Santiago, Chile — Photo by Thomas Griggs on Unsplash

Santiago, Chile cruise port guide

Santiago, Chile’s capital and largest city, sits in a valley surrounded by the snow-capped Andes and the Chilean Coast Range. Plaza de Armas, the grand heart of the city’s old colonial core, is home to 2 neoclassical landmarks: the 1808 Palacio de la Real Audiencia, housing the National History Museum, and the 18th-century Metropolitan Cathedral. La Chascona is the home-turned-museum of poet Pablo Neruda.

About Santiago, Chile

Santiago is Chile's capital and largest city, a sophisticated metropolis set against the backdrop of the snow-capped Andes. Cruise ships call at nearby Valparaíso (80 km from Santiago), from where passengers travel to the capital to visit the historic Plaza de Armas, the vibrant Bellavista neighborhood, and the panoramic view from Cerro San Cristóbal.

Cruises visiting Santiago, Chile

Sailing from Santiago, Chile? See cruises departing from Santiago, Chile →

Prices per person · incl. taxes & fees.

Sailing soonest

In-depth Antarctica Falklands & South Georgia

MS Fram · Central America · 22 nights

from $23,793

$1,081 / night

In-depth Antarctica Falklands & South Georgia

MS Fram · South America · 22 nights

from $24,718

$1,123 / night

In-depth Antarctica Falklands & South Georgia

MS Fram · South America · 22 nights

from $39,977

$1,817 / night

In-depth Antarctica Falklands & South Georgia

MS Fram · Antarctica · 22 nights

from $23,741

$1,079 / night

In-depth Antarctica Falklands & South Georgia

MS Fram · Antarctica · 22 nights

from $41,676

$1,894 / night

In-depth Antarctica Falklands & South Georgia

MS Fram · Antarctica · 22 nights

from $37,382

$1,699 / night

Showing the 14 least-expensive of 14 sailings.

Showing 14 Santiago, Chile cruises

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Cruises departing from this port
View	Ship image	Cruise line	Line / Ship	Departs	Nights	From
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Nov 6, 2026	22	from $23,793 $1,081 / night
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Nov 27, 2026	22	from $24,718 $1,123 / night
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Dec 18, 2026	22	from $39,977 $1,817 / night
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Jan 8, 2027	22	from $23,741 $1,079 / night
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Jan 29, 2027	22	from $41,676 $1,894 / night
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Feb 19, 2027	22	from $37,382 $1,699 / night
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Mar 12, 2027	22	Call for price
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Jan 15, 2028	22	from $22,426 $1,019 / night
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Nov 13, 2027	22	from $19,711 $895 / night
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Feb 5, 2028	22	from $22,009 $1,000 / night
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Feb 26, 2028	22	from $21,069 $957 / night
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Mar 18, 2028	22	Call for price
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Dec 4, 2027	22	from $20,442 $929 / night
		HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions	HX Expeditions HX Expeditions line guide Search Santiago, Chile cruises on HX Expeditions MS Fram MS Fram ship guide Search cruises on MS Fram	Dec 25, 2027	22	from $22,426 $1,019 / night