22-night South America cruise from Panama City on Seven Seas Grandeur
The Journey to the Amazon - Panama City to Panama City is a 22-night South America cruise aboard Seven Seas Grandeur, operated by Regent Seven Seas Cruises. Departing Panama City on March 9, 2027, the voyage visits 10 ports including Panama Canal, Oranjestad, Aruba, Port of Spain. Fares start from $23,449 per person.
You probably can’t think of Panama City without conjuring images of the Panama Canal. But nearly 400 years before the Panama Canal opened its locks, Panama City was making its mark. From the vestiges of the original settlement to the modern skyscrapers, experience the history and culture of one of the Pacific Coast’s oldest continuously inhabited European settlements. After exploring the bustling local markets in search of fresh fish or artisan handicrafts, admire the restored Spanish Colonial architecture in Casco Viejo. Or you can head to the Miraflores Locks and watch one of the modern world’s most heroic feats of engineering in action.
Panama Canal
Panama is synonymous with the Panama Canal. While Panama connects Central America to South America, the Panama Canal, which opened in 1914, connects the Caribbean Sea with the Pacific Ocean. The channel reduces shipping time and currently connects 160 countries and 1,700 ports around the world. Hailed as an engineering marvel, the artificial waterway with its elaborate lock system is one of the greatest achievements of the 20th century.
Arriving on an MSC Caribbean and Antilles cruise into Colón, Panama’s gateway city, you’ll encounter the irresistible juxtaposition of the ancient and modern, the artificial and natural, as enormous computerized container ships transiting the canal slice through primeval rainforests teeming with fluorescent frogs and elusive wild cats.
Book an MSC excursion to hop on a ferry that will take you along the length of the Panama Canal, through lakes and locks and past the Centennial and Americas bridges. Finally, you will arrive at Pacific port at the entrance to the Panama Canal, and then enjoy a 90-minute bus ride back to your ship.
Port of Spain
Trinidad and Tobago is an ideal place to take refuge in nature, while also enjoying the folklore, rhythms and flavours of the island enriched by its melting pot of cultures that can be traced back to Africa, India, Europe, the Middle East and China.
Well known for pristine beaches and ancient rainforests, Trinidad’s Northern Range mountains, which cover a quarter of the island, are home to almost 500 different species of birds, mammals, reptiles and fish and 620 types of butterflies. The island has been awarded the title of the world's most environmentally friendly destination, as well as the Caribbean's foremost natural attraction.
Once you arrive on an MSC Caribbean and Antilles cruise in the bustling capital of Port of Spain, book one of our scenic drives to experience breath-taking panoramic views of Port of Spain. Drive by striking buildings such as the parliament and the row of colonial houses originally built as private residences known as The Magnificent Seven. Or surround yourself with exotic trees and tropical flowers at the Royal Botanic Gardens, one of the oldest botanical gardens in the world, established in 1818.
Leaving town, journey on an MSC excursion to the edge of Trinidad's rainforest to ascend to the Mount St. Benedict's Monastery, known as the Abbey of Our Lady of Exile, 660 feet above sea level. Nestled peacefully in the mountains, the monastery was originally founded by Brazilian monks as a refuge for monks and anybody suffering religious persecution. Here your guide will provide a cultural and historical perspective of the monks who have lived a contemplative life for decades. The monastery welcomes people of all faiths.
Need to unwind? Let us take you to Maracas Bay, a popular beach lined with palm trees and surrounded by densely covered hills. It’s the ideal spot to soak up some sun.
If you’re searching for wildlife, grab your camera and join us on an MSC excursion to the Caroni Bird Sanctuary. Perfect for bird-watchers, you’ll travel along the mangroves on a flat-bottom boat or kayak and see the nesting home of the scarlet ibis and other species. Or drive through cocoa, citrus and coffee plantations to the Asa Wright Nature Centre, nestled in the Aripo Valley, for a walk through the tropical rainforest with a naturalist guide.
For more than thirty years, we have delivered unrivaled experiences throughout the world. All the while, we have been listening to our guests, evolving our services and continually refining each element of the Regent experience. Embrace the freedom enjoyed through the most all-inclusive luxury experience on the Seven Seas aboard a ship that elevates the pinnacle of ocean cruising to new heights.
Inspired by the past and stunningly reimagined for the future, Seven Seas Grandeur™ will exemplify our heritage of perfection with unrivaled space, unparalleled service, exceptional cuisine and transformative experiences that will begin the moment you step aboard.
We count visits anonymously without cookies. Accept cookies to let us remember you across visits and connect activity if you create an account, or decline and we'll still count you anonymously. Read our privacy policy
ESC
The Captain
I'm the Captain. Tell me what you're after — "Caribbean under $2,000" or "7 nights from Miami" — and I'll find the sailing and its price history.
