won't ever want to leave. It is no coincidence that the likes of Harry S. Truman, Tennessee Williams and Ernest Hemingway decided to reside here. Don’t miss the chance to visit the residence of Hemingway himself: An MSC excursion will take you inside the villa, now a museum, where the writer lived for about ten years. A dive into his life: the paintings, the typewriter, the kitchen and every corner that the writer shared with his second wife Pauline Pfeiffer. During his stay in Key West, Hemingway wrote his novel The Old Man and the Sea, winner of a Pulitzer Prize and the Nobel Prize. When in Key West, a visit to the sea is a must. With an MSC excursion it is possible to see its depths, from the comfort of a glass-bottomed boat, built to admire the different varieties of colorful fish that populate the Atlantic Ocean. For adventure lovers, the ideal is an MSC kayak excursion. A unique experience through coral reefs and mangroves: experienced professionals will guide you in search of fish, birds, turtles and, if you're lucky, even barracudas and manta rays.

George Town, Cayman Islands

Christopher Columbus called the Cayman Islands, with their tranquil blue waters, "Las Tortugas" for its abundance of turtles. Located between Cuba and Jamaica, the Cayman Islands are comprised of three Caribbean islands: Grand Cayman, Little Cayman and Cayman Brac. Beautiful landscapes, bountiful wildlife and colourful streets embody this British Overseas Territory, with George Town, its capital, located on Grand Cayman, the largest and most populous island. When you arrive in George Town on an MSC Caribbean and Antilles cruise, you’ll discover that wildlife conservation is at the core of Grand Cayman’s offerings. For the chance of a lifetime to swim, feed and interact with stingrays, book an MSC excursion to Stingray City, where you’ll get an up-close experience with Cayman’s most graceful marine creatures. On yet another MSC excursion to the Cayman Turtle Centre, encounter the green turtles that return each and every year to lay their eggs on one of the beaches, visit the turtle hatchery, snorkel alongside yearlings in the Turtle Lagoon and meet the island’s endangered blue iguanas. For a special experience, ride horses bareback into the Caribbean Sea at Barker’s National Park on an exclusive Martha Stewart excursion curated just for MSC Cruises, followed by lunch at Vivo café, a spot beloved for its mostly vegan cuisine, with organic ingredients sourced straight from local farms. To learn about Cayman’s past and culture, explore Cayman Heritage House and visit the sumptuous Government House, the governor's residence built in 1964 located in front of Seven Mile Beach, one of the most prestigious beaches of Grand Cayman, in the heart of West Bay. Shopaholics will also delight in this destination. The Cayman Islands are entirely duty free. You just have to choose what catches your fancy among the myriad of watches, liqueurs, jewellery and porcelain on offer.

Price tracking

Today’s fare, in context

Price history

Cheaper than 41%
90 days
Fare details

Fare details

Per person · taxes & fees included
Current fares
Verified 7 hours ago
Suite
$8,249
Tracked range
163 days
Price history by cabin type
CabinCurrentLowestHighest
Suite $8,249 $7,899 on Jun 12 $8,799 on Mar 26
Cabin grades
20 total
Penthouse SuiteSuite · A
Penthouse SuiteSuite · B
Penthouse SuiteSuite · C
Concierge SuiteSuite · D
Concierge SuiteSuite · E
Serenity SuiteSuite · F1
Serenity SuiteSuite · F2
Deluxe Veranda SuiteSuite · G
Grand SuiteSuite · GS
Deluxe Veranda SuiteSuite · H
Horizon Penthouse SuiteSuite · HP
SuiteSuite · I
Grand Loft SuiteSuite · LS
Prestige SuiteSuite · PS
Skyview Regent SuiteSuite · RS
Signature SuiteSuite · SG
Skyview Aura SuiteSuite · SKA
Skyview Luna SuiteSuite · SKB
Skyview Sola SuiteSuite · SKC
Seven Seas SuiteSuite · SS

○ = last seen (sold out or delisted). · Verified 7 hours ago.

Lowest fares with no residency, age, or service requirement — verify eligibility at booking. How our pricing works

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

Not available

Oceanview

Not available

Balcony

Not available

Suite

from $8,249

$687 / night

Fare rows

Deluxe Veranda Suite

Cabin grade

Available

from $8,249

$687 / night

per person · incl. taxes & fees

Deluxe Veranda Suite

Cabin grade

Available

from $8,449

$704 / night

per person · incl. taxes & fees

Serenity Suite

Cabin grade

Available

from $8,649

$720 / night

per person · incl. taxes & fees

Serenity Suite

Cabin grade

Available

from $8,849

$737 / night

per person · incl. taxes & fees

Concierge Suite

Cabin grade

Available

from $9,019

$751 / night

per person · incl. taxes & fees

Concierge Suite

Cabin grade

Available

from $9,319

$776 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $10,269

$855 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $10,569

$880 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $10,869

$905 / night

per person · incl. taxes & fees

Deluxe Veranda Suite

Cabin grade

Available

from $11,249

$937 / night

per person · incl. taxes & fees

Deluxe Veranda Suite

Cabin grade

Available

from $11,449

$954 / night

per person · incl. taxes & fees

Horizon Penthouse Suite

Cabin grade

Available

from $11,569

$964 / night

per person · incl. taxes & fees

Serenity Suite

Cabin grade

Available

from $11,649

$970 / night

per person · incl. taxes & fees

Serenity Suite

Cabin grade

Available

from $11,849

$987 / night

per person · incl. taxes & fees

Concierge Suite

Cabin grade

Available

from $12,249

$1,020 / night

per person · incl. taxes & fees

Concierge Suite

Cabin grade

Available

from $12,549

$1,045 / night

per person · incl. taxes & fees

Seven Seas Suite

Cabin grade

Available

from $12,919

$1,076 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $13,499

$1,124 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $13,799

$1,149 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $14,099

$1,174 / night

per person · incl. taxes & fees

Prestige Suite

Cabin grade

Available

from $14,769

$1,230 / night

per person · incl. taxes & fees

Horizon Penthouse Suite

Cabin grade

Available

from $14,799

$1,233 / night

per person · incl. taxes & fees

Seven Seas Suite

Cabin grade

Available

from $16,149

$1,345 / night

per person · incl. taxes & fees

Prestige Suite

Cabin grade

Available

from $17,999

$1,499 / night

per person · incl. taxes & fees

Grand Suite

Cabin grade

Available

from $18,969

$1,580 / night

per person · incl. taxes & fees

Grand Loft Suite

Cabin grade

Available

from $19,019

$1,584 / night

per person · incl. taxes & fees

Grand Suite

Cabin grade

Available

from $22,199

$1,849 / night

per person · incl. taxes & fees

Grand Loft Suite

Cabin grade

Available

from $22,249

$1,854 / night

per person · incl. taxes & fees

Signature Suite

Cabin grade

Available

from $31,419

$2,618 / night

per person · incl. taxes & fees

Skyview Sola Suite

Cabin grade

Available

from $32,169

$2,680 / night

per person · incl. taxes & fees

Signature Suite

Cabin grade

Available

from $34,649

$2,887 / night

per person · incl. taxes & fees

Skyview Sola Suite

Cabin grade

Available

from $35,399

$2,949 / night

per person · incl. taxes & fees

Skyview Aura Suite

Cabin grade

Available

from $37,969

$3,164 / night

per person · incl. taxes & fees

Skyview Aura Suite

Cabin grade

Available

from $41,199

$3,433 / night

per person · incl. taxes & fees

Skyview Regent Suite

Cabin grade

Available

from $149,769

$12,480 / night

per person · incl. taxes & fees

Skyview Regent Suite

Cabin grade

Available

from $152,999

$12,749 / night

per person · incl. taxes & fees

Prices verified Sep 4, 2026

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The journey

12 nights, in order

Miami, Florida

Day 1 Mar 2, 2028

Miami, Florida

Miami is called the gateway to the Americas, and it’s indeed a very glamourous global city to explore at the start or end of an MSC Caribbean and Antilles cruise.

Explore Miami, Florida

Day by day

The full itinerary

13 scheduled calls
Seven Seas Prestige

Your ship

Seven Seas Prestige

Seven Seas Prestige will be the first of two Prestige-Class ships, the second of which will be launched in 2029. The new ship class will introduce brand new accommodation categories, including a reimagination of the palatial Regent Suite, plus new dining experiences, all of which will be revealed at a later date. These new features will further enhance The Most Inclusive Luxury Experience® that Regent is known for with inclusions such as flights and transfers, gourmet cuisine in a range of specialty restaurants and al-fresco dining venues, fine wines and spirits, entertainment, unlimited internet access, free valet laundry, gratuities, one-night, pre-cruise hotel packages for guests staying in Concierge-level suites and higher and more.

6★ 77,000 GT 850 Passengers
Seven Seas Prestige ship guide Search cruises on Seven Seas Prestige

Deck plans

Deck plan for Deck 4

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More ways to take this journey

Fly-cruise options

Fly-cruise package options
Airport Price pp Included
ABQ $154,269.00 Extra
ALB $154,219.00 Extra
ATL $154,189.00 Extra
AUS $154,239.00 Extra
AVL $154,239.00 Extra
BDL $154,219.00 Extra
BFL $154,259.00 Extra
BHM $154,239.00 Extra
BIL $154,269.00 Extra
BNA $154,239.00 Extra
BOI $154,269.00 Extra
BOS $154,169.00 Extra
BUF $154,219.00 Extra
BWI $154,159.00 Extra
CHA $154,239.00 Extra
CHS $154,239.00 Extra
CID $154,239.00 Extra
CLE $154,239.00 Extra
CLT $154,249.00 Extra
CMH $154,239.00 Extra
COS $154,269.00 Extra
CVG $154,239.00 Extra
DCA $154,159.00 Extra
DEN $154,239.00 Extra
DFW $154,229.00 Extra
DSM $154,239.00 Extra
DTW $154,169.00 Extra
ELP $154,269.00 Extra
EUG $154,259.00 Extra
EWR $154,139.00 Extra
FAR $154,239.00 Extra
FAT $154,259.00 Extra
FLL $153,789.00 Extra
FSD $154,239.00 Extra
GEG $154,259.00 Extra
GRR $154,239.00 Extra
GSO $154,259.00 Extra
GSP $154,239.00 Extra
GTF $154,269.00 Extra
HNL $154,259.00 Extra
HSV $154,239.00 Extra
IAD $154,159.00 Extra
IAH $154,219.00 Extra
ICT $154,239.00 Extra
ILM $154,239.00 Extra
IND $154,239.00 Extra
JAN $154,239.00 Extra
JAX $154,249.00 Extra
JFK $154,139.00 Extra
LAS $154,269.00 Extra
LAX $154,259.00 Extra
LBB $154,239.00 Extra
LEX $154,239.00 Extra
LGA $154,139.00 Extra
LIT $154,239.00 Extra
MAF $154,239.00 Extra
MCI $154,239.00 Extra
MCO $154,139.00 Extra
MDW $154,189.00 Extra
MEM $154,239.00 Extra
MIA $153,789.00 Extra
MKE $154,239.00 Extra
MOB $154,239.00 Extra
MSN $154,239.00 Extra
MSP $154,249.00 Extra
MSY $154,239.00 Extra
MYR $154,239.00 Extra
OKC $154,239.00 Extra
OMA $154,239.00 Extra
ORD $154,189.00 Extra
ORF $154,239.00 Extra
PBI $153,789.00 Extra
PDX $154,259.00 Extra
PHL $154,249.00 Extra
PHX $154,259.00 Extra
PIA $154,239.00 Extra
PIT $154,239.00 Extra
PSP $154,259.00 Extra
PVD $154,219.00 Extra
PWM $154,219.00 Extra
RDU $154,239.00 Extra
RIC $154,239.00 Extra
RNO $154,269.00 Extra
ROC $154,219.00 Extra
RSW $153,789.00 Extra
SAN $154,249.00 Extra
SAT $154,239.00 Extra
SAV $154,309.00 Extra
SBA $154,259.00 Extra
SDF $154,239.00 Extra
SEA $154,219.00 Extra
SFO $154,219.00 Extra
SGF $154,239.00 Extra
SHV $154,239.00 Extra
SLC $154,269.00 Extra
SMF $154,259.00 Extra
SNA $154,259.00 Extra
STL $154,239.00 Extra
SYR $154,219.00 Extra
TPA $154,219.00 Extra
TUL $154,239.00 Extra
TUS $154,269.00 Extra
TYS $154,239.00 Extra
XNA $154,239.00 Extra
YEG $154,269.00 Extra
YOW $154,219.00 Extra
YUL $154,189.00 Extra
YVR $154,269.00 Extra
YYC $154,269.00 Extra
YYJ $154,259.00 Extra
YYZ $154,169.00 Extra

from $8,249 pp

via CruiseDirect

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