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Santiago, Chile
Photo by Francisco Kemeny on Unsplash

Cruises departing from Santiago, Chile

3 sailings depart from Santiago, Chile

Santiago, Chile’s capital and largest city, sits in a valley surrounded by the snow-capped Andes and the Chilean Coast Range. Plaza de Armas, the grand heart of the city’s old colonial core, is home to 2 neoclassical landmarks: the 1808 Palacio de la Real Audiencia, housing the National History Museum, and the 18th-century Metropolitan Cathedral. La Chascona is the home-turned-museum of poet Pablo Neruda.

Departure port facts

Departing cruises 3

Cruises from Santiago, Chile

Prices per person · incl. taxes & fees.

Showing 3 cruises from Santiago, Chile

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HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions MS Fram ship guide Search cruises on MS Fram Nov 6, 2026 22 South America

from $34,944

$1,588 / night

HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions MS Fram ship guide Search cruises on MS Fram Nov 27, 2026 22 Central America

from $24,718

$1,123 / night

HX Expeditions line guide Search cruises from Santiago, Chile on HX Expeditions MS Fram ship guide Search cruises on MS Fram Jan 8, 2027 22 South America

from $22,535

$1,024 / night