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11-night Mexico cruise: Panama City to Miami, Florida on Seven Seas Prestige

The Panama City to Miami, FL is a 11-night Mexico cruise aboard Seven Seas Prestige, operated by Regent Seven Seas Cruises. Departing Panama City on February 22, 2027 and arriving in Miami, Florida on March 5, 2027, the voyage visits 10 ports including Panama Canal, Puerto Limon, Roatan, Bay Islands. Fares start from $137,349 per person.

Length
11 nights
Departs
Feb 22, 2027
Returns
Mar 5, 2027
Ports of call
10
Days at sea
2

Voyage code PRT270222

Panama City

11 nights · Mexico

from $137,349 pp

via CruiseDirect

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Why this route stands out

A closer look at the journey

Panama City

You probably can’t think of Panama City without conjuring images of the Panama Canal. But nearly 400 years before the Panama Canal opened its locks, Panama City was making its mark. From the vestiges of the original settlement to the modern skyscrapers, experience the history and culture of one of the Pacific Coast’s oldest continuously inhabited European settlements. After exploring the bustling local markets in search of fresh fish or artisan handicrafts, admire the restored Spanish Colonial architecture in Casco Viejo. Or you can head to the Miraflores Locks and watch one of the modern world’s most heroic feats of engineering in action.

Panama Canal

Panama is synonymous with the Panama Canal. While Panama connects Central America to South America, the Panama Canal, which opened in 1914, connects the Caribbean Sea with the Pacific Ocean. The channel reduces shipping time and currently connects 160 countries and 1,700 ports around the world. Hailed as an engineering marvel, the artificial waterway with its elaborate lock system is one of the greatest achievements of the 20th century. Arriving on an MSC Caribbean and Antilles cruise into Colón, Panama’s gateway city, you’ll encounter the irresistible juxtaposition of the ancient and modern, the artificial and natural, as enormous computerized container ships transiting the canal slice through primeval rainforests teeming with fluorescent frogs and elusive wild cats. Book an MSC excursion to hop on a ferry that will take you along the length of the Panama Canal, through lakes and locks and past the Centennial and Americas bridges. Finally, you will arrive at Pacific port at the entrance to the Panama Canal, and then enjoy a 90-minute bus ride back to your ship.

Puerto Limon

From mountainous cloud forests and volcanoes to tropical rainforests, Costa Rica in Central America is renowned for its biodiversity and environmental conservation. When you arrive on an MSC Caribbean and Antilles cruisein Puerto Limón, you’ll discover the biggest city on Costa Rica’s Caribbean coast as well as the most important port in the country. From the port, Limón is a perfect starting point for adventurous explorers on one of many MSC excursions that will let you be one with nature in what is called Costa Rica’s Amazon. Enjoy a boat adventure down the jungle-fringed Tortuguero Canal, spotting orchids, water lilies, crocodiles, spider monkeys, manatees and otters along the way. Wave to the locals busy on the banks or in dugout canoes on the water as you pass. On another MSC excursion, spend half a day meeting some of Costa Rica’s cutest creatures: sloths. The Sloth Sanctuary of Costa Rica, founded as a not-for-profit rescue centre in 1997, lets you mingle with some of the coolest dudes in the jungle with their languid movements and permanently smiling faces. Your time at the sanctuary also includes a canoe ride along the freshwater of the Estrella River, a habitat for 180 bird species, monkeys, turtles and scores of butterflies. Soar through the tree canopy on an aerial tramway at Veragua Rainforest Research & Adventure Park, walk to a beautiful waterfall and rub shoulders with myriad butterflies, including the incredible blue morpho. Then, on this thrilling MSC excursion, zip line across 11 observation plat-forms and 9 traverses on an amazing course which has you gliding over the rainforest canopy, spotting monkeys, sloths and toucans in the trees. Or explore Afro-Caribbean culture, passing through Limón’s oldest neighbourhoods with houses on stilts and banana and cassava plantations, before watching local dancers perform to Caribbean rhythms and share Costa Rican traditions.

Price tracking

Today’s fare, in context

Price history

30 days
Fare details

Fare details

Per person · taxes & fees included
Current fares
Verified 2 days ago
Suite
$137,349
Tracked range
161 days
Price history by cabin type
CabinCurrentLowestHighest
Suite $137,349 $9,799 on Mar 25 $137,349 on Jun 6
Cabin grades
20 total
Penthouse SuiteSuite · A
Penthouse SuiteSuite · B
Penthouse SuiteSuite · C
Concierge SuiteSuite · D
Concierge SuiteSuite · E
Serenity SuiteSuite · F1
Serenity SuiteSuite · F2
Deluxe Veranda SuiteSuite · G
Grand SuiteSuite · GS
Deluxe Veranda SuiteSuite · H
Horizon Penthouse SuiteSuite · HP
SuiteSuite · I
Grand Loft SuiteSuite · LS
Prestige SuiteSuite · PS
Skyview Regent SuiteSuite · RS
Signature SuiteSuite · SG
Skyview Aura SuiteSuite · SKA
Skyview Luna SuiteSuite · SKB
Skyview Sola SuiteSuite · SKC
Seven Seas SuiteSuite · SS

○ = last seen (sold out or delisted). · Verified 2 days ago.

Lowest fares with no residency, age, or service requirement — verify eligibility at booking. How our pricing works

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

Not available

Oceanview

Not available

Balcony

Not available

Suite

from $137,349

$12,486 / night

Fare rows

Skyview Regent Suite

Cabin grade

Available

from $137,349

$12,486 / night

per person · incl. taxes & fees

Skyview Regent Suite

Cabin grade

Available

from $140,499

$12,772 / night

per person · incl. taxes & fees

Prices verified Aug 29, 2026

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The journey

11 nights, in order

Panama City

Day 1 Feb 22, 2027

Panama City

You probably can’t think of Panama City without conjuring images of the Panama Canal.

Explore Panama City

Day by day

The full itinerary

12 scheduled calls
Seven Seas Prestige

Your ship

Seven Seas Prestige

Seven Seas Prestige will be the first of two Prestige-Class ships, the second of which will be launched in 2029. The new ship class will introduce brand new accommodation categories, including a reimagination of the palatial Regent Suite, plus new dining experiences, all of which will be revealed at a later date. These new features will further enhance The Most Inclusive Luxury Experience® that Regent is known for with inclusions such as flights and transfers, gourmet cuisine in a range of specialty restaurants and al-fresco dining venues, fine wines and spirits, entertainment, unlimited internet access, free valet laundry, gratuities, one-night, pre-cruise hotel packages for guests staying in Concierge-level suites and higher and more.

6★ 77,000 GT 850 Passengers
Seven Seas Prestige ship guide Search cruises on Seven Seas Prestige

Deck plans

Deck plan for Deck 4

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More ways to take this journey

Fly-cruise options

Fly-cruise package options
Airport Price pp Included
ABQ $14,219.00 Extra
ALB $14,219.00 Extra
ATL $14,219.00 Extra
AUS $14,219.00 Extra
AVL $14,219.00 Extra
BDL $14,219.00 Extra
BFL $14,219.00 Extra
BHM $14,219.00 Extra
BIL $14,219.00 Extra
BNA $14,219.00 Extra
BOI $14,219.00 Extra
BOS $14,219.00 Extra
BUF $14,219.00 Extra
BWI $14,219.00 Extra
CHA $14,219.00 Extra
CHS $14,219.00 Extra
CID $14,219.00 Extra
CLE $14,219.00 Extra
CLT $14,219.00 Extra
CMH $14,219.00 Extra
COS $14,219.00 Extra
CVG $14,219.00 Extra
DCA $14,219.00 Extra
DEN $14,219.00 Extra
DFW $14,219.00 Extra
DSM $14,219.00 Extra
DTW $14,219.00 Extra
ELP $14,219.00 Extra
EUG $14,219.00 Extra
EWR $14,219.00 Extra
FAR $14,219.00 Extra
FAT $14,219.00 Extra
FLL $13,819.00 Extra
FSD $14,219.00 Extra
GEG $14,219.00 Extra
GRR $14,219.00 Extra
GSO $14,219.00 Extra
GSP $14,219.00 Extra
GTF $14,219.00 Extra
HNL $14,219.00 Extra
HSV $14,219.00 Extra
IAD $14,219.00 Extra
IAH $14,219.00 Extra
ICT $14,219.00 Extra
ILM $14,219.00 Extra
IND $14,219.00 Extra
JAN $14,219.00 Extra
JAX $14,219.00 Extra
JFK $14,219.00 Extra
LAS $14,219.00 Extra
LAX $14,219.00 Extra
LBB $14,219.00 Extra
LEX $14,219.00 Extra
LGA $14,219.00 Extra
LIT $14,219.00 Extra
MAF $14,219.00 Extra
MCI $14,219.00 Extra
MCO $14,219.00 Extra
MDW $14,219.00 Extra
MEM $14,219.00 Extra
MIA $13,819.00 Extra
MKE $14,219.00 Extra
MOB $14,219.00 Extra
MSN $14,219.00 Extra
MSP $14,219.00 Extra
MSY $14,219.00 Extra
MYR $14,219.00 Extra
OKC $14,219.00 Extra
OMA $14,219.00 Extra
ORD $14,219.00 Extra
ORF $14,219.00 Extra
PBI $13,819.00 Extra
PDX $14,219.00 Extra
PHL $14,219.00 Extra
PHX $14,219.00 Extra
PIA $14,219.00 Extra
PIT $14,219.00 Extra
PSP $14,219.00 Extra
PVD $14,219.00 Extra
PWM $14,219.00 Extra
RDU $14,219.00 Extra
RIC $14,219.00 Extra
RNO $14,219.00 Extra
ROC $14,219.00 Extra
RSW $13,819.00 Extra
SAN $14,219.00 Extra
SAT $14,219.00 Extra
SAV $14,219.00 Extra
SBA $14,219.00 Extra
SDF $14,219.00 Extra
SEA $14,219.00 Extra
SFO $14,219.00 Extra
SGF $14,219.00 Extra
SHV $14,219.00 Extra
SLC $14,219.00 Extra
SMF $14,219.00 Extra
SNA $14,219.00 Extra
STL $14,219.00 Extra
SYR $14,219.00 Extra
TPA $14,219.00 Extra
TUL $14,219.00 Extra
TUS $14,219.00 Extra
TYS $14,219.00 Extra
XNA $14,219.00 Extra
YEG $14,219.00 Extra
YOW $14,219.00 Extra
YUL $14,219.00 Extra
YVR $14,219.00 Extra
YYC $14,219.00 Extra
YYJ $14,219.00 Extra
YYZ $14,219.00 Extra

from $137,349 pp

via CruiseDirect

Book with CruiseDirect

Book direct with Regent Seven Seas Cruises we may earn a commission