20-night Mediterranean cruise: Genoa, Italy to Buenos Aires on MSC Splendida
The 20 nights South America from Genoa (Portofino) is a 20-night Mediterranean cruise aboard MSC Splendida, operated by MSC Cruises. Departing Genoa, Italy on November 15, 2027 and arriving in Buenos Aires on December 5, 2027, the voyage visits 9 ports including Civitavecchia, Rome, Barcelona, Malaga. Fares start from $1,969 per person.
Fixed editorial images from the places on this itinerary. They stay stable each time you return to this sailing.
Genoa, Italy
Genoa is marvellously eclectic, vibrant and full of rough-edged style; it’s a great cruise excursion.
Indeed “La Superba” (The Superb), as it was known at the height of its authority as a Mediterranean superpower, boasts more zest and intrigue than all the surrounding coastal resorts put together.
During a holiday to Genoa you can explore its old town: a dense and fascinating warren of medieval alleyways home to large palazzi built in the sixteenth and seventeenth centuries by Genoa’s wealthy mercantile families and now transformed into museums and art galleries. You should seek out the Cattedrale di San Lorenzo, the Palazzo Ducale, and the Renaissance palaces of Via Garibaldi which contain the cream of Genoa’s art collections, as well as furniture and decor from the grandest days of the city’s past, when its ships sailed to all corners of the Mediterranean Sea.
The Acquario di Genova is the city’s pride and joy, parked like a giant ocean liner on the waterfront, with seventy tanks housing sea creatures from all the world’s major habitats, including the world’s biggest reconstruction of a Caribbean coral reef. It’s a great aquarium by any standards, the second largest in Europe by capacity, and boasts a fashionably ecology-conscious slant and excellent background information in Italian and English.
Just 35 km south of Genoa, there’s no denying the appeal of Portofino, tucked into a protected inlet surrounded by lush cypress- and olive-clad slopes. It’s an A-list resort that has been attracting high-flying bankers, celebs and their hangers-on for years, as evidenced by the flotillas of giant yachts usually anchored just outside. It’s a tiny place that is attractive yet somehow off-putting at the same time, with a quota of fancy shops, bars and restaurants for a place twice its size.
Civitavecchia, Rome
All roads lead to Rome, and with good reason - this city is one of the world’s most thrilling, offering unmatched history along every street. An evocative, inspiring and utterly artistic capital of unrivalled cultural impact, Rome is a city of back-to-back landmarks, which will take you on an exhilarating journey through the ages. This may be one of the world’s oldest cities, but it’s well and truly lived in. The ruins are punctuated with murmuring cafes, and the outdoor seating of restaurants sprawls out across piazzas, enticing you to sample tangles of creamy pasta and crispy pizzas. Rome’s incredible Roman Forum is littered with the ruins of its ancient administrations, which have stood firm for 2,000 years, since the times when the area was the centre of the Western world. Few sites are more simultaneously beautiful and haunting than that of the storied Colosseum, which looms deep into Rome’s rich blue sky. Take a tour to learn details of the grisly goings-on within. The best way to experience Rome is to wander its streets, gelato in hand. There is a lot to see here - whether it’s the domed spectacle of the Pantheon, or the elaborate flowing waters and artistry of the Trevi Fountain. Vatican City is an astonishing, colossal display of Catholic grandeur, while the Spanish Steps – crowned by the Trinità dei Monti church – offer a beautiful spot to gather and soak up the lively atmosphere of this humming city. With so much on the to-do list, you’ll relish the breaks you take, enjoying simple pleasures like a strong espresso, or fresh pasta with tomato sauce and ripped basil.
Barcelona
On the northeast coast of Spain, overlooking the Mediterranean, Barcelona is a vibrant port city, packed with centuries of iconic art and architecture—Gaudí and Picasso both called it home—and lined with sunny white-sand beaches. Explore the Catalan capital's tourist attractions and historic neighborhoods, Modernisme and world-renowned art museums, galleries and local crafts shops—some of which are centuries old and stock traditional Catalan wares. After you see the sights, there are lively tapas bars around every corner where you can stop for a drink, a café amb llet (Catalan for espresso with steamed milk) or a snack, no matter the hour. Green spaces for picnics, long walks and respite from the hustle and bustle are scattered throughout Barcelona's attractions: There's Gaudí's mosaic-decorated park, a neoclassical maze at the Laberint d'Horta, as well as plenty of high places (mountains, monuments and edifices) where sightseeing visitors can take in the view. A short trip from Barcelona by car or train, luxury outlets, cava wineries, a mountaintop abbey and the sandy beaches of the Mediterranean coast await.
Msc Yacht Club Yacht Club Executive and Family Suite with Balcony
Cabin grade
Available
from $12,939
$646 / night
per person · incl. taxes & fees
Msc Yacht Club Yacht Club Executive and Family Suite with Balcony
Cabin grade
Available
from $12,939
$646 / night
per person · incl. taxes & fees
Msc Yacht Club Yacht Club Executive and Family Suite with Balcony
Cabin grade
Available
from $12,939
$646 / night
per person · incl. taxes & fees
MSC YACHT CLUB DELUXE SUITE
Cabin grade
Available
from $14,418
$720 / night
per person · incl. taxes & fees
MSC YACHT CLUB GRAND SUITE
Cabin grade
Available
from $15,758
$787 / night
per person · incl. taxes & fees
MSC YACHT CLUB EXECUTIVE & FAMILY SUITE
Cabin grade
Available
from $18,418
$920 / night
per person · incl. taxes & fees
Msc Yacht Club Yacht Club Executive and Family Suite with Balcony
Cabin grade
Available
from $25,778
$1,288 / night
per person · incl. taxes & fees
Prices verified Aug 26, 2026
Prices come from third-party data feeds via MSC Cruises and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works
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MSC Splendida carries you in stylish luxury to the most desirable cruise destinations in the world.
You’ll love the live music and wide variety of bars and restaurants on board. Food choices to explore include authentic Mediterranean specialities and spicy Tex-Mex. Complete the night with a world-class show in The Strand Theatre, a winning streak in the Royal Palm Casino or dancing ‘til dawn in the Club 33 Disco.
We’ve got fitness and sport covered with four swimming pools, a squash court, volleyball court, ultramodern gym and even a running track, allowing you to take in the stunning ocean views and refreshing sea breeze.
For those looking to relax, head to the MSC Aurea Spa where you will find pampering Balinese massages, a range of beauty treatments, a Turkish bath, sauna, whirlpool and solarium. There is also the option to sunbathe in peace on the Top 18 sun deck, located at the top of the ship, where complimentary, refreshing fruit skewers and a thirst-quenching bar menu will keep you cool all day.
And while you are topping up your tan, the Kids and Teens can enjoy fabulous facilities and clubs of their own.
The foredecks of the ship are home to the exclusive MSC Yacht Club, a luxurious ship-within-a-ship with 71 spacious suites, its own Concierge Reception, 24-hour butler service, private Top Sail Lounge, pool deck and bar.
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