Cruises departing from Santiago, Chile

14 sailings depart from Santiago, Chile

Santiago, Chile’s capital and largest city, sits in a valley surrounded by the snow-capped Andes and the Chilean Coast Range. Plaza de Armas, the grand heart of the city’s old colonial core, is home to 2 neoclassical landmarks: the 1808 Palacio de la Real Audiencia, housing the National History Museum, and the 18th-century Metropolitan Cathedral. La Chascona is the home-turned-museum of poet Pablo Neruda.

Departure port facts

Departure port facts
Departing cruises	14

Cruises from Santiago, Chile

Prices per person · incl. taxes & fees.

Showing 14 cruises from Santiago, Chile

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Upcoming cruises from this port
Cruise line	Ship	Departs	Nights	Destination	From
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Nov 6, 2026	22	Central America	from $23,793 $1,081 / night
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Nov 27, 2026	22	South America	from $24,718 $1,123 / night
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Dec 18, 2026	22	South America	from $39,977 $1,817 / night
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Jan 8, 2027	22	Antarctica	from $23,741 $1,079 / night
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Jan 29, 2027	22	Antarctica	from $41,676 $1,894 / night
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Feb 19, 2027	22	Antarctica	from $37,382 $1,699 / night
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Mar 12, 2027	22	Antarctica	Call for price
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Jan 15, 2028	22	Antarctica	from $22,426 $1,019 / night
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Nov 13, 2027	22	South America	from $19,711 $895 / night
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Feb 5, 2028	22	South America	from $22,009 $1,000 / night
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Feb 26, 2028	22	Central America	from $21,069 $957 / night
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Mar 18, 2028	22	Antarctica	Call for price
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Dec 4, 2027	22	South America	from $20,442 $929 / night
HX Expeditions HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions	MS Fram MS Fram ship guide Search cruises on MS Fram	Dec 25, 2027	22	South America	from $22,426 $1,019 / night

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