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Colon, Panama
Photo by Sol Cerrud on Unsplash

Colon, Panama cruise port guide

Panama is synonymous with the Panama Canal. While Panama connects Central America to South America, the Panama Canal, which opened in 1914, connects the Caribbean Sea with the Pacific Ocean. The channel reduces shipping time and currently connects 160 countries and 1,700 ports around the world. Hailed as an engineering marvel, the artificial waterway with its elaborate lock system is one of the greatest achievements of the 20th century. Arriving on an MSC Caribbean and Antilles cruise into Colón, Panama’s gateway city, you’ll encounter the irresistible juxtaposition of the ancient and modern, the artificial and natural, as enormous computerized container ships transiting the canal slice through primeval rainforests teeming with fluorescent frogs and elusive wild cats. Book an MSC excursion to hop on a ferry that will take you along the length of the Panama Canal, through lakes and locks and past the Centennial and Americas bridges. Finally, you will arrive at Pacific port at the entrance to the Panama Canal, and then enjoy a 90-minute bus ride back to your ship. Not far from the ceaseless activity on the canal lies untamed nature. Take a guided eco-cruise on Gatún Lake, surrounded by rainforest. Gatún, created in 1913 to fill the fertile valley of the Chagres River, is the world's largest artificial lake, and an integral part of the dam and canal. Catch glimpses of exotic birds, monkeys, sloths, iguanas, crocodiles and more. Following your lake cruise, go on a rainforest walk and follow the eco-trail that surrounds the lake. Head off the beaten path on an MSC excursion to explore the world of the Emberá people, located only half an hour by dugout up the Chagres River. Emberá villagers, who live much as they did when the Spanish arrived in the 1500s, will welcome you in traditional dress, with dances, music and their artefacts: baskets, jewellery and the cocobolo, a small sculpture made from a special kind of wood. The Colón cruise also gives you the opportunity to discover bustling Panama City, the country’s capital, with its pleasant blend of modern and colonial architecture. Enjoy a scenic visit to Panama City’s cobblestoned historic centre, Casco Viejo, or the Colonial City, declared a World Heritage Site by UNESCO. Founded in 1673, the Casco Viejo, or Casco Antiguo as it is also called, was built following the near-total destruction of the original Panama City two years earlier, when it was attacked by an Englishman, Captain Henry Morgan. The Casco Antiguo brims with historical buildings, including a cathedral and national theatre, a French monument to the 22,000 workers who died building the Panama Canal, and the fabulous Las Bóvedas walkway. The tour also includes a quick visit to Agua Claras Locks (Expansion Centre) to see how the Panama Canal operates.

About Colon, Panama

Colón sits at the Caribbean (Atlantic) entrance to the Panama Canal and serves as a major port and free-trade zone. The nearby Port of Balboa on the Pacific side is the canal's Pacific terminus, ranked the busiest container port in Latin America in 2012 with 5 million TEU capacity. The Panama Canal Railway connects Colón with Balboa/Panama City for multimodal freight and a daily passenger service.

Quick facts

Coordinates 9.3586, -79.9000
Available cruises 306

Cruises visiting Colon, Panama

Prices per person · incl. taxes & fees.

Showing the 20 least-expensive of 306 sailings.

Showing 306 Colon, Panama cruises

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Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Apr 24, 2027 7

from $585

$83 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Nov 8, 2026 6

from $737

$122 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Sep 26, 2026 7

from $743

$106 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Oct 3, 2026 7

from $749

$107 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Sep 5, 2026 7

from $796

$113 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Sep 12, 2026 7

from $801

$114 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Oct 24, 2026 7

from $813

$116 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Oct 10, 2026 7

from $822

$117 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Nov 7, 2026 7

from $825

$117 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Oct 17, 2026 7

from $825

$117 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Oct 31, 2026 7

from $840

$120 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Sep 19, 2026 7

from $847

$121 / night

Go to Carnival Cruise Line Colon, Panama cruises on Carnival Cruise Line Go to Carnival Cruise Line Colon, Panama cruises on Carnival Cruise Line Go to Carnival Sunshine Cruises on Carnival Sunshine Jan 3, 2028 10

from $850

$85 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Aug 15, 2026 7

from $852

$121 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Aug 29, 2026 7

from $884

$126 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Feb 5, 2028 7

from $886

$126 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Feb 26, 2028 7

from $886

$126 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Feb 12, 2028 7

from $886

$126 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Feb 19, 2028 7

from $887

$126 / night

Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Royal Caribbean Colon, Panama cruises on Royal Caribbean Go to Grandeur of the Seas Cruises on Grandeur of the Seas Feb 13, 2027 7

from $889

$127 / night