Los Angeles, CA to Panama City

Itinerary

Los Angeles, CA photo — Day 1 Feb 10, 2027 Los Angeles, CA Departs 17:00 Los Angeles is a huge city with a thousand facets and attractions, one of the most stimulating urban centers that can be visited ever. Your MSC World Cruise will take you on the discovery of a place that has no equal, with its golden Pacific beaches, theme parks from the film world and walks down Sunset Boulevard with the Walk of Fame and its various museums. Los Angeles is perfect for those who enjoy shopping, entertainment and relaxation for a truly unforgettable vacation. What will the main stops on your MSC Cruises excursion be? No doubt a visit to Beverly Hills, the exclusive center of fashion and beauty where you can admire a multitude of homes in full California style. This residential area is famous for its proximity to Hollywood and for being home to many movie stars, as well as for hosting some of the most beautiful restaurants, shops and hotels in the world. And how could you not visit impressive Malibu, the seaside town in the west of the coast of Los Angeles. The beaches here are the best for swimming and sunbathing, thanks to the beautiful landscape that accompanies them, the jagged mountains of the Santa Monica Mountains National Recreation Area. Not far from Malibu is Santa Monica, another glittering attraction known for its famous Luna Park that was built on the pier in 1909. This bustling city is also popular for its climate, the beauty of the coast, the efficiency of its services, its clubs, shops and lively pedestrian streets that are full of street artists who have made Santa Monica one of the main destinations of Los Angeles. With MSC Cruises, you will have the chance to see one of the most beautiful cities in the world with your own eyes. Los Angeles, CA port guide Search cruises visiting Los Angeles, CA

Day 4 Feb 13, 2027 Cabo San Lucas 08:00 – 18:00 10.0 hrs ashore Found at the tip of Baja California, Cabo San Lucas is where the desert meets the ocean. Although it has received a makeover of modern Americana in recent years, this place is still a world away from everywhere else in Mexico. A trip to Cabo (the San Lucas is optional) will not leave you disappointed. With swaying palm trees, turquoise seas and long ribbons of white sand, this is a resort that ticks every box: great food, great nightlight which equal great times – for some. Others may prefer to scratch the surface just a bit deeper and travel along the peninsula that is known for its dramatic scenery of desert terrain and rugged coastline marked by many unusual formations. The sweeping views of the bay are simply sensational. A quick turn inward takes you to San Jose del Cabo, Cabo San Lucas’ older and more grown up sister. Offering a very much calmer and much more authentic atmosphere, just half an hour along the coast leaves you in its desert terrain, and leaves a very different impression from the lively beachfront bars and cafes of San Lucas. Perhaps one of the most stunning ways to see Cabo though is from the water. With the Arco de Cabo San Lucas featuring highly on many must-see lists, a trip around the bay is a must. The braver among you might also like to indulge their inner adrenalin junkie and swim with whale sharks – a memorable and totally risk-free experience if there ever was one. End your day of sightseeing with a fabulous sunset, a (tequila) sunrise in hand, watching the fishermen come home from their adventures. Cabo San Lucas port guide Search cruises visiting Cabo San Lucas

Cabo San Lucas photo — Day 4 Feb 13, 2027 Cabo San Lucas 08:00 – 18:00 10.0 hrs ashore Found at the tip of Baja California, Cabo San Lucas is where the desert meets the ocean. Although it has received a makeover of modern Americana in recent years, this place is still a world away from everywhere else in Mexico. A trip to Cabo (the San Lucas is optional) will not leave you disappointed. With swaying palm trees, turquoise seas and long ribbons of white sand, this is a resort that ticks every box: great food, great nightlight which equal great times – for some. Others may prefer to scratch the surface just a bit deeper and travel along the peninsula that is known for its dramatic scenery of desert terrain and rugged coastline marked by many unusual formations. The sweeping views of the bay are simply sensational. A quick turn inward takes you to San Jose del Cabo, Cabo San Lucas’ older and more grown up sister. Offering a very much calmer and much more authentic atmosphere, just half an hour along the coast leaves you in its desert terrain, and leaves a very different impression from the lively beachfront bars and cafes of San Lucas. Perhaps one of the most stunning ways to see Cabo though is from the water. With the Arco de Cabo San Lucas featuring highly on many must-see lists, a trip around the bay is a must. The braver among you might also like to indulge their inner adrenalin junkie and swim with whale sharks – a memorable and totally risk-free experience if there ever was one. End your day of sightseeing with a fabulous sunset, a (tequila) sunrise in hand, watching the fishermen come home from their adventures. Cabo San Lucas port guide Search cruises visiting Cabo San Lucas

Day 5 Feb 14, 2027 Mazatlan, Mexico 07:00 – 18:00 11.0 hrs ashore Book a Mexico Cruise with Holland America Line and sail to the port city of Mazatlán, where the best of traditional Mexican architecture, food and culture is found alongside contemporary conveniences, amenities and attractions. There's a reason why Americans and Canadians flock here, particularly in winter: It's a warm and welcoming place with plenty to keep visitors entertained for a vacation getaway. Cruise to Mazatlán and explore an array of activities on a Mazatlán shore excursion. There really is something for everyone here, from golfing, fishing and zip lining to sampling agave-based spirits on a distillery tour or learning more about local history at the archaeological museum. There are plenty of cultural opportunities, too, from performances at the Teatro Ángela Peralta to witnessing death-defying cliff dives that will make you hold your breath until divers resurface from the churning surf. On a cruise to Mazatlán don’t forgot to taste some local cuisine. Mazatlán keeps visitors' appetites sated; thanks to the city's coastal location, seafood is freshly caught, and shrimp-based dishes are a particular specialty in local restaurants. And if you can't head home without a souvenir, there's locally made liquor or handmade crafts that can fit neatly into your luggage.

Day 9 Feb 18, 2027 Puerto Quetzal 08:00 – 18:00 10.0 hrs ashore A voyage between fire and water, between majestic volcanoes and stunning lakes. There are so many colors, you can get lost in them, from the bright traditional clothes of the people to the church facades. Everything is a rainbow of life in Guatemala, starting from Puerto Quetzal, the largest port in the country found on the Pacific Ocean and one of the stops of your MSC World Cruise. In the heart of the Mayan culture in Central America, you will begin an adventure that will combine the beauty of an artistic heritage with natural splendors, the discovery of ancient civilizations and the ruins of a still alive and vivacious people, such as can be found at the impressive ruins of Tikal, the largest of the ancient Mayan cities. The Mayan culture survives in the clothes of the people, religious processions, markets and sawdust and petal carpets, a symbol of Guatemalan sacredness. All of this can be found surrounded by an unspoiled habitat, one of the highest volcanoes in the region and what is considered to be one of the most beautiful lakes in the world. Your MSC cruise will take you along the enchanting shores of Lake Atitlan, formed 84,000 years ago in the highlands of Guatemala. Surrounded by many villages, where the inhabitants still wear Mayan traditional dress, the Atitlan boasts immense crops of coffee, avocado groves and a wide variety of agricultural crops along its shores. From Puerto Quetzal, you can easily reach another stop on your holiday: Antigua, a beautiful colonial city located in the center of the country. Famous for its examples of well-preserved Hispano-American Baroque architecture, the city was declared a World Heritage Site by UNESCO in 1979. With MSC Cruises, you can experience the lifestyle of Guatemala and its ancient evocative traditions, changing it from a dream into reality. Puerto Quetzal port guide Search cruises visiting Puerto Quetzal

Puerto Quetzal photo — Day 9 Feb 18, 2027 Puerto Quetzal 08:00 – 18:00 10.0 hrs ashore A voyage between fire and water, between majestic volcanoes and stunning lakes. There are so many colors, you can get lost in them, from the bright traditional clothes of the people to the church facades. Everything is a rainbow of life in Guatemala, starting from Puerto Quetzal, the largest port in the country found on the Pacific Ocean and one of the stops of your MSC World Cruise. In the heart of the Mayan culture in Central America, you will begin an adventure that will combine the beauty of an artistic heritage with natural splendors, the discovery of ancient civilizations and the ruins of a still alive and vivacious people, such as can be found at the impressive ruins of Tikal, the largest of the ancient Mayan cities. The Mayan culture survives in the clothes of the people, religious processions, markets and sawdust and petal carpets, a symbol of Guatemalan sacredness. All of this can be found surrounded by an unspoiled habitat, one of the highest volcanoes in the region and what is considered to be one of the most beautiful lakes in the world. Your MSC cruise will take you along the enchanting shores of Lake Atitlan, formed 84,000 years ago in the highlands of Guatemala. Surrounded by many villages, where the inhabitants still wear Mayan traditional dress, the Atitlan boasts immense crops of coffee, avocado groves and a wide variety of agricultural crops along its shores. From Puerto Quetzal, you can easily reach another stop on your holiday: Antigua, a beautiful colonial city located in the center of the country. Famous for its examples of well-preserved Hispano-American Baroque architecture, the city was declared a World Heritage Site by UNESCO in 1979. With MSC Cruises, you can experience the lifestyle of Guatemala and its ancient evocative traditions, changing it from a dream into reality. Puerto Quetzal port guide Search cruises visiting Puerto Quetzal

Day 11 Feb 20, 2027 Puntarenas, Costa Rica 08:00 – 18:00 10.0 hrs ashore The Pearl of the Pacific Ocean On a fine sandy peninsula, 8 km long and an average width of 400 meters, Puntarenas, the "Pearl of the Pacific" can be found. During your MSC World Cruise, you will have the opportunity to visit this city, formerly the largest port in the country and now a busy place full of life, characterized by beautiful beaches and lush nature. One of the best excursions during your holiday in this land will be the Rainforest Skywalk, a combination of suspension bridges and trails through the rain forest to get you acquainted with one of the most complex ecosystems in the world made up of numerous native plant and animal species that can be observed directly in their natural habitat. Puntarenas is also famous for another treasure: its coffee, known as "Grano de Oro". It is not only among the best and most appreciated across the planet, but it has played a key role in the development of Costa Rica, affecting social institutions, culture and politics in the country. Thanks to your MSC Cruise, you will have the chance to taste exceptional coffee in its land of origin, where its roots can be found in the late 1700s in this fertile land with a cool climate, and which even today is one of the main agricultural exports of the country . Our cruise ship will also lead you on the discovery of San José, the capital city which is 115 km from Puntarenas. It is a must-see for its natural beauty, museums, historical sites and its characteristic streets markets. On its streets, you will find a cosmopolitan culture but one that is at the same time very close to roots. Surrounded by mountains and full of rivers and streams, San José is the icing on the cake of your vacation with MSC Cruises. Puntarenas, Costa Rica port guide Search cruises visiting Puntarenas, Costa Rica

Puntarenas, Costa Rica photo — Day 11 Feb 20, 2027 Puntarenas, Costa Rica 08:00 – 18:00 10.0 hrs ashore The Pearl of the Pacific Ocean On a fine sandy peninsula, 8 km long and an average width of 400 meters, Puntarenas, the "Pearl of the Pacific" can be found. During your MSC World Cruise, you will have the opportunity to visit this city, formerly the largest port in the country and now a busy place full of life, characterized by beautiful beaches and lush nature. One of the best excursions during your holiday in this land will be the Rainforest Skywalk, a combination of suspension bridges and trails through the rain forest to get you acquainted with one of the most complex ecosystems in the world made up of numerous native plant and animal species that can be observed directly in their natural habitat. Puntarenas is also famous for another treasure: its coffee, known as "Grano de Oro". It is not only among the best and most appreciated across the planet, but it has played a key role in the development of Costa Rica, affecting social institutions, culture and politics in the country. Thanks to your MSC Cruise, you will have the chance to taste exceptional coffee in its land of origin, where its roots can be found in the late 1700s in this fertile land with a cool climate, and which even today is one of the main agricultural exports of the country . Our cruise ship will also lead you on the discovery of San José, the capital city which is 115 km from Puntarenas. It is a must-see for its natural beauty, museums, historical sites and its characteristic streets markets. On its streets, you will find a cosmopolitan culture but one that is at the same time very close to roots. Surrounded by mountains and full of rivers and streams, San José is the icing on the cake of your vacation with MSC Cruises. Puntarenas, Costa Rica port guide Search cruises visiting Puntarenas, Costa Rica

Day 13 Feb 22, 2027 Panama City Arrives 07:00 You probably can’t think of Panama City without conjuring images of the Panama Canal. But nearly 400 years before the Panama Canal opened its locks, Panama City was making its mark. From the vestiges of the original settlement to the modern skyscrapers, experience the history and culture of one of the Pacific Coast’s oldest continuously inhabited European settlements. After exploring the bustling local markets in search of fresh fish or artisan handicrafts, admire the restored Spanish Colonial architecture in Casco Viejo. Or you can head to the Miraflores Locks and watch one of the modern world’s most heroic feats of engineering in action. Panama City port guide Search cruises visiting Panama City

Panama City photo — Day 13 Feb 22, 2027 Panama City Arrives 07:00 You probably can’t think of Panama City without conjuring images of the Panama Canal. But nearly 400 years before the Panama Canal opened its locks, Panama City was making its mark. From the vestiges of the original settlement to the modern skyscrapers, experience the history and culture of one of the Pacific Coast’s oldest continuously inhabited European settlements. After exploring the bustling local markets in search of fresh fish or artisan handicrafts, admire the restored Spanish Colonial architecture in Casco Viejo. Or you can head to the Miraflores Locks and watch one of the modern world’s most heroic feats of engineering in action. Panama City port guide Search cruises visiting Panama City

Pricing

Lowest fare we've tracked over the observed 91-day span: $7,549 · range $7,549–$8,849

Lower than 93% of peers This longer-duration sailing's from-price per night is lower than 93% of comparable sailings.

same cruise line and duration · from-price per night · as of Jun 23, 2026 · Broader cohort: same cruise line and duration, compared by from-price per night.

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

Not available

Oceanview

Not available

Balcony

Not available

Suite

from $7,549

$629 / night

Fare rows

Deluxe Veranda Suite

Cabin grade

Available

from $7,549

$629 / night

per person · incl. taxes

Serenity Suite

Cabin grade

Available

from $7,899

$658 / night

per person · incl. taxes

Serenity Suite

Cabin grade

Available

from $7,949

$662 / night

per person · incl. taxes

Concierge Suite

Cabin grade

Available

from $8,249

$687 / night

per person · incl. taxes

Concierge Suite

Cabin grade

Available

from $8,499

$708 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $9,699

$808 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $10,049

$837 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $10,349

$862 / night

per person · incl. taxes

Deluxe Veranda Suite

Cabin grade

Available

from $10,549

$879 / night

per person · incl. taxes

Serenity Suite

Cabin grade

Available

from $10,899

$908 / night

per person · incl. taxes

Serenity Suite

Cabin grade

Available

from $10,949

$912 / night

per person · incl. taxes

Concierge Suite

Cabin grade

Available

from $11,399

$949 / night

per person · incl. taxes

Horizon Penthouse Suite

Cabin grade

Available

from $11,599

$966 / night

per person · incl. taxes

Concierge Suite

Cabin grade

Available

from $11,649

$970 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $12,849

$1,070 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $13,199

$1,099 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $13,499

$1,124 / night

per person · incl. taxes

Horizon Penthouse Suite

Cabin grade

Available

from $14,749

$1,229 / night

per person · incl. taxes

Grand Loft Suite

Cabin grade

Available

from $21,749

$1,812 / night

per person · incl. taxes

Grand Loft Suite

Cabin grade

Available

from $24,899

$2,074 / night

per person · incl. taxes

Prices verified Jun 23, 2026

Prices come from third-party data feeds via Regent Seven Seas Cruises and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

Show all 20 cabin grades

Name	Supplier code	Type
Penthouse Suite	A	Suite
Penthouse Suite	B	Suite
Penthouse Suite	C	Suite
Concierge Suite	D	Suite
Concierge Suite	E	Suite
Serenity Suite	F1	Suite
Serenity Suite	F2	Suite
Deluxe Veranda Suite	G	Suite
Grand Suite	GS	Suite
Deluxe Veranda Suite	H	Suite
Horizon Penthouse Suite	HP	Suite
Suite	I	Suite
Grand Loft Suite	LS	Suite
Prestige Suite	PS	Suite
Skyview Regent Suite	RS	Suite
Signature Suite	SG	Suite
Skyview Aura Suite	SKA	Suite
Skyview Luna Suite	SKB	Suite
Skyview Sola Suite	SKC	Suite
Seven Seas Suite	SS	Suite

Ship

Your ship Seven Seas Prestige 6★ **77,000** GT **850** guests Seven Seas Prestige will be the first of two Prestige-Class ships, the second of which will be launched in 2029. The new ship class will introduce brand new accommodation categories, including a reimagination of the palatial Regent Suite, plus new dining experiences, all of which will be revealed at a later date. These new features will further enhance The Most Inclusive Luxury Experience® that Regent is known for with inclusions such as flights and transfers, gourmet cuisine in a range of specialty restaurants and al-fresco dining venues, fine wines and spirits, entertainment, unlimited internet access, free valet laundry, gratuities, one-night, pre-cruise hotel packages for guests staying in Concierge-level suites and higher and more. Seven Seas Prestige ship guide Search cruises on Seven Seas Prestige

Fly-cruise options

Airport	Price pp	Included
ABQ	$24,439.00	Extra
ALB	$24,439.00	Extra
ATL	$24,439.00	Extra
AUS	$24,439.00	Extra
AVL	$24,439.00	Extra
BDL	$24,439.00	Extra
BFL	$24,439.00	Extra
BHM	$24,439.00	Extra
BIL	$24,439.00	Extra
BNA	$24,439.00	Extra
BOI	$24,439.00	Extra
BOS	$24,439.00	Extra
BUF	$24,439.00	Extra
BWI	$24,439.00	Extra
CHA	$24,439.00	Extra
CHS	$24,439.00	Extra
CID	$24,439.00	Extra
CLE	$24,439.00	Extra
CLT	$24,439.00	Extra
CMH	$24,439.00	Extra
COS	$24,439.00	Extra
CVG	$24,439.00	Extra
DCA	$24,439.00	Extra
DEN	$24,439.00	Extra
DFW	$24,439.00	Extra
DSM	$24,439.00	Extra
DTW	$24,439.00	Extra
ELP	$24,439.00	Extra
EUG	$24,439.00	Extra
EWR	$24,439.00	Extra
FAR	$24,439.00	Extra
FAT	$24,439.00	Extra
FLL	$24,439.00	Extra
FSD	$24,439.00	Extra
GEG	$24,439.00	Extra
GRR	$24,439.00	Extra
GSO	$24,439.00	Extra
GSP	$24,439.00	Extra
GTF	$24,439.00	Extra
HNL	$24,439.00	Extra
HSV	$24,439.00	Extra
IAD	$24,439.00	Extra
IAH	$24,439.00	Extra
ICT	$24,439.00	Extra
ILM	$24,439.00	Extra
IND	$24,439.00	Extra
JAN	$24,439.00	Extra
JAX	$24,439.00	Extra
JFK	$24,439.00	Extra
LAS	$24,439.00	Extra
LBB	$24,439.00	Extra
LEX	$24,439.00	Extra
LGA	$24,439.00	Extra
LIT	$24,439.00	Extra
MAF	$24,439.00	Extra
MCI	$24,439.00	Extra
MCO	$24,439.00	Extra
MDW	$24,439.00	Extra
MEM	$24,439.00	Extra
MIA	$24,439.00	Extra
MKE	$24,439.00	Extra
MOB	$24,439.00	Extra
MSN	$24,439.00	Extra
MSP	$24,439.00	Extra
MSY	$24,439.00	Extra
MYR	$24,439.00	Extra
OKC	$24,439.00	Extra
OMA	$24,439.00	Extra
ORD	$24,439.00	Extra
ORF	$24,439.00	Extra
PBI	$24,439.00	Extra
PDX	$24,439.00	Extra
PHL	$24,439.00	Extra
PHX	$24,439.00	Extra
PIA	$24,439.00	Extra
PIT	$24,439.00	Extra
PSP	$24,439.00	Extra
PVD	$24,439.00	Extra
PWM	$24,439.00	Extra
RDU	$24,439.00	Extra
RIC	$24,439.00	Extra
RNO	$24,439.00	Extra
ROC	$24,439.00	Extra
RSW	$24,439.00	Extra
SAN	$24,439.00	Extra
SAT	$24,439.00	Extra
SAV	$24,439.00	Extra
SBA	$24,439.00	Extra
SDF	$24,439.00	Extra
SEA	$24,439.00	Extra
SFO	$24,439.00	Extra
SGF	$24,439.00	Extra
SHV	$24,439.00	Extra
SLC	$24,439.00	Extra
SMF	$24,439.00	Extra
STL	$24,439.00	Extra
SYR	$24,439.00	Extra
TPA	$24,439.00	Extra
TUL	$24,439.00	Extra
TUS	$24,439.00	Extra
TYS	$24,439.00	Extra
XNA	$24,439.00	Extra
YEG	$24,439.00	Extra
YOW	$24,439.00	Extra
YUL	$24,439.00	Extra
YVR	$24,439.00	Extra
YYC	$24,439.00	Extra
YYJ	$24,439.00	Extra
YYZ	$24,439.00	Extra

Los Angeles, CA to Panama City

Itinerary

Pricing

Current prices

Inside

Oceanview

Balcony

Suite

Price history

Ship

Similar cruises

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Fly-cruise options