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21-night Adriatic cruise: Civitavecchia, Rome to Athens (Piraeus), Greece on Nieuw Amsterdam

The 21-Day Around Italy's Boot: Greek Isles & Istanbul Overnight is a 21-night Adriatic cruise aboard Nieuw Amsterdam, operated by Holland America Line. Departing Civitavecchia, Rome on September 10, 2028 and arriving in Athens (Piraeus), Greece on October 1, 2028, the voyage visits 16 ports including Naples, Messina, Italy, Malta. Fares start from $6,079 per person.

Length
21 nights
Departs
Sep 10, 2028
Returns
Oct 1, 2028
Ports of call
16
Days at sea
7

Voyage code I859A

Civitavecchia, Rome

21 nights · Adriatic

from $6,079 pp

via CruiseDirect

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Why this route stands out

A closer look at the journey

Civitavecchia, Rome

All roads lead to Rome, and with good reason - this city is one of the world’s most thrilling, offering unmatched history along every street. An evocative, inspiring and utterly artistic capital of unrivalled cultural impact, Rome is a city of back-to-back landmarks, which will take you on an exhilarating journey through the ages. This may be one of the world’s oldest cities, but it’s well and truly lived in. The ruins are punctuated with murmuring cafes, and the outdoor seating of restaurants sprawls out across piazzas, enticing you to sample tangles of creamy pasta and crispy pizzas. Rome’s incredible Roman Forum is littered with the ruins of its ancient administrations, which have stood firm for 2,000 years, since the times when the area was the centre of the Western world. Few sites are more simultaneously beautiful and haunting than that of the storied Colosseum, which looms deep into Rome’s rich blue sky. Take a tour to learn details of the grisly goings-on within. The best way to experience Rome is to wander its streets, gelato in hand. There is a lot to see here - whether it’s the domed spectacle of the Pantheon, or the elaborate flowing waters and artistry of the Trevi Fountain. Vatican City is an astonishing, colossal display of Catholic grandeur, while the Spanish Steps – crowned by the Trinità dei Monti church – offer a beautiful spot to gather and soak up the lively atmosphere of this humming city. With so much on the to-do list, you’ll relish the breaks you take, enjoying simple pleasures like a strong espresso, or fresh pasta with tomato sauce and ripped basil.

Naples

Rising behind the wide curve of its bay with brooding Mount Vesuvius and the deep blue sea as a backdrop, Naples, Italy enjoys a magnificent natural setting. It is the third-largest city in Italy after Rome and Milan, and arguably the most colorful and seductive of them all: Splendor and squalor live side by side in 21st-century Naples, and the mix is intoxicating. Cruise to Naples, home to world-class museums and attractions. Naples has something for everyone - superb restaurants, eclectic shopping, a thriving contemporary art scene and an edgy and vibrant street life. But once you’ve had enough of the pounding traffic and jostling crowds while sightseeing in Naples, there are endless opportunities for exploration further afield. The celebrated Roman ruins of Pompeii and Herculaneum, both victims of Vesuvius’ devastating 79 C.E. eruption, lie just south of the city. Explore Naples' history or take a short ride over to the island of Capri on a Naples shore excursion. The delightful town of Sorrento and the magnificent scenery of the Amalfi Coast are also within easy reach, and the dolce vita glamour of Capri—not to mention the healing thermal waters of Ischia—are a short hydrofoil hop from the mainland. Naples cruises offer a perfect mix of cultural and natural attractions.

Messina, Italy

Messina may well be your first sight of Sicily, and – from your MSC holiday cruise ship – it’s a fine one, the glittering town spread up the hillside beyond its sickle-shaped Mediterranean harbour. On a shore excursion you can discover Messina’s most important monument, the Duomo, which epitomizes the city’s phoenix-like ability to re-create itself from the ashes of its last disaster. It’s the reconstruction of a twelfth-century cathedral erected by Roger II, one of a series of great Norman churches of Sicily that include the sumptuous cathedrals of Palermo and Cefalù. The Duomo’s detached campanile, or bell tower, claims to be the largest astronomical clock in the world, and puts on its best show at noon every day, when a bronze lion (Messina’s ancient emblem) unleashes a mighty roar over the city that can be quite alarming if you’re not expecting it! Just back from the Duomo, the truncated section of the twelfth-century Chiesa Annunziata dei Catalani squats below pavement level, and is Messina’s only surviving example of Arab/Norman church-building. When you are cruising the Mediterranean Sea with MSC Cruises, the most obvious excursion from Messina is to the almost too charming hill town of Taormina, spectacularly located on a rocky bluff between the Ionian Sea and the soaring peak of Mount Etna, whose summit with its bleak lava wilderness is one of the most memorable landscapes Italy has to offer. Once the beloved retreat of poets and writers, Taormina is now the most illustrious resort on the entire island, captivating its visitors with its famous ancient theatre, grand hotels and engaging small-town charm.

Price tracking

Today’s fare, in context

Price history

All
Fare details

Fare details

Per person · taxes & fees included
Current fares
Verified 17 hours ago
Inside
$6,079
Oceanview
$6,229
Balcony
$8,229
Suite
$10,279
Tracked range
11 days
Price history by cabin type
CabinCurrentLowestHighest
Inside $6,079 $6,079 on Aug 25 $6,079 on Aug 25
Oceanview $6,229 $6,229 on Aug 25 $6,229 on Aug 25
Balcony $8,229 $8,229 on Aug 25 $8,229 on Aug 25
Suite $10,279 $10,279 on Aug 25 $10,279 on Aug 25
Cabin grades
34 total
Verandah StateroomBalcony · V
Verandah StateroomBalcony · VA
Verandah StateroomBalcony · VB
Verandah StateroomBalcony · VC
Verandah StateroomBalcony · VD
Verandah StateroomBalcony · VE
Verandah StateroomBalcony · VF
Verandah StateroomBalcony · VH
Verandah Spa StateroomBalcony · VQ
Large Interior StateroomInside · I
Interior Spa StateroomInside · IQ
Large/Standard Inside StateroomInside · J
Large/Standard Inside StateroomInside · K
Standard Interior StateroomInside · L
Standard Interior StateroomInside · M
Standard Interior StateroomInside · MM
Standard Interior StateroomInside · N
Large Ocean view StateroomOceanview · C
Large Ocean view Spa StateroomOceanview · CQ
Large Ocean view StateroomOceanview · D
Large Ocean view StateroomOceanview · DD
Large Ocean view StateroomOceanview · E
Large Ocean view StateroomOceanview · F
Large Ocean view Stateroom (Partial Sea View)Oceanview · G
Large Ocean view Stateroom (Fully Obstructed View)Oceanview · H
Large Ocean view Stateroom (Fully Obstructed View)Oceanview · HH
Pinnacle SuiteSuite · PS
Neptune SuiteSuite · SA
Neptune SuiteSuite · SB
Neptune SuiteSuite · SC
Neptune Spa SuiteSuite · SQ
Signature SuiteSuite · SS
Signature SuiteSuite · SY
Signature SuiteSuite · SZ

○ = last seen (sold out or delisted). · Verified 17 hours ago.

Lowest fares with no residency, age, or service requirement — verify eligibility at booking. How our pricing works

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $6,079

$289 / night

Fare rows

Standard Interior Stateroom

Cabin grade

Available

from $6,079

$289 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $6,139

$292 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $6,169

$293 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $6,199

$295 / night

per person · incl. taxes & fees

Large/Standard Inside Stateroom

Cabin grade

Available

from $6,229

$296 / night

per person · incl. taxes & fees

Large/Standard Inside Stateroom

Cabin grade

Available

from $6,259

$298 / night

per person · incl. taxes & fees

Large Interior Stateroom

Cabin grade

Available

from $6,289

$299 / night

per person · incl. taxes & fees

Interior Spa Stateroom

Cabin grade

Available

from $6,319

$300 / night

per person · incl. taxes & fees

Oceanview

from $6,229

$296 / night

Fare rows

Large Ocean view Stateroom (Fully Obstructed View)

Cabin grade

Available

from $6,229

$296 / night

per person · incl. taxes & fees

Large Ocean view Stateroom (Fully Obstructed View)

Cabin grade

Available

from $6,319

$300 / night

per person · incl. taxes & fees

Large Ocean view Stateroom (Partial Sea View)

Cabin grade

Available

from $6,389

$304 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $6,679

$318 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $6,769

$322 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $6,839

$325 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $6,909

$329 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $6,979

$332 / night

per person · incl. taxes & fees

Large Ocean view Spa Stateroom

Cabin grade

Available

from $7,049

$335 / night

per person · incl. taxes & fees

Balcony

from $8,229

$391 / night

Fare rows

Verandah Stateroom

Cabin grade

Available

from $8,229

$391 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $8,429

$401 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $8,579

$408 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $8,699

$414 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $8,819

$419 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $8,939

$425 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $9,059

$431 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $9,179

$437 / night

per person · incl. taxes & fees

Verandah Spa Stateroom

Cabin grade

Available

from $9,299

$442 / night

per person · incl. taxes & fees

Suite

from $10,279

$489 / night

Fare rows

Signature Suite

Cabin grade

Available

from $10,279

$489 / night

per person · incl. taxes & fees

Signature Suite

Cabin grade

Available

from $10,679

$508 / night

per person · incl. taxes & fees

Signature Suite

Cabin grade

Available

from $11,079

$527 / night

per person · incl. taxes & fees

Neptune Suite

Cabin grade

Available

from $13,089

$623 / night

per person · incl. taxes & fees

Neptune Suite

Cabin grade

Available

from $13,899

$661 / night

per person · incl. taxes & fees

Prices verified Sep 3, 2026

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The journey

21 nights, in order

Civitavecchia, Rome

Day 1 Sep 10, 2028

Civitavecchia, Rome

All roads lead to Rome, and with good reason - this city is one of the world’s most thrilling, offering unmatched history along every street.

Explore Civitavecchia, Rome

Day by day

The full itinerary

25 scheduled calls
Nieuw Amsterdam

Your ship

Nieuw Amsterdam

The second of Holland America’s Signature Class ships, Nieuw Amsterdam, celebrates historic New York City with an inspired design and art collection. While on board, rejuvenate in the tranquil Spa & Salon, play pickleball at sea, or enjoy a tantalizing meal at fine dining restaurants. When you’re in the mood for music, Billboard Onboard fills the room with chart-topping hits.

5★ 86,700 GT 2,106 Passengers Built 2010
Nieuw Amsterdam ship guide Search cruises on Nieuw Amsterdam

Deck plans

Deck plan for DECK 1 - MAIN DECK

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from $6,079 pp

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