Cape Girardeau, MO cruise port guide
About Cape Girardeau, MO
Cape Girardeau is a city on the Mississippi River in southeast Missouri, a port of call for river cruise ships navigating the Mississippi system. American Cruise Lines operates paddlewheel cruise ships on much of the Mississippi system.
Quick facts
Cruises visiting Cape Girardeau, MO
Prices per person · incl. taxes & fees.
Sailing soonest
Nashville, Memphis & the Cumberland from Nashville
Viking Mississippi · North America · 7 nights
from $5,499
$785 / night
Nashville, Memphis & the Cumberland from Nashville
Viking Mississippi · North America · 7 nights
from $4,799
$685 / night
Mississippi River Odyssey
Viking Mississippi · North America · 21 nights
Call for price
Mississippi River Odyssey
Viking Mississippi · North America · 21 nights
Call for price
Mississippi River Odyssey
Viking Mississippi · North America · 21 nights
from $15,998
$761 / night
Nashville, Memphis & the Cumberland from Memphis
Viking Mississippi · North America · 7 nights
from $6,999
$999 / night
Showing the 8 least-expensive of 8 sailings.
Showing 8 Cape Girardeau, MO cruises
Open in full search| View | Ship image | Cruise line | Line / Ship | Departs | Nights | From |
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Nov 3, 2026 | 7 |
from $5,499 $785 / night |
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Nov 17, 2026 | 7 |
from $4,799 $685 / night |
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Jun 22, 2027 | 21 |
Call for price |
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Jul 27, 2027 | 21 |
Call for price |
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Oct 19, 2027 | 7 |
from $6,999 $999 / night |
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Oct 26, 2027 | 7 |
from $6,999 $999 / night |
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Nov 9, 2027 | 7 |
from $5,999 $857 / night |
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Aug 10, 2027 | 21 |
from $15,998 $761 / night |
