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16-night Panama Canal cruise: Miami, Florida to Los Angeles, CA on Seven Seas Prestige

The Miami to Los Angeles is a 16-night Panama Canal cruise aboard Seven Seas Prestige, operated by Regent Seven Seas Cruises. Departing Miami, Florida on February 7, 2029 and arriving in Los Angeles, CA on February 23, 2029, the voyage visits 9 ports including George Town, Cayman Islands, Cartagena, Colombia, Puntarenas, Costa Rica. Fares start from $11,899 per person.

Length
16 nights
Departs
Feb 7, 2029
Returns
Feb 23, 2029
Ports of call
9
Days at sea
8

Voyage code PRT290207

Miami, Florida

16 nights · Panama Canal

from $11,899 pp

via CruiseDirect

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Why this route stands out

A closer look at the journey

Miami, Florida

Miami is called the gateway to the Americas, and it’s indeed a very glamourous global city to explore at the start or end of an MSC Caribbean and Antilles cruise. Home to many cultures, the city of Miami sizzles with flavours from the Americas, beginning with Cuba and the Little Havana neighbourhood - one of the most historically significant places, while Wynwood is famous for its wall art and Puerto Rican history. Across Biscayne Bay lies the city of Miami Beach, home to the world-famous South Beach. An MSC-arranged guided private tour opens up a world of possibilities for you: enjoy the beach, take in the city’s Art Deco architecture and enjoy a drink on legendary Ocean Drive, where you can people watch, and perhaps spot a celebrity. If time permits, take a stroll on artsy Lincoln Road packed with street side cafes and shops. Facing the MSC Cruises port in downtown Miami is Bayside Marketplace - a lively commercial centre that is a staging area for boat tours of Miami. Seeing the city from the water, with its impressive skyline and waterfront mansions, is an experience in itself. The downtown area also boasts the dazzling Performing Arts Centre, the Museum of Science, the Pérez Art Museum Miami (known as the PAMM), scenic Bayfront Park and the arena where the 3-time NBA champion Miami Heat basketball team plays. Miami is renowned for its shopping. Hop on a tour to see the major city sights followed by retail therapy at one of Miami's largest and newest shopping malls: Dolphin Mall. With more than 240 retail outlets, you’re bound to need a bit of room in your luggage for your purchases. Luckily, there are several luggage stores at the mall to fill that need. Head west past the city into untamed wilderness on an MSC excursion into the Everglades. At this national park where water is the central feature, unlike any other in North America, nature enthusiasts can hop on an airboat tour through the swampland and waterways to spot alligators and a variety of birds.

George Town, Cayman Islands

Christopher Columbus called the Cayman Islands, with their tranquil blue waters, "Las Tortugas" for its abundance of turtles. Located between Cuba and Jamaica, the Cayman Islands are comprised of three Caribbean islands: Grand Cayman, Little Cayman and Cayman Brac. Beautiful landscapes, bountiful wildlife and colourful streets embody this British Overseas Territory, with George Town, its capital, located on Grand Cayman, the largest and most populous island. When you arrive in George Town on an MSC Caribbean and Antilles cruise, you’ll discover that wildlife conservation is at the core of Grand Cayman’s offerings. For the chance of a lifetime to swim, feed and interact with stingrays, book an MSC excursion to Stingray City, where you’ll get an up-close experience with Cayman’s most graceful marine creatures. On yet another MSC excursion to the Cayman Turtle Centre, encounter the green turtles that return each and every year to lay their eggs on one of the beaches, visit the turtle hatchery, snorkel alongside yearlings in the Turtle Lagoon and meet the island’s endangered blue iguanas. For a special experience, ride horses bareback into the Caribbean Sea at Barker’s National Park on an exclusive Martha Stewart excursion curated just for MSC Cruises, followed by lunch at Vivo café, a spot beloved for its mostly vegan cuisine, with organic ingredients sourced straight from local farms. To learn about Cayman’s past and culture, explore Cayman Heritage House and visit the sumptuous Government House, the governor's residence built in 1964 located in front of Seven Mile Beach, one of the most prestigious beaches of Grand Cayman, in the heart of West Bay. Shopaholics will also delight in this destination. The Cayman Islands are entirely duty free. You just have to choose what catches your fancy among the myriad of watches, liqueurs, jewellery and porcelain on offer.

Cartagena, Colombia

Cobbled streets, balconies overflowing with blooming bougainvillea and pastel-coloured buildings lining elegant plazas make Cartagena in Colombia one of the Caribbean's most photogenic cities, and a memorable stop on an MSC Caribbean and Antilles cruise. Founded in 1533, this Spanish colonial city, a UNESCO World Heritage Site, is steeped in history. Its location made it a popular target for plunderers and English pirates, and arguably features the most impressive collection of forts in the Caribbean. Today the city is eager to share its treasures with modern visitors. Magnificent colonial structures such as the 16th-century Santa Catalina Cathedral, with its striking stuccoes and dome tower, and the three-arch clock gate, the Torre del Reloj, are just two of the many landmarks of this enchanting city dotted with many squares and sidewalk cafés. A wonderful photo stop on our Cartagena City MSC excursion is the San Felipe de Barajas fortress, a marvel of colonial Spanish military engineering. Its construction began in 1536. Slaves la-boured for more than 120 years to erect this fortress - built on high ground with dominating ap-proaches to the city by land and sea to fend off pirates - and its network of tunnels. On yet another MSC excursion, enrich your palate as you learn about the rich aromas and flavours of Colombian coffee. Introduced by the Jesuits in 1723, coffee quickly became a key crop in Colombia, which is now one of the top producers of Arabica coffee in the world. Colombia is also the world’s top producer of emeralds. If jewellery and gems fascinate you, learn all about these green precious stones and make your own emerald-studded jewellery in sterling silver during a hands-on MSC excursion that guides you step-by-step. And you don’t need to go far to explore nature. An MSC excursion takes you by canoe through mangrove tunnels to Ciénaga de la Virgen, where you can witness a diversity of birds from king-fishers and white herons to pelicans and pink-feathered roseate spoonbills.

Price tracking

Today’s fare, in context

Price history

30 days
Fare details

Fare details

Per person · taxes & fees included
Current fares
Verified 18 hours ago
Suite
$11,899
Tracked range
105 days
Price history by cabin type
CabinCurrentLowestHighest
Suite $11,899 $11,899 on May 20 $11,899 on May 20
Cabin grades
20 total
Penthouse SuiteSuite · A
Penthouse SuiteSuite · B
Penthouse SuiteSuite · C
Concierge SuiteSuite · D
Concierge SuiteSuite · E
Serenity SuiteSuite · F1
Serenity SuiteSuite · F2
Deluxe Veranda SuiteSuite · G
Grand SuiteSuite · GS
Deluxe Veranda SuiteSuite · H
Horizon Penthouse SuiteSuite · HP
SuiteSuite · I
Grand Loft SuiteSuite · LS
Prestige SuiteSuite · PS
Skyview Regent SuiteSuite · RS
Signature SuiteSuite · SG
Skyview Aura SuiteSuite · SKA
Skyview Luna SuiteSuite · SKB
Skyview Sola SuiteSuite · SKC
Seven Seas SuiteSuite · SS

○ = last seen (sold out or delisted). · Verified 18 hours ago.

Lowest fares with no residency, age, or service requirement — verify eligibility at booking. How our pricing works

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

Not available

Oceanview

Not available

Balcony

Not available

Suite

from $11,899

$743 / night

Fare rows

Deluxe Veranda Suite

Cabin grade

Available

from $11,899

$743 / night

per person · incl. taxes & fees

Deluxe Veranda Suite

Cabin grade

Available

from $12,199

$762 / night

per person · incl. taxes & fees

Serenity Suite

Cabin grade

Available

from $12,499

$781 / night

per person · incl. taxes & fees

Serenity Suite

Cabin grade

Available

from $12,799

$799 / night

per person · incl. taxes & fees

Concierge Suite

Cabin grade

Available

from $13,069

$816 / night

per person · incl. taxes & fees

Concierge Suite

Cabin grade

Available

from $13,369

$835 / night

per person · incl. taxes & fees

Deluxe Veranda Suite

Cabin grade

Available

from $15,399

$962 / night

per person · incl. taxes & fees

Deluxe Veranda Suite

Cabin grade

Available

from $15,699

$981 / night

per person · incl. taxes & fees

Serenity Suite

Cabin grade

Available

from $15,999

$999 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $16,069

$1,004 / night

per person · incl. taxes & fees

Serenity Suite

Cabin grade

Available

from $16,299

$1,018 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $16,469

$1,029 / night

per person · incl. taxes & fees

Concierge Suite

Cabin grade

Available

from $16,799

$1,049 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $16,869

$1,054 / night

per person · incl. taxes & fees

Concierge Suite

Cabin grade

Available

from $17,099

$1,068 / night

per person · incl. taxes & fees

Horizon Penthouse Suite

Cabin grade

Available

from $18,169

$1,135 / night

per person · incl. taxes & fees

Seven Seas Suite

Cabin grade

Available

from $19,769

$1,235 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $19,799

$1,237 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $20,199

$1,262 / night

per person · incl. taxes & fees

Penthouse Suite

Cabin grade

Available

from $20,599

$1,287 / night

per person · incl. taxes & fees

Prestige Suite

Cabin grade

Available

from $21,769

$1,360 / night

per person · incl. taxes & fees

Horizon Penthouse Suite

Cabin grade

Available

from $21,899

$1,368 / night

per person · incl. taxes & fees

Seven Seas Suite

Cabin grade

Available

from $23,499

$1,468 / night

per person · incl. taxes & fees

Grand Suite

Cabin grade

Available

from $24,569

$1,535 / night

per person · incl. taxes & fees

Prestige Suite

Cabin grade

Available

from $25,499

$1,593 / night

per person · incl. taxes & fees

Grand Loft Suite

Cabin grade

Available

from $26,069

$1,629 / night

per person · incl. taxes & fees

Grand Suite

Cabin grade

Available

from $28,299

$1,768 / night

per person · incl. taxes & fees

Grand Loft Suite

Cabin grade

Available

from $29,799

$1,862 / night

per person · incl. taxes & fees

Signature Suite

Cabin grade

Available

from $38,369

$2,398 / night

per person · incl. taxes & fees

Signature Suite

Cabin grade

Available

from $42,099

$2,631 / night

per person · incl. taxes & fees

Skyview Sola Suite

Cabin grade

Available

from $42,369

$2,648 / night

per person · incl. taxes & fees

Skyview Luna Suite

Cabin grade

Available

from $45,569

$2,848 / night

per person · incl. taxes & fees

Skyview Sola Suite

Cabin grade

Available

from $46,099

$2,881 / night

per person · incl. taxes & fees

Skyview Aura Suite

Cabin grade

Available

from $48,769

$3,048 / night

per person · incl. taxes & fees

Skyview Luna Suite

Cabin grade

Available

from $49,299

$3,081 / night

per person · incl. taxes & fees

Skyview Aura Suite

Cabin grade

Available

from $52,499

$3,281 / night

per person · incl. taxes & fees

Skyview Regent Suite

Cabin grade

Available

from $199,769

$12,485 / night

per person · incl. taxes & fees

Skyview Regent Suite

Cabin grade

Available

from $203,499

$12,718 / night

per person · incl. taxes & fees

Prices verified Aug 31, 2026

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The journey

16 nights, in order

Miami, Florida

Day 1 Feb 7, 2029

Miami, Florida

Miami is called the gateway to the Americas, and it’s indeed a very glamourous global city to explore at the start or end of an MSC Caribbean and Antilles cruise.

Explore Miami, Florida

Day by day

The full itinerary

17 scheduled calls
Seven Seas Prestige

Your ship

Seven Seas Prestige

Seven Seas Prestige will be the first of two Prestige-Class ships, the second of which will be launched in 2029. The new ship class will introduce brand new accommodation categories, including a reimagination of the palatial Regent Suite, plus new dining experiences, all of which will be revealed at a later date. These new features will further enhance The Most Inclusive Luxury Experience® that Regent is known for with inclusions such as flights and transfers, gourmet cuisine in a range of specialty restaurants and al-fresco dining venues, fine wines and spirits, entertainment, unlimited internet access, free valet laundry, gratuities, one-night, pre-cruise hotel packages for guests staying in Concierge-level suites and higher and more.

6★ 77,000 GT 850 Passengers
Seven Seas Prestige ship guide Search cruises on Seven Seas Prestige

Deck plans

Deck plan for Deck 4

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from $11,899 pp

via CruiseDirect

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