15 Night Panama Canal Eastward Cruise

15 nights Oct 7, 2027

The 15 Night Panama Canal Eastward Cruise is a 15-night Caribbean cruise aboard Serenade of the Seas, operated by Royal Caribbean. Departing San Diego, California on October 7, 2027, the voyage visits 8 ports. Fares start from $1,986 per person.

from $1,986

$132 / night per person, incl. taxes & fees

See prices

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from $1,986 pp

Continues on Royal Caribbean's site

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Itinerary

Day 1 Oct 7, 2027 San Diego, California Departs 17:00 Free from smog and jungle-like freeways, San Diego sits gracefully around a beautiful curving bay. Although affluent and conservative, this second largest city in California is also amiable and easygoing. San Diego has a vibrant and active downtown area, and since the late 1970s several blocks of early 20th century architecture have been stylishly renovated, while the sleek modern bank buildings symbolize the city's growing economic significance on the Pacific Rim. San Diego is the birthplace of California. Portuguese explorer Juan Rodrigues Cabrillo landed here in 1542; since then, San Diego has been under Spanish, Mexican and after 1846, American rule. The city really took off with the arrival of the Santa Fe Railroad in the 1880s, but in terms of trade and significance it has long played second fiddle to Los Angeles. However, during World War II the U.S. Navy made San Diego their Pacific Command Center and the military continue to dominate the local economy, along now with tourism. Within easy reach of the downtown area, encompassing 1,400 acres of cultural, recreational and environmental delights, San Diego's Balboa Park is a sumptuous place with trees, gardens, traffic-free promenades and a large concentration of Spanish-colonial style buildings. The Hillcrest area is the lively and artsy center of the city, and Old Town San Diego is now a historical park where the city's Spanish and Mexican history and heritage are most evident. The Gaslamp Quarter, once the heart of frontier San Diego, is today filled with smart streets lined with chic cafés, antique stores, art galleries and gas lamps (powered by electricity). Most of the eastern part of the county is taken up by the 600,000-acre Anza-Borrego Desert. Another must-see is the city's most famous attraction, the San Diego Zoo. Go to San Diego, California Cruises visiting San Diego, California

Day 4 Oct 10, 2027 Puerto Vallarta, Mexico 08:00 – 17:00 9.0 hrs ashore Located in the center of Mexico's Pacific coast, Puerto Vallarta is one of the country's most picturesque cities and holiday destinations. Its cobblestone streets and red-roofed, white adobe-style buildings nestle between palm-covered mountains and the vast Banderas Bay. Stretches of white sand beaches are among the best in Mexico and the climate is consistently warm and sunny. For years, vacationers who had discovered the beauty of Puerto Vallarta tried to keep the "good news" from spreading. The arrival of a major film company and two of the world's best-known stars, Elizabeth Taylor and Richard Burton, changed Puerto Vallarta from a laid-back town to a famous getaway destination almost overnight. In addition to its visual appeal, Puerto Vallarta offers a variety of cultural entertainment and a lively nightlife. Take time to see the sights of the city. Downtown spreads around the small Isla Cuale, which lies in the middle of the Cuale River; the heart of the city is a few blocks north around the Municipal Square. A crown-topped cathedral, dedicated to the Virgin of Guadalupe, rises behind the square; a wide seaside promenade, known as the Malecon, hugs the oceanfront. A seahorse statue welcomes visitors to the downtown beach area. The statue and the prominent church tower have become symbols of Puerto Vallarta, or PV as locals call their town for short. Puerto Vallarta grew from an existing fishing village with a history dating back some 100 years. Because of its veritable heritage as a Mexican pueblo, the town tends to offer more of the country's artistic and cultural tradition than other Mexican resorts. The origin of the charro (traditional costume), the national beverage tequila and the typical music of the mariachi bands are credited to Puerto Vallarta. It is considered the most Mexican of all the country's resort towns. Go to Puerto Vallarta, Mexico Cruises visiting Puerto Vallarta, Mexico

Puerto Vallarta, Mexico photo — Day 4 Oct 10, 2027 Puerto Vallarta, Mexico 08:00 – 17:00 9.0 hrs ashore Located in the center of Mexico's Pacific coast, Puerto Vallarta is one of the country's most picturesque cities and holiday destinations. Its cobblestone streets and red-roofed, white adobe-style buildings nestle between palm-covered mountains and the vast Banderas Bay. Stretches of white sand beaches are among the best in Mexico and the climate is consistently warm and sunny. For years, vacationers who had discovered the beauty of Puerto Vallarta tried to keep the "good news" from spreading. The arrival of a major film company and two of the world's best-known stars, Elizabeth Taylor and Richard Burton, changed Puerto Vallarta from a laid-back town to a famous getaway destination almost overnight. In addition to its visual appeal, Puerto Vallarta offers a variety of cultural entertainment and a lively nightlife. Take time to see the sights of the city. Downtown spreads around the small Isla Cuale, which lies in the middle of the Cuale River; the heart of the city is a few blocks north around the Municipal Square. A crown-topped cathedral, dedicated to the Virgin of Guadalupe, rises behind the square; a wide seaside promenade, known as the Malecon, hugs the oceanfront. A seahorse statue welcomes visitors to the downtown beach area. The statue and the prominent church tower have become symbols of Puerto Vallarta, or PV as locals call their town for short. Puerto Vallarta grew from an existing fishing village with a history dating back some 100 years. Because of its veritable heritage as a Mexican pueblo, the town tends to offer more of the country's artistic and cultural tradition than other Mexican resorts. The origin of the charro (traditional costume), the national beverage tequila and the typical music of the mariachi bands are credited to Puerto Vallarta. It is considered the most Mexican of all the country's resort towns. Go to Puerto Vallarta, Mexico Cruises visiting Puerto Vallarta, Mexico

Day 7 Oct 13, 2027 Puerto Quetzal 08:00 – 17:00 9.0 hrs ashore A voyage between fire and water, between majestic volcanoes and stunning lakes. There are so many colors, you can get lost in them, from the bright traditional clothes of the people to the church facades. Everything is a rainbow of life in Guatemala, starting from Puerto Quetzal, the largest port in the country found on the Pacific Ocean and one of the stops of your MSC World Cruise. In the heart of the Mayan culture in Central America, you will begin an adventure that will combine the beauty of an artistic heritage with natural splendors, the discovery of ancient civilizations and the ruins of a still alive and vivacious people, such as can be found at the impressive ruins of Tikal, the largest of the ancient Mayan cities. The Mayan culture survives in the clothes of the people, religious processions, markets and sawdust and petal carpets, a symbol of Guatemalan sacredness. All of this can be found surrounded by an unspoiled habitat, one of the highest volcanoes in the region and what is considered to be one of the most beautiful lakes in the world. Your MSC cruise will take you along the enchanting shores of Lake Atitlan, formed 84,000 years ago in the highlands of Guatemala. Surrounded by many villages, where the inhabitants still wear Mayan traditional dress, the Atitlan boasts immense crops of coffee, avocado groves and a wide variety of agricultural crops along its shores. From Puerto Quetzal, you can easily reach another stop on your holiday: Antigua, a beautiful colonial city located in the center of the country. Famous for its examples of well-preserved Hispano-American Baroque architecture, the city was declared a World Heritage Site by UNESCO in 1979. With MSC Cruises, you can experience the lifestyle of Guatemala and its ancient evocative traditions, changing it from a dream into reality. Go to Puerto Quetzal Cruises visiting Puerto Quetzal

Puerto Quetzal photo — Day 7 Oct 13, 2027 Puerto Quetzal 08:00 – 17:00 9.0 hrs ashore A voyage between fire and water, between majestic volcanoes and stunning lakes. There are so many colors, you can get lost in them, from the bright traditional clothes of the people to the church facades. Everything is a rainbow of life in Guatemala, starting from Puerto Quetzal, the largest port in the country found on the Pacific Ocean and one of the stops of your MSC World Cruise. In the heart of the Mayan culture in Central America, you will begin an adventure that will combine the beauty of an artistic heritage with natural splendors, the discovery of ancient civilizations and the ruins of a still alive and vivacious people, such as can be found at the impressive ruins of Tikal, the largest of the ancient Mayan cities. The Mayan culture survives in the clothes of the people, religious processions, markets and sawdust and petal carpets, a symbol of Guatemalan sacredness. All of this can be found surrounded by an unspoiled habitat, one of the highest volcanoes in the region and what is considered to be one of the most beautiful lakes in the world. Your MSC cruise will take you along the enchanting shores of Lake Atitlan, formed 84,000 years ago in the highlands of Guatemala. Surrounded by many villages, where the inhabitants still wear Mayan traditional dress, the Atitlan boasts immense crops of coffee, avocado groves and a wide variety of agricultural crops along its shores. From Puerto Quetzal, you can easily reach another stop on your holiday: Antigua, a beautiful colonial city located in the center of the country. Famous for its examples of well-preserved Hispano-American Baroque architecture, the city was declared a World Heritage Site by UNESCO in 1979. With MSC Cruises, you can experience the lifestyle of Guatemala and its ancient evocative traditions, changing it from a dream into reality. Go to Puerto Quetzal Cruises visiting Puerto Quetzal

Day 9 Oct 15, 2027 Puntarenas, Costa Rica 08:00 – 17:00 9.0 hrs ashore The Pearl of the Pacific Ocean On a fine sandy peninsula, 8 km long and an average width of 400 meters, Puntarenas, the "Pearl of the Pacific" can be found. During your MSC World Cruise, you will have the opportunity to visit this city, formerly the largest port in the country and now a busy place full of life, characterized by beautiful beaches and lush nature. One of the best excursions during your holiday in this land will be the Rainforest Skywalk, a combination of suspension bridges and trails through the rain forest to get you acquainted with one of the most complex ecosystems in the world made up of numerous native plant and animal species that can be observed directly in their natural habitat. Puntarenas is also famous for another treasure: its coffee, known as "Grano de Oro". It is not only among the best and most appreciated across the planet, but it has played a key role in the development of Costa Rica, affecting social institutions, culture and politics in the country. Thanks to your MSC Cruise, you will have the chance to taste exceptional coffee in its land of origin, where its roots can be found in the late 1700s in this fertile land with a cool climate, and which even today is one of the main agricultural exports of the country . Our cruise ship will also lead you on the discovery of San José, the capital city which is 115 km from Puntarenas. It is a must-see for its natural beauty, museums, historical sites and its characteristic streets markets. On its streets, you will find a cosmopolitan culture but one that is at the same time very close to roots. Surrounded by mountains and full of rivers and streams, San José is the icing on the cake of your vacation with MSC Cruises. Go to Puntarenas, Costa Rica Cruises visiting Puntarenas, Costa Rica

Puntarenas, Costa Rica photo — Day 9 Oct 15, 2027 Puntarenas, Costa Rica 08:00 – 17:00 9.0 hrs ashore The Pearl of the Pacific Ocean On a fine sandy peninsula, 8 km long and an average width of 400 meters, Puntarenas, the "Pearl of the Pacific" can be found. During your MSC World Cruise, you will have the opportunity to visit this city, formerly the largest port in the country and now a busy place full of life, characterized by beautiful beaches and lush nature. One of the best excursions during your holiday in this land will be the Rainforest Skywalk, a combination of suspension bridges and trails through the rain forest to get you acquainted with one of the most complex ecosystems in the world made up of numerous native plant and animal species that can be observed directly in their natural habitat. Puntarenas is also famous for another treasure: its coffee, known as "Grano de Oro". It is not only among the best and most appreciated across the planet, but it has played a key role in the development of Costa Rica, affecting social institutions, culture and politics in the country. Thanks to your MSC Cruise, you will have the chance to taste exceptional coffee in its land of origin, where its roots can be found in the late 1700s in this fertile land with a cool climate, and which even today is one of the main agricultural exports of the country . Our cruise ship will also lead you on the discovery of San José, the capital city which is 115 km from Puntarenas. It is a must-see for its natural beauty, museums, historical sites and its characteristic streets markets. On its streets, you will find a cosmopolitan culture but one that is at the same time very close to roots. Surrounded by mountains and full of rivers and streams, San José is the icing on the cake of your vacation with MSC Cruises. Go to Puntarenas, Costa Rica Cruises visiting Puntarenas, Costa Rica

Day 11 Oct 17, 2027 Panama Canal 06:00 – 18:00 12.0 hrs ashore Panama is synonymous with the Panama Canal. While Panama connects Central America to South America, the Panama Canal, which opened in 1914, connects the Caribbean Sea with the Pacific Ocean. The channel reduces shipping time and currently connects 160 countries and 1,700 ports around the world. Hailed as an engineering marvel, the artificial waterway with its elaborate lock system is one of the greatest achievements of the 20th century. Arriving on an MSC Caribbean and Antilles cruise into Colón, Panama’s gateway city, you’ll encounter the irresistible juxtaposition of the ancient and modern, the artificial and natural, as enormous computerized container ships transiting the canal slice through primeval rainforests teeming with fluorescent frogs and elusive wild cats. Book an MSC excursion to hop on a ferry that will take you along the length of the Panama Canal, through lakes and locks and past the Centennial and Americas bridges. Finally, you will arrive at Pacific port at the entrance to the Panama Canal, and then enjoy a 90-minute bus ride back to your ship. Go to Panama Canal Cruises visiting Panama Canal

Day 12 Oct 18, 2027 Cartagena, Colombia 11:30 – 19:00 7.5 hrs ashore Cobbled streets, balconies overflowing with blooming bougainvillea and pastel-coloured buildings lining elegant plazas make Cartagena in Colombia one of the Caribbean's most photogenic cities, and a memorable stop on an MSC Caribbean and Antilles cruise. Founded in 1533, this Spanish colonial city, a UNESCO World Heritage Site, is steeped in history. Its location made it a popular target for plunderers and English pirates, and arguably features the most impressive collection of forts in the Caribbean. Today the city is eager to share its treasures with modern visitors. Magnificent colonial structures such as the 16th-century Santa Catalina Cathedral, with its striking stuccoes and dome tower, and the three-arch clock gate, the Torre del Reloj, are just two of the many landmarks of this enchanting city dotted with many squares and sidewalk cafés. A wonderful photo stop on our Cartagena City MSC excursion is the San Felipe de Barajas fortress, a marvel of colonial Spanish military engineering. Its construction began in 1536. Slaves la-boured for more than 120 years to erect this fortress - built on high ground with dominating ap-proaches to the city by land and sea to fend off pirates - and its network of tunnels. On yet another MSC excursion, enrich your palate as you learn about the rich aromas and flavours of Colombian coffee. Introduced by the Jesuits in 1723, coffee quickly became a key crop in Colombia, which is now one of the top producers of Arabica coffee in the world. Colombia is also the world’s top producer of emeralds. If jewellery and gems fascinate you, learn all about these green precious stones and make your own emerald-studded jewellery in sterling silver during a hands-on MSC excursion that guides you step-by-step. And you don’t need to go far to explore nature. An MSC excursion takes you by canoe through mangrove tunnels to Ciénaga de la Virgen, where you can witness a diversity of birds from king-fishers and white herons to pelicans and pink-feathered roseate spoonbills. Go to Cartagena, Colombia Cruises visiting Cartagena, Colombia

Cartagena, Colombia photo — Day 12 Oct 18, 2027 Cartagena, Colombia 11:30 – 19:00 7.5 hrs ashore Cobbled streets, balconies overflowing with blooming bougainvillea and pastel-coloured buildings lining elegant plazas make Cartagena in Colombia one of the Caribbean's most photogenic cities, and a memorable stop on an MSC Caribbean and Antilles cruise. Founded in 1533, this Spanish colonial city, a UNESCO World Heritage Site, is steeped in history. Its location made it a popular target for plunderers and English pirates, and arguably features the most impressive collection of forts in the Caribbean. Today the city is eager to share its treasures with modern visitors. Magnificent colonial structures such as the 16th-century Santa Catalina Cathedral, with its striking stuccoes and dome tower, and the three-arch clock gate, the Torre del Reloj, are just two of the many landmarks of this enchanting city dotted with many squares and sidewalk cafés. A wonderful photo stop on our Cartagena City MSC excursion is the San Felipe de Barajas fortress, a marvel of colonial Spanish military engineering. Its construction began in 1536. Slaves la-boured for more than 120 years to erect this fortress - built on high ground with dominating ap-proaches to the city by land and sea to fend off pirates - and its network of tunnels. On yet another MSC excursion, enrich your palate as you learn about the rich aromas and flavours of Colombian coffee. Introduced by the Jesuits in 1723, coffee quickly became a key crop in Colombia, which is now one of the top producers of Arabica coffee in the world. Colombia is also the world’s top producer of emeralds. If jewellery and gems fascinate you, learn all about these green precious stones and make your own emerald-studded jewellery in sterling silver during a hands-on MSC excursion that guides you step-by-step. And you don’t need to go far to explore nature. An MSC excursion takes you by canoe through mangrove tunnels to Ciénaga de la Virgen, where you can witness a diversity of birds from king-fishers and white herons to pelicans and pink-feathered roseate spoonbills. Go to Cartagena, Colombia Cruises visiting Cartagena, Colombia

Day 14 Oct 20, 2027 George Town, Cayman Islands 07:00 – 16:00 9.0 hrs ashore Christopher Columbus called the Cayman Islands, with their tranquil blue waters, "Las Tortugas" for its abundance of turtles. Located between Cuba and Jamaica, the Cayman Islands are comprised of three Caribbean islands: Grand Cayman, Little Cayman and Cayman Brac. Beautiful landscapes, bountiful wildlife and colourful streets embody this British Overseas Territory, with George Town, its capital, located on Grand Cayman, the largest and most populous island. When you arrive in George Town on an MSC Caribbean and Antilles cruise, you’ll discover that wildlife conservation is at the core of Grand Cayman’s offerings. For the chance of a lifetime to swim, feed and interact with stingrays, book an MSC excursion to Stingray City, where you’ll get an up-close experience with Cayman’s most graceful marine creatures. On yet another MSC excursion to the Cayman Turtle Centre, encounter the green turtles that return each and every year to lay their eggs on one of the beaches, visit the turtle hatchery, snorkel alongside yearlings in the Turtle Lagoon and meet the island’s endangered blue iguanas. For a special experience, ride horses bareback into the Caribbean Sea at Barker’s National Park on an exclusive Martha Stewart excursion curated just for MSC Cruises, followed by lunch at Vivo café, a spot beloved for its mostly vegan cuisine, with organic ingredients sourced straight from local farms. To learn about Cayman’s past and culture, explore Cayman Heritage House and visit the sumptuous Government House, the governor's residence built in 1964 located in front of Seven Mile Beach, one of the most prestigious beaches of Grand Cayman, in the heart of West Bay. Shopaholics will also delight in this destination. The Cayman Islands are entirely duty free. You just have to choose what catches your fancy among the myriad of watches, liqueurs, jewellery and porcelain on offer. Go to George Town, Cayman Islands Cruises visiting George Town, Cayman Islands

Day 16 Oct 22, 2027 Tampa Arrives 05:00 Set sail from Florida’s Gulf Coast and you’ll discover just how convenient — and action-packed — cruises out of Tampa can be. Welcome to one of Florida’s busiest ports — where the historically Cuban district of Ybor City, the aquarium, city shopping and local art museums are all in easy reach. Wide beaches and urban adventures are also at your fingertips when you book a Carnival cruise from Tampa. And come nightfall, 7th Avenue in Ybor City heats up, Latin-style. Go to Tampa Cruises visiting Tampa

Tampa photo — Day 16 Oct 22, 2027 Tampa Arrives 05:00 Set sail from Florida’s Gulf Coast and you’ll discover just how convenient — and action-packed — cruises out of Tampa can be. Welcome to one of Florida’s busiest ports — where the historically Cuban district of Ybor City, the aquarium, city shopping and local art museums are all in easy reach. Wide beaches and urban adventures are also at your fingertips when you book a Carnival cruise from Tampa. And come nightfall, 7th Avenue in Ybor City heats up, Latin-style. Go to Tampa Cruises visiting Tampa

Pricing

Lowest fare we've tracked over the observed 89-day span: $874 · range $874–$1,233

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $1,986

$132 / night

Fare rows

Interior Stateroom - Guaranteed

Cabin grade

Available

from $1,986

$132 / night

per person · incl. taxes

Interior

Cabin grade

Available

from $2,136

$142 / night

per person · incl. taxes

Interior

Cabin grade

Available

from $2,186

$145 / night

per person · incl. taxes

Interior

Cabin grade

Available

from $2,246

$149 / night

per person · incl. taxes

Interior

Cabin grade

Available

from $2,246

$149 / night

per person · incl. taxes

Interior

Cabin grade

Available

from $2,276

$151 / night

per person · incl. taxes

Oceanview

from $2,256

$150 / night

Fare rows

Ocean View - Guaranteed

Cabin grade

Available

from $2,256

$150 / night

per person · incl. taxes

Ocean View

Cabin grade

Available

from $2,356

$157 / night

per person · incl. taxes

Ocean View

Cabin grade

Available

from $2,376

$158 / night

per person · incl. taxes

Ocean View

Cabin grade

Available

from $2,396

$159 / night

per person · incl. taxes

Ocean View

Cabin grade

Available

from $2,426

$161 / night

per person · incl. taxes

Ocean View

Cabin grade

Available

from $2,436

$162 / night

per person · incl. taxes

Oceanview

Cabin grade

Available

from $2,446

$163 / night

per person · incl. taxes

Ultra Spacious Ocean View

Cabin grade

Available

from $4,028

$268 / night

per person · incl. taxes

Balcony

from $4,048

$269 / night

Fare rows

Ocean View Balcony

Cabin grade

Available

from $4,048

$269 / night

per person · incl. taxes

Ocean View Balcony

Cabin grade

Available

from $4,068

$271 / night

per person · incl. taxes

Connecting Balcony

Cabin grade

Available

from $4,247

$283 / night

per person · incl. taxes

Spacious Ocean View Balcony

Cabin grade

Available

from $4,337

$289 / night

per person · incl. taxes

Suite

Not available

Prices verified Jun 21, 2026

Prices come from third-party data feeds via Royal Caribbean and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

All cabin grades (38) Detailed cabin specs available at booking.

Name	Supplier code	Type
Spacious Ocean View Balcony	1B	Balcony
Ocean View Balcony	1D	Balcony
Spacious Ocean View Balcony	2B	Balcony
Ocean View Balcony	2D	Balcony
Spacious Ocean View Balcony	3B	Balcony
Ocean View Balcony	3D	Balcony
Spacious Ocean View Balcony	4B	Balcony
Ocean View Balcony	4D	Balcony
Ocean View Balcony	5D	Balcony
Connecting Balcony	CB	Balcony
Spacious Sunset Balcony	SG	Balcony
Balcony Stateroom - Guaranteed	XB	Balcony
Ocean View Balcony Quad Guaranteed	XQ	Balcony
Interior	1V	Inside
Interior	2V	Inside
Studio Interior	2W	Inside
Interior	3V	Inside
Interior	4V	Inside
Interior	5V	Inside
Interior Stateroom - Guaranteed	ZI	Inside
Interior Quad Guaranteed	ZQ	Inside
Ultra Spacious Ocean View	1K	Oceanview
Ocean View	1N	Oceanview
Ocean View	2N	Oceanview
Ocean View	3N	Oceanview
Spacious Ocean View	4M	Oceanview
Ocean View	4N	Oceanview
Ocean View	5N	Oceanview
Oceanview	CO	Oceanview
Ocean View - Guaranteed	YO	Oceanview
Ocean View Quad Guaranteed	YQ	Oceanview
Grand Suite - 1 Bedroom	GS	Suite
Junior Suite	J3	Suite
Owner’s Suite - 1 Bedroom	OS	Suite
Owner’s Suite - 2 Bedroom	OT	Suite
Royal Suite - 1 Bedroom	RS	Suite
Ocean View Suite - 2 Bedroom (No Balcony)	VT	Suite
Suite - Guaranteed	WS	Suite