Panama Canal & Latin America Cruise: Mexico, Costa Rica & Colombia

17 nights May 24, 2027

The Panama Canal & Latin America Cruise: Mexico, Costa Rica & Colombia is a 17-night South America cruise aboard Azamara Quest, operated by Azamara. Departing San Diego, California on May 24, 2027, the voyage visits 8 ports. Fares start from $5,779 per person.

from $5,779

$339 / night per person, incl. taxes & fees

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from $5,779 pp

Continues on Azamara's site

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Itinerary

Day 1 May 24, 2027 San Diego, California Departs 20:00 Free from smog and jungle-like freeways, San Diego sits gracefully around a beautiful curving bay. Although affluent and conservative, this second largest city in California is also amiable and easygoing. San Diego has a vibrant and active downtown area, and since the late 1970s several blocks of early 20th century architecture have been stylishly renovated, while the sleek modern bank buildings symbolize the city's growing economic significance on the Pacific Rim. San Diego is the birthplace of California. Portuguese explorer Juan Rodrigues Cabrillo landed here in 1542; since then, San Diego has been under Spanish, Mexican and after 1846, American rule. The city really took off with the arrival of the Santa Fe Railroad in the 1880s, but in terms of trade and significance it has long played second fiddle to Los Angeles. However, during World War II the U.S. Navy made San Diego their Pacific Command Center and the military continue to dominate the local economy, along now with tourism. Within easy reach of the downtown area, encompassing 1,400 acres of cultural, recreational and environmental delights, San Diego's Balboa Park is a sumptuous place with trees, gardens, traffic-free promenades and a large concentration of Spanish-colonial style buildings. The Hillcrest area is the lively and artsy center of the city, and Old Town San Diego is now a historical park where the city's Spanish and Mexican history and heritage are most evident. The Gaslamp Quarter, once the heart of frontier San Diego, is today filled with smart streets lined with chic cafés, antique stores, art galleries and gas lamps (powered by electricity). Most of the eastern part of the county is taken up by the 600,000-acre Anza-Borrego Desert. Another must-see is the city's most famous attraction, the San Diego Zoo. Go to San Diego, California Cruises visiting San Diego, California

Day 4 May 27, 2027 Cabo San Lucas 08:00 – 17:00 9.0 hrs ashore Found at the tip of Baja California, Cabo San Lucas is where the desert meets the ocean. Although it has received a makeover of modern Americana in recent years, this place is still a world away from everywhere else in Mexico. A trip to Cabo (the San Lucas is optional) will not leave you disappointed. With swaying palm trees, turquoise seas and long ribbons of white sand, this is a resort that ticks every box: great food, great nightlight which equal great times – for some. Others may prefer to scratch the surface just a bit deeper and travel along the peninsula that is known for its dramatic scenery of desert terrain and rugged coastline marked by many unusual formations. The sweeping views of the bay are simply sensational. A quick turn inward takes you to San Jose del Cabo, Cabo San Lucas’ older and more grown up sister. Offering a very much calmer and much more authentic atmosphere, just half an hour along the coast leaves you in its desert terrain, and leaves a very different impression from the lively beachfront bars and cafes of San Lucas. Perhaps one of the most stunning ways to see Cabo though is from the water. With the Arco de Cabo San Lucas featuring highly on many must-see lists, a trip around the bay is a must. The braver among you might also like to indulge their inner adrenalin junkie and swim with whale sharks – a memorable and totally risk-free experience if there ever was one. End your day of sightseeing with a fabulous sunset, a (tequila) sunrise in hand, watching the fishermen come home from their adventures. Go to Cabo San Lucas Cruises visiting Cabo San Lucas

Cabo San Lucas photo — Day 4 May 27, 2027 Cabo San Lucas 08:00 – 17:00 9.0 hrs ashore Found at the tip of Baja California, Cabo San Lucas is where the desert meets the ocean. Although it has received a makeover of modern Americana in recent years, this place is still a world away from everywhere else in Mexico. A trip to Cabo (the San Lucas is optional) will not leave you disappointed. With swaying palm trees, turquoise seas and long ribbons of white sand, this is a resort that ticks every box: great food, great nightlight which equal great times – for some. Others may prefer to scratch the surface just a bit deeper and travel along the peninsula that is known for its dramatic scenery of desert terrain and rugged coastline marked by many unusual formations. The sweeping views of the bay are simply sensational. A quick turn inward takes you to San Jose del Cabo, Cabo San Lucas’ older and more grown up sister. Offering a very much calmer and much more authentic atmosphere, just half an hour along the coast leaves you in its desert terrain, and leaves a very different impression from the lively beachfront bars and cafes of San Lucas. Perhaps one of the most stunning ways to see Cabo though is from the water. With the Arco de Cabo San Lucas featuring highly on many must-see lists, a trip around the bay is a must. The braver among you might also like to indulge their inner adrenalin junkie and swim with whale sharks – a memorable and totally risk-free experience if there ever was one. End your day of sightseeing with a fabulous sunset, a (tequila) sunrise in hand, watching the fishermen come home from their adventures. Go to Cabo San Lucas Cruises visiting Cabo San Lucas

Day 8 May 31, 2027 Puerto Quetzal 09:30 – 20:00 10.5 hrs ashore A voyage between fire and water, between majestic volcanoes and stunning lakes. There are so many colors, you can get lost in them, from the bright traditional clothes of the people to the church facades. Everything is a rainbow of life in Guatemala, starting from Puerto Quetzal, the largest port in the country found on the Pacific Ocean and one of the stops of your MSC World Cruise. In the heart of the Mayan culture in Central America, you will begin an adventure that will combine the beauty of an artistic heritage with natural splendors, the discovery of ancient civilizations and the ruins of a still alive and vivacious people, such as can be found at the impressive ruins of Tikal, the largest of the ancient Mayan cities. The Mayan culture survives in the clothes of the people, religious processions, markets and sawdust and petal carpets, a symbol of Guatemalan sacredness. All of this can be found surrounded by an unspoiled habitat, one of the highest volcanoes in the region and what is considered to be one of the most beautiful lakes in the world. Your MSC cruise will take you along the enchanting shores of Lake Atitlan, formed 84,000 years ago in the highlands of Guatemala. Surrounded by many villages, where the inhabitants still wear Mayan traditional dress, the Atitlan boasts immense crops of coffee, avocado groves and a wide variety of agricultural crops along its shores. From Puerto Quetzal, you can easily reach another stop on your holiday: Antigua, a beautiful colonial city located in the center of the country. Famous for its examples of well-preserved Hispano-American Baroque architecture, the city was declared a World Heritage Site by UNESCO in 1979. With MSC Cruises, you can experience the lifestyle of Guatemala and its ancient evocative traditions, changing it from a dream into reality. Go to Puerto Quetzal Cruises visiting Puerto Quetzal

Puerto Quetzal photo — Day 8 May 31, 2027 Puerto Quetzal 09:30 – 20:00 10.5 hrs ashore A voyage between fire and water, between majestic volcanoes and stunning lakes. There are so many colors, you can get lost in them, from the bright traditional clothes of the people to the church facades. Everything is a rainbow of life in Guatemala, starting from Puerto Quetzal, the largest port in the country found on the Pacific Ocean and one of the stops of your MSC World Cruise. In the heart of the Mayan culture in Central America, you will begin an adventure that will combine the beauty of an artistic heritage with natural splendors, the discovery of ancient civilizations and the ruins of a still alive and vivacious people, such as can be found at the impressive ruins of Tikal, the largest of the ancient Mayan cities. The Mayan culture survives in the clothes of the people, religious processions, markets and sawdust and petal carpets, a symbol of Guatemalan sacredness. All of this can be found surrounded by an unspoiled habitat, one of the highest volcanoes in the region and what is considered to be one of the most beautiful lakes in the world. Your MSC cruise will take you along the enchanting shores of Lake Atitlan, formed 84,000 years ago in the highlands of Guatemala. Surrounded by many villages, where the inhabitants still wear Mayan traditional dress, the Atitlan boasts immense crops of coffee, avocado groves and a wide variety of agricultural crops along its shores. From Puerto Quetzal, you can easily reach another stop on your holiday: Antigua, a beautiful colonial city located in the center of the country. Famous for its examples of well-preserved Hispano-American Baroque architecture, the city was declared a World Heritage Site by UNESCO in 1979. With MSC Cruises, you can experience the lifestyle of Guatemala and its ancient evocative traditions, changing it from a dream into reality. Go to Puerto Quetzal Cruises visiting Puerto Quetzal

Day 9 Jun 1, 2027 Acajutla, El Salvador 08:00 – 18:00 10.0 hrs ashore Located in southwest El Salvador, the Pacific coast town of Acajutla was founded in 1524 and is the country’s primary seaport. It’s also a gateway to canopy tours of the Apaneca forests, day trips to the Izalco Volcano and beautiful beaches like Los Cabanos, which is popular amongst surfers and divers. Follow the Route of the Flowers, which winds its way through picturesque small towns, and celebrates cultural events and cuisine, or visit Chalchuapa, home to the pre-Colombian archeological site of Tazumal. These Mayan ruins are believed to date back to AD 100, and are considered the best preserved in all of El Salvador. Go to Acajutla, El Salvador Cruises visiting Acajutla, El Salvador

Day 11 Jun 3, 2027 Puntarenas, Costa Rica 08:00 – 21:00 13.0 hrs ashore The Pearl of the Pacific Ocean On a fine sandy peninsula, 8 km long and an average width of 400 meters, Puntarenas, the "Pearl of the Pacific" can be found. During your MSC World Cruise, you will have the opportunity to visit this city, formerly the largest port in the country and now a busy place full of life, characterized by beautiful beaches and lush nature. One of the best excursions during your holiday in this land will be the Rainforest Skywalk, a combination of suspension bridges and trails through the rain forest to get you acquainted with one of the most complex ecosystems in the world made up of numerous native plant and animal species that can be observed directly in their natural habitat. Puntarenas is also famous for another treasure: its coffee, known as "Grano de Oro". It is not only among the best and most appreciated across the planet, but it has played a key role in the development of Costa Rica, affecting social institutions, culture and politics in the country. Thanks to your MSC Cruise, you will have the chance to taste exceptional coffee in its land of origin, where its roots can be found in the late 1700s in this fertile land with a cool climate, and which even today is one of the main agricultural exports of the country . Our cruise ship will also lead you on the discovery of San José, the capital city which is 115 km from Puntarenas. It is a must-see for its natural beauty, museums, historical sites and its characteristic streets markets. On its streets, you will find a cosmopolitan culture but one that is at the same time very close to roots. Surrounded by mountains and full of rivers and streams, San José is the icing on the cake of your vacation with MSC Cruises. Go to Puntarenas, Costa Rica Cruises visiting Puntarenas, Costa Rica

Puntarenas, Costa Rica photo — Day 11 Jun 3, 2027 Puntarenas, Costa Rica 08:00 – 21:00 13.0 hrs ashore The Pearl of the Pacific Ocean On a fine sandy peninsula, 8 km long and an average width of 400 meters, Puntarenas, the "Pearl of the Pacific" can be found. During your MSC World Cruise, you will have the opportunity to visit this city, formerly the largest port in the country and now a busy place full of life, characterized by beautiful beaches and lush nature. One of the best excursions during your holiday in this land will be the Rainforest Skywalk, a combination of suspension bridges and trails through the rain forest to get you acquainted with one of the most complex ecosystems in the world made up of numerous native plant and animal species that can be observed directly in their natural habitat. Puntarenas is also famous for another treasure: its coffee, known as "Grano de Oro". It is not only among the best and most appreciated across the planet, but it has played a key role in the development of Costa Rica, affecting social institutions, culture and politics in the country. Thanks to your MSC Cruise, you will have the chance to taste exceptional coffee in its land of origin, where its roots can be found in the late 1700s in this fertile land with a cool climate, and which even today is one of the main agricultural exports of the country . Our cruise ship will also lead you on the discovery of San José, the capital city which is 115 km from Puntarenas. It is a must-see for its natural beauty, museums, historical sites and its characteristic streets markets. On its streets, you will find a cosmopolitan culture but one that is at the same time very close to roots. Surrounded by mountains and full of rivers and streams, San José is the icing on the cake of your vacation with MSC Cruises. Go to Puntarenas, Costa Rica Cruises visiting Puntarenas, Costa Rica

Day 14 Jun 6, 2027 Cartagena, Colombia Arrives 13:30 Cobbled streets, balconies overflowing with blooming bougainvillea and pastel-coloured buildings lining elegant plazas make Cartagena in Colombia one of the Caribbean's most photogenic cities, and a memorable stop on an MSC Caribbean and Antilles cruise. Founded in 1533, this Spanish colonial city, a UNESCO World Heritage Site, is steeped in history. Its location made it a popular target for plunderers and English pirates, and arguably features the most impressive collection of forts in the Caribbean. Today the city is eager to share its treasures with modern visitors. Magnificent colonial structures such as the 16th-century Santa Catalina Cathedral, with its striking stuccoes and dome tower, and the three-arch clock gate, the Torre del Reloj, are just two of the many landmarks of this enchanting city dotted with many squares and sidewalk cafés. A wonderful photo stop on our Cartagena City MSC excursion is the San Felipe de Barajas fortress, a marvel of colonial Spanish military engineering. Its construction began in 1536. Slaves la-boured for more than 120 years to erect this fortress - built on high ground with dominating ap-proaches to the city by land and sea to fend off pirates - and its network of tunnels. On yet another MSC excursion, enrich your palate as you learn about the rich aromas and flavours of Colombian coffee. Introduced by the Jesuits in 1723, coffee quickly became a key crop in Colombia, which is now one of the top producers of Arabica coffee in the world. Colombia is also the world’s top producer of emeralds. If jewellery and gems fascinate you, learn all about these green precious stones and make your own emerald-studded jewellery in sterling silver during a hands-on MSC excursion that guides you step-by-step. And you don’t need to go far to explore nature. An MSC excursion takes you by canoe through mangrove tunnels to Ciénaga de la Virgen, where you can witness a diversity of birds from king-fishers and white herons to pelicans and pink-feathered roseate spoonbills. Go to Cartagena, Colombia Cruises visiting Cartagena, Colombia

Cartagena, Colombia photo — Day 14 Jun 6, 2027 Cartagena, Colombia Arrives 13:30 Cobbled streets, balconies overflowing with blooming bougainvillea and pastel-coloured buildings lining elegant plazas make Cartagena in Colombia one of the Caribbean's most photogenic cities, and a memorable stop on an MSC Caribbean and Antilles cruise. Founded in 1533, this Spanish colonial city, a UNESCO World Heritage Site, is steeped in history. Its location made it a popular target for plunderers and English pirates, and arguably features the most impressive collection of forts in the Caribbean. Today the city is eager to share its treasures with modern visitors. Magnificent colonial structures such as the 16th-century Santa Catalina Cathedral, with its striking stuccoes and dome tower, and the three-arch clock gate, the Torre del Reloj, are just two of the many landmarks of this enchanting city dotted with many squares and sidewalk cafés. A wonderful photo stop on our Cartagena City MSC excursion is the San Felipe de Barajas fortress, a marvel of colonial Spanish military engineering. Its construction began in 1536. Slaves la-boured for more than 120 years to erect this fortress - built on high ground with dominating ap-proaches to the city by land and sea to fend off pirates - and its network of tunnels. On yet another MSC excursion, enrich your palate as you learn about the rich aromas and flavours of Colombian coffee. Introduced by the Jesuits in 1723, coffee quickly became a key crop in Colombia, which is now one of the top producers of Arabica coffee in the world. Colombia is also the world’s top producer of emeralds. If jewellery and gems fascinate you, learn all about these green precious stones and make your own emerald-studded jewellery in sterling silver during a hands-on MSC excursion that guides you step-by-step. And you don’t need to go far to explore nature. An MSC excursion takes you by canoe through mangrove tunnels to Ciénaga de la Virgen, where you can witness a diversity of birds from king-fishers and white herons to pelicans and pink-feathered roseate spoonbills. Go to Cartagena, Colombia Cruises visiting Cartagena, Colombia

Day 18 Jun 10, 2027 Miami, Florida Arrives 06:30 Miami is called the gateway to the Americas, and it’s indeed a very glamourous global city to explore at the start or end of an MSC Caribbean and Antilles cruise. Home to many cultures, the city of Miami sizzles with flavours from the Americas, beginning with Cuba and the Little Havana neighbourhood - one of the most historically significant places, while Wynwood is famous for its wall art and Puerto Rican history. Across Biscayne Bay lies the city of Miami Beach, home to the world-famous South Beach. An MSC-arranged guided private tour opens up a world of possibilities for you: enjoy the beach, take in the city’s Art Deco architecture and enjoy a drink on legendary Ocean Drive, where you can people watch, and perhaps spot a celebrity. If time permits, take a stroll on artsy Lincoln Road packed with street side cafes and shops. Facing the MSC Cruises port in downtown Miami is Bayside Marketplace - a lively commercial centre that is a staging area for boat tours of Miami. Seeing the city from the water, with its impressive skyline and waterfront mansions, is an experience in itself. The downtown area also boasts the dazzling Performing Arts Centre, the Museum of Science, the Pérez Art Museum Miami (known as the PAMM), scenic Bayfront Park and the arena where the 3-time NBA champion Miami Heat basketball team plays. Miami is renowned for its shopping. Hop on a tour to see the major city sights followed by retail therapy at one of Miami's largest and newest shopping malls: Dolphin Mall. With more than 240 retail outlets, you’re bound to need a bit of room in your luggage for your purchases. Luckily, there are several luggage stores at the mall to fill that need. Head west past the city into untamed wilderness on an MSC excursion into the Everglades. At this national park where water is the central feature, unlike any other in North America, nature enthusiasts can hop on an airboat tour through the swampland and waterways to spot alligators and a variety of birds. Go to Miami, Florida Cruises visiting Miami, Florida

Miami, Florida photo — Day 18 Jun 10, 2027 Miami, Florida Arrives 06:30 Miami is called the gateway to the Americas, and it’s indeed a very glamourous global city to explore at the start or end of an MSC Caribbean and Antilles cruise. Home to many cultures, the city of Miami sizzles with flavours from the Americas, beginning with Cuba and the Little Havana neighbourhood - one of the most historically significant places, while Wynwood is famous for its wall art and Puerto Rican history. Across Biscayne Bay lies the city of Miami Beach, home to the world-famous South Beach. An MSC-arranged guided private tour opens up a world of possibilities for you: enjoy the beach, take in the city’s Art Deco architecture and enjoy a drink on legendary Ocean Drive, where you can people watch, and perhaps spot a celebrity. If time permits, take a stroll on artsy Lincoln Road packed with street side cafes and shops. Facing the MSC Cruises port in downtown Miami is Bayside Marketplace - a lively commercial centre that is a staging area for boat tours of Miami. Seeing the city from the water, with its impressive skyline and waterfront mansions, is an experience in itself. The downtown area also boasts the dazzling Performing Arts Centre, the Museum of Science, the Pérez Art Museum Miami (known as the PAMM), scenic Bayfront Park and the arena where the 3-time NBA champion Miami Heat basketball team plays. Miami is renowned for its shopping. Hop on a tour to see the major city sights followed by retail therapy at one of Miami's largest and newest shopping malls: Dolphin Mall. With more than 240 retail outlets, you’re bound to need a bit of room in your luggage for your purchases. Luckily, there are several luggage stores at the mall to fill that need. Head west past the city into untamed wilderness on an MSC excursion into the Everglades. At this national park where water is the central feature, unlike any other in North America, nature enthusiasts can hop on an airboat tour through the swampland and waterways to spot alligators and a variety of birds. Go to Miami, Florida Cruises visiting Miami, Florida

Pricing

Lowest fare we've tracked over the observed 88-day span: $4,459 · range $4,459–$6,129

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $5,779

$339 / night

Fare rows

Club Interior Stateroom

Cabin grade

Available

from $5,779

$339 / night

per person · incl. taxes

Club Interior Stateroom

Cabin grade

Available

from $6,099

$358 / night

per person · incl. taxes

Club Interior Stateroom

Cabin grade

Available

from $6,209

$365 / night

per person · incl. taxes

Oceanview

from $6,239

$367 / night

Fare rows

Club Oceanview Stateroom (Obstructed View)

Cabin grade

Available

from $6,239

$367 / night

per person · incl. taxes

Club Oceanview Stateroom

Cabin grade

Available

from $6,399

$376 / night

per person · incl. taxes

Club Oceanview Stateroom

Cabin grade

Available

from $6,559

$385 / night

per person · incl. taxes

Club Oceanview Stateroom

Cabin grade

Available

from $6,719

$395 / night

per person · incl. taxes

Balcony

from $7,079

$416 / night

Fare rows

Club Veranda Stateroom

Cabin grade

Available

from $7,079

$416 / night

per person · incl. taxes

Club Veranda Stateroom

Cabin grade

Available

from $7,169

$421 / night

per person · incl. taxes

Club Veranda Stateroom

Cabin grade

Available

from $7,259

$427 / night

per person · incl. taxes

Club Veranda Plus Stateroom

Cabin grade

Available

from $7,619

$448 / night

per person · incl. taxes

Club Veranda Plus Stateroom

Cabin grade

Available

from $7,709

$453 / night

per person · incl. taxes

Club Veranda Plus Stateroom

Cabin grade

Available

from $7,799

$458 / night

per person · incl. taxes

Suite

from $11,669

$686 / night

Fare rows

Club Continent Suite

Cabin grade

Available

from $11,669

$686 / night

per person · incl. taxes

Club Continent Suite

Cabin grade

Available

from $11,959

$703 / night

per person · incl. taxes

Grandview Suite Stateroom

Cabin grade

Available

from $13,069

$768 / night

per person · incl. taxes

Club Spa Suite

Cabin grade

Available

from $16,229

$954 / night

per person · incl. taxes

Club Ocean Suite

Cabin grade

Available

from $17,909

$1,053 / night

per person · incl. taxes

Club World Owners Suite

Cabin grade

Available

from $19,899

$1,170 / night

per person · incl. taxes

Prices verified Jun 21, 2026

Prices come from third-party data feeds via Azamara and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

All cabin grades (27) Detailed cabin specs available at booking.

Name	Supplier code	Type
Not listed
Club Veranda Plus Stateroom	P1	Balcony
Club Veranda Plus Stateroom	P2	Balcony
Club Veranda Plus Stateroom	P3	Balcony
Club Veranda Stateroom	V1	Balcony
Club Veranda Stateroom	V2	Balcony
Club Veranda Stateroom	V3	Balcony
Club Veranda Stateroom - Guaranteed	X	Balcony
Club Veranda Plus Stateroom - Guaranteed	XP	Balcony
Club Interior Stateroom	09	Inside
Club Interior Stateroom	10	Inside
Club Interior Stateroom	11	Inside
Club Interior Stateroom	12	Inside
Interior Stateroom - Guaranteed	Z	Inside
Club Oceanview Stateroom	04	Oceanview
Club Oceanview Stateroom	05	Oceanview
Club Oceanview Stateroom	06	Oceanview
Club Oceanview Stateroom (Obstructed View)	08	Oceanview
Oceanview Stateroom - Guaranteed	Y	Oceanview
Club Ocean Suite	CO	Suite
Panorama Suite Stateroom	CS	Suite
Club World Owners Suite	CW	Suite
Grandview Suite Stateroom	E1	Suite
Club Continent Suite	N1	Suite
Club Continent Suite	N2	Suite
Club Spa Suite	SP	Suite
Suite - Guaranteed	W	Suite