10-Day Greek Isles: Istanbul Overnight with Santorini

The 10-Day Greek Isles: Istanbul Overnight with Santorini is a 10-night Mediterranean cruise aboard Oosterdam, operated by Holland America Line. Departing Athens (Piraeus), Greece on October 2, 2027, the voyage visits 7 ports. Fares start from $2,719 per person.

Length: 10 nights
Departs: Oct 2, 2027
Returns: Oct 12, 2027
Ports of call: 7
Days at sea: 3

from $2,719

$271 / night per person, incl. taxes & fees

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Itinerary

Day 1 Oct 2, 2027 Athens (Piraeus), Greece Departs 17:00 A city of legend, civilisation and enduring culture, Athens is a majestic and magical urban sprawl. Extraordinary elegance and grace combine with grit and graft in Greece's capital, where highways encase ruins from antiquity, and gleaming museums and galleries stand beside concrete sprayed with edgy street art. These contrasts enhance and elevate the wonders of this 2,500-year-old city, however, which can count notable contributions to philosophy, drama and democracy, among its global legacy. Piraeus' giant port and naval base welcome you to the edge of the Athens' urban area. From there it's a simple jaunt to the centre. The majestic ancient citadel of the Acropolis dominates an elevated platform and is a constant presence as you explore the city. The wonderful remains of the columned temple of the Parthenon - which date back to the 5th century BC - stand here, representing the pinnacle of classical architecture. The nearby Acropolis Museum adds context to your visit and frames the broad views from its giant glass windows. Or rise up Mount Lycabettus, to be rewarded with perhaps Athens' best panorama of the Acropolis sitting high over the city on its grand stage. See the marble horseshoe of the Old Olympic Stadium, where the first modern Olympics were held in 1896, for more of the city's enduring legacy. Elsewhere, golden beaches and temples stretch out along the coastline, should you wish to explore a little further afield. Coffee is an art form to the Greeks, and it's an unwritten rule that coffee time must never be rushed. So prepare to settle down for a couple of hours and lose yourself in a good chat. Feeling hungry - try traditional souvlaki made with sauces handed from generation to generation. Athens (Piraeus), Greece port guide Search cruises visiting Athens (Piraeus), Greece

Day 2 Oct 3, 2027 Mykonos 07:00 – 20:00 13.0 hrs ashore Think of a trip to Greece and you will imagine Mykonos. The port of Mykonos, or perhaps it would be more correct to say of Chora, is located on the west coast of the island. The Cyclades islands in the Aegean are wonderful and the beaches are no less marvellous, with the pleasant distinction of being among the most festive in the archipelago. After docking at the port of Mykonos, enjoy the numerous natural coves, beaches and cliffs of this beautiful island. You can enjoy the clean, azure sea of Paradise Beach, while in the evening let yourself be carried away by the rhythm of this cosmopolitan and youthful island. The harbour district, the Kastro, is known as the 'little Venice'. In its alleys, the shops and restaurants alternate with white houses with blue doors and windows. On a trip to Mykonos, take advantage of the stop to go on shore excursions, stroll through the maze of streets and alleys where you can discover the beauty of the architecture and the design of the city. The small white houses with shutters as blue as the sky, the pigeon houses and the numerous small churches of Mykonos will simply enchant you. Mykonos port guide Search cruises visiting Mykonos

Mykonos photo — Day 2 Oct 3, 2027 Mykonos 07:00 – 20:00 13.0 hrs ashore Think of a trip to Greece and you will imagine Mykonos. The port of Mykonos, or perhaps it would be more correct to say of Chora, is located on the west coast of the island. The Cyclades islands in the Aegean are wonderful and the beaches are no less marvellous, with the pleasant distinction of being among the most festive in the archipelago. After docking at the port of Mykonos, enjoy the numerous natural coves, beaches and cliffs of this beautiful island. You can enjoy the clean, azure sea of Paradise Beach, while in the evening let yourself be carried away by the rhythm of this cosmopolitan and youthful island. The harbour district, the Kastro, is known as the 'little Venice'. In its alleys, the shops and restaurants alternate with white houses with blue doors and windows. On a trip to Mykonos, take advantage of the stop to go on shore excursions, stroll through the maze of streets and alleys where you can discover the beauty of the architecture and the design of the city. The small white houses with shutters as blue as the sky, the pigeon houses and the numerous small churches of Mykonos will simply enchant you. Mykonos port guide Search cruises visiting Mykonos

Day 4 Oct 5, 2027 Istanbul Arrives 07:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Istanbul port guide Search cruises visiting Istanbul

Istanbul photo — Day 4 Oct 5, 2027 Istanbul Arrives 07:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Istanbul port guide Search cruises visiting Istanbul

Day 8 Oct 9, 2027 Chania, Crete 08:00 – 18:00 10.0 hrs ashore The port of Souda on the Aegean Sea is home to a Greek and NATO naval base and is located six kilometers (three miles) from Chania—the second-largest city on Crete, which itself is the largest of the Greek Islands. Once you’re in Chania, set your compass for the historic waterfront with its famous Venetian Harbor dating to the 14th century. Walk along the breakwater to the restored 500-year-old lighthouse for views that are particularly photogenic from late afternoon until sunset. The atmospheric tangle of streets that is Old Town is easily explored on foot, and you can stop at one of the many outdoor cafés for a bouyatsa (custard pastry) or a glass of Cretan red wine.Soúda can also be a jumping-off point for a visit to Rethymnon, located about 54 kilometers (33 miles) to the east. Shaped by centuries of invasion, namely by the Venetians and Turks, its Fortezza was built by the Venetians in the late 16th century and captured by the Ottomans in 1646. The Old Town has the same kind of architectural character as Chania, but on a smaller scale. Chania, Crete port guide Search cruises visiting Chania, Crete

Chania, Crete photo — Day 8 Oct 9, 2027 Chania, Crete 08:00 – 18:00 10.0 hrs ashore The port of Souda on the Aegean Sea is home to a Greek and NATO naval base and is located six kilometers (three miles) from Chania—the second-largest city on Crete, which itself is the largest of the Greek Islands. Once you’re in Chania, set your compass for the historic waterfront with its famous Venetian Harbor dating to the 14th century. Walk along the breakwater to the restored 500-year-old lighthouse for views that are particularly photogenic from late afternoon until sunset. The atmospheric tangle of streets that is Old Town is easily explored on foot, and you can stop at one of the many outdoor cafés for a bouyatsa (custard pastry) or a glass of Cretan red wine.Soúda can also be a jumping-off point for a visit to Rethymnon, located about 54 kilometers (33 miles) to the east. Shaped by centuries of invasion, namely by the Venetians and Turks, its Fortezza was built by the Venetians in the late 16th century and captured by the Ottomans in 1646. The Old Town has the same kind of architectural character as Chania, but on a smaller scale. Chania, Crete port guide Search cruises visiting Chania, Crete

Day 10 Oct 11, 2027 Messina, Italy 07:00 – 13:00 6.0 hrs ashore Messina may well be your first sight of Sicily, and – from your MSC holiday cruise ship – it’s a fine one, the glittering town spread up the hillside beyond its sickle-shaped Mediterranean harbour. On a shore excursion you can discover Messina’s most important monument, the Duomo, which epitomizes the city’s phoenix-like ability to re-create itself from the ashes of its last disaster. It’s the reconstruction of a twelfth-century cathedral erected by Roger II, one of a series of great Norman churches of Sicily that include the sumptuous cathedrals of Palermo and Cefalù. The Duomo’s detached campanile, or bell tower, claims to be the largest astronomical clock in the world, and puts on its best show at noon every day, when a bronze lion (Messina’s ancient emblem) unleashes a mighty roar over the city that can be quite alarming if you’re not expecting it! Just back from the Duomo, the truncated section of the twelfth-century Chiesa Annunziata dei Catalani squats below pavement level, and is Messina’s only surviving example of Arab/Norman church-building. When you are cruising the Mediterranean Sea with MSC Cruises, the most obvious excursion from Messina is to the almost too charming hill town of Taormina, spectacularly located on a rocky bluff between the Ionian Sea and the soaring peak of Mount Etna, whose summit with its bleak lava wilderness is one of the most memorable landscapes Italy has to offer. Once the beloved retreat of poets and writers, Taormina is now the most illustrious resort on the entire island, captivating its visitors with its famous ancient theatre, grand hotels and engaging small-town charm. Messina, Italy port guide Search cruises visiting Messina, Italy

Messina, Italy photo — Day 10 Oct 11, 2027 Messina, Italy 07:00 – 13:00 6.0 hrs ashore Messina may well be your first sight of Sicily, and – from your MSC holiday cruise ship – it’s a fine one, the glittering town spread up the hillside beyond its sickle-shaped Mediterranean harbour. On a shore excursion you can discover Messina’s most important monument, the Duomo, which epitomizes the city’s phoenix-like ability to re-create itself from the ashes of its last disaster. It’s the reconstruction of a twelfth-century cathedral erected by Roger II, one of a series of great Norman churches of Sicily that include the sumptuous cathedrals of Palermo and Cefalù. The Duomo’s detached campanile, or bell tower, claims to be the largest astronomical clock in the world, and puts on its best show at noon every day, when a bronze lion (Messina’s ancient emblem) unleashes a mighty roar over the city that can be quite alarming if you’re not expecting it! Just back from the Duomo, the truncated section of the twelfth-century Chiesa Annunziata dei Catalani squats below pavement level, and is Messina’s only surviving example of Arab/Norman church-building. When you are cruising the Mediterranean Sea with MSC Cruises, the most obvious excursion from Messina is to the almost too charming hill town of Taormina, spectacularly located on a rocky bluff between the Ionian Sea and the soaring peak of Mount Etna, whose summit with its bleak lava wilderness is one of the most memorable landscapes Italy has to offer. Once the beloved retreat of poets and writers, Taormina is now the most illustrious resort on the entire island, captivating its visitors with its famous ancient theatre, grand hotels and engaging small-town charm. Messina, Italy port guide Search cruises visiting Messina, Italy

Day 11 Oct 12, 2027 Civitavecchia, Rome Arrives 07:00 All roads lead to Rome, and with good reason - this city is one of the world’s most thrilling, offering unmatched history along every street. An evocative, inspiring and utterly artistic capital of unrivalled cultural impact, Rome is a city of back-to-back landmarks, which will take you on an exhilarating journey through the ages. This may be one of the world’s oldest cities, but it’s well and truly lived in. The ruins are punctuated with murmuring cafes, and the outdoor seating of restaurants sprawls out across piazzas, enticing you to sample tangles of creamy pasta and crispy pizzas. Rome’s incredible Roman Forum is littered with the ruins of its ancient administrations, which have stood firm for 2,000 years, since the times when the area was the centre of the Western world. Few sites are more simultaneously beautiful and haunting than that of the storied Colosseum, which looms deep into Rome’s rich blue sky. Take a tour to learn details of the grisly goings-on within. The best way to experience Rome is to wander its streets, gelato in hand. There is a lot to see here - whether it’s the domed spectacle of the Pantheon, or the elaborate flowing waters and artistry of the Trevi Fountain. Vatican City is an astonishing, colossal display of Catholic grandeur, while the Spanish Steps – crowned by the Trinità dei Monti church – offer a beautiful spot to gather and soak up the lively atmosphere of this humming city. With so much on the to-do list, you’ll relish the breaks you take, enjoying simple pleasures like a strong espresso, or fresh pasta with tomato sauce and ripped basil. Civitavecchia, Rome port guide Search cruises visiting Civitavecchia, Rome

Pricing

Lowest fare we've tracked over the observed 74-day span: $2,719 · range $2,719–$2,719

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $2,719

$271 / night

Fare rows

Standard Interior Stateroom

Cabin grade

Available

from $2,719

$271 / night

per person · incl. taxes

Large/Standard Inside Stateroom

Cabin grade

Available

from $2,749

$274 / night

per person · incl. taxes

Standard Interior Stateroom

Cabin grade

Available

from $2,779

$277 / night

per person · incl. taxes

Standard Interior Stateroom

Cabin grade

Available

from $2,809

$280 / night

per person · incl. taxes

Large/Standard Inside Stateroom

Cabin grade

Available

from $2,839

$283 / night

per person · incl. taxes

Large Interior Stateroom

Cabin grade

Available

from $2,869

$286 / night

per person · incl. taxes

Large/Standard Inside Stateroom

Cabin grade

Available

from $2,899

$289 / night

per person · incl. taxes

Oceanview

from $2,869

$286 / night

Fare rows

Large Ocean view Stateroom (Fully Obstructed View)

Cabin grade

Available

from $2,869

$286 / night

per person · incl. taxes

Large Ocean view Stateroom (Fully Obstructed View)

Cabin grade

Available

from $2,919

$291 / night

per person · incl. taxes

Large Ocean view Stateroom (Partial Sea View)

Cabin grade

Available

from $2,949

$294 / night

per person · incl. taxes

Large Ocean view Stateroom

Cabin grade

Available

from $2,969

$296 / night

per person · incl. taxes

Large Ocean view Stateroom

Cabin grade

Available

from $3,019

$301 / night

per person · incl. taxes

Large Ocean view Stateroom

Cabin grade

Available

from $3,049

$304 / night

per person · incl. taxes

Large Ocean view Stateroom

Cabin grade

Available

from $3,079

$307 / night

per person · incl. taxes

Large Ocean view Stateroom

Cabin grade

Available

from $3,109

$310 / night

per person · incl. taxes

Balcony

from $3,579

$357 / night

Fare rows

Verandah Stateroom

Cabin grade

Available

from $3,579

$357 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $3,669

$366 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $3,759

$375 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $3,829

$382 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $3,899

$389 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $3,969

$396 / night

per person · incl. taxes

Verandah Stateroom

Cabin grade

Available

from $4,039

$403 / night

per person · incl. taxes

Suite

from $4,869

$486 / night

Fare rows

Signature Suite

Cabin grade

Available

from $4,869

$486 / night

per person · incl. taxes

Signature Suite

Cabin grade

Available

from $5,059

$505 / night

per person · incl. taxes

Signature Suite

Cabin grade

Available

from $5,249

$524 / night

per person · incl. taxes

Neptune Suite

Cabin grade

Available

from $5,719

$571 / night

per person · incl. taxes

Neptune Suite

Cabin grade

Available

from $6,109

$610 / night

per person · incl. taxes

Neptune Suite

Cabin grade

Available

from $6,499

$649 / night

per person · incl. taxes

Pinnacle Suite

Cabin grade

Available

from $10,469

$1,046 / night

per person · incl. taxes

Prices verified Jun 24, 2026

Prices come from third-party data feeds via Holland America Line and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

Show all 29 cabin grades

Name	Supplier code	Type
Verandah Stateroom	VA	Balcony
Verandah Stateroom	VB	Balcony
Verandah Stateroom	VC	Balcony
Verandah Stateroom	VD	Balcony
Verandah Stateroom	VE	Balcony
Verandah Stateroom	VF	Balcony
Verandah Stateroom	VH	Balcony
Large/Standard Inside Stateroom	I	Inside
Large Interior Stateroom	J	Inside
Large/Standard Inside Stateroom	K	Inside
Standard Interior Stateroom	L	Inside
Standard Interior Stateroom	M	Inside
Large/Standard Inside Stateroom	MM	Inside
Standard Interior Stateroom	N	Inside
Large Ocean view Stateroom	C	Oceanview
Large Ocean view Stateroom	D	Oceanview
Large Ocean view Stateroom	DD	Oceanview
Large Ocean view Stateroom	E	Oceanview
Large Ocean view Stateroom	F	Oceanview
Large Ocean view Stateroom (Partial Sea View)	G	Oceanview
Large Ocean view Stateroom (Fully Obstructed View)	H	Oceanview
Large Ocean view Stateroom (Fully Obstructed View)	HH	Oceanview
Pinnacle Suite	PS	Suite
Neptune Suite	SA	Suite
Neptune Suite	SB	Suite
Neptune Suite	SC	Suite
Signature Suite	SS	Suite
Signature Suite	SY	Suite
Signature Suite	SZ	Suite