Rome To Istanbul

The Rome To Istanbul is a 9-night Europe cruise aboard Sirena, operated by Oceania Cruises. Departing Civitavecchia, Rome on March 29, 2027, the voyage visits 10 ports. Fares start from $2,899 per person.

Length: 9 nights
Departs: Mar 29, 2027
Returns: Apr 7, 2027
Ports of call: 10

Itinerary

Day 1 Jul 19, 2027 Civitavecchia, Rome Departs 17:00 All roads lead to Rome, and with good reason - this city is one of the world’s most thrilling, offering unmatched history along every street. An evocative, inspiring and utterly artistic capital of unrivalled cultural impact, Rome is a city of back-to-back landmarks, which will take you on an exhilarating journey through the ages. This may be one of the world’s oldest cities, but it’s well and truly lived in. The ruins are punctuated with murmuring cafes, and the outdoor seating of restaurants sprawls out across piazzas, enticing you to sample tangles of creamy pasta and crispy pizzas. Rome’s incredible Roman Forum is littered with the ruins of its ancient administrations, which have stood firm for 2,000 years, since the times when the area was the centre of the Western world. Few sites are more simultaneously beautiful and haunting than that of the storied Colosseum, which looms deep into Rome’s rich blue sky. Take a tour to learn details of the grisly goings-on within. The best way to experience Rome is to wander its streets, gelato in hand. There is a lot to see here - whether it’s the domed spectacle of the Pantheon, or the elaborate flowing waters and artistry of the Trevi Fountain. Vatican City is an astonishing, colossal display of Catholic grandeur, while the Spanish Steps – crowned by the Trinità dei Monti church – offer a beautiful spot to gather and soak up the lively atmosphere of this humming city. With so much on the to-do list, you’ll relish the breaks you take, enjoying simple pleasures like a strong espresso, or fresh pasta with tomato sauce and ripped basil. Civitavecchia, Rome port guide Search cruises visiting Civitavecchia, Rome

Day 2 Jul 20, 2027 Salerno 07:00 – 17:00 10.0 hrs ashore Situated between two of Italy’s most beautiful and best-known destinations, the Amalfi Coast and Cilento National Park, the lively city of Salerno is – perhaps unsurprisingly, but not justifiably – overlooked by many visitors to, and explorers of, the gorgeous Campania region. However, the loss of the ‘over lookers’ is certainly the gain of those who do take the time to visit and explore Salerno; there are centuries of rich history – influenced by the Romans, Goths and Byzantines – to delve into here, landmarks, monuments and museums and aplenty awaiting discovery, and authentic local life to immerse yourself in. Whether you choose to see the medieval churches and capture the gritty elegance of the neighbourhood trattorias; sample traditional cuisine at the finest restaurants, or people watch at one of the cafés over a proper Italian espresso; or take a stroll along the picturesque, tree-lined promenade, Salerno is sure to get under your skin. Salerno port guide Search cruises visiting Salerno

Salerno photo — Day 2 Jul 20, 2027 Salerno 07:00 – 17:00 10.0 hrs ashore Situated between two of Italy’s most beautiful and best-known destinations, the Amalfi Coast and Cilento National Park, the lively city of Salerno is – perhaps unsurprisingly, but not justifiably – overlooked by many visitors to, and explorers of, the gorgeous Campania region. However, the loss of the ‘over lookers’ is certainly the gain of those who do take the time to visit and explore Salerno; there are centuries of rich history – influenced by the Romans, Goths and Byzantines – to delve into here, landmarks, monuments and museums and aplenty awaiting discovery, and authentic local life to immerse yourself in. Whether you choose to see the medieval churches and capture the gritty elegance of the neighbourhood trattorias; sample traditional cuisine at the finest restaurants, or people watch at one of the cafés over a proper Italian espresso; or take a stroll along the picturesque, tree-lined promenade, Salerno is sure to get under your skin. Salerno port guide Search cruises visiting Salerno

Day 3 Jul 21, 2027 Palermo 07:00 – 18:00 11.0 hrs ashore The capital of Sicily is situated on a crescent-shaped bay on the island's north coast. Once the intellectual capital of southern Europe, Palermo has always been at the crossroads of civilization. Due to its favourable location, Sicily's most interesting city has attracted almost every people and culture touching the Mediterranean world. Its most unique characteristic is a harmonious blend of Arab-Norman cultures mixed with Byzantine and Jewish elements, which created some unforgettable and resplendent works of art. Phoenician traders first colonized Palermo in the 6th-century BC, but it was the Carthaginians, who built the important fortress here that caught the covetous eye of the Romans. After the first Punic War, the Romans took control of the city in the 3rd-century BC. Following several invasions by the Vandals, Sicily was settled by Arabs, who made the country an emirate and Palermo a showpiece capital that rivalled in splendour both Cordoba and Cairo. The city became a magical place of palaces and mosques, minarets and palm trees. In the 11th-century Palermo was conquered by the Norman ruler, Roger de Hauteville. During the Normans' hundred-year occupation, the city experienced a remarkable period of enlightenment and a flourishing of the arts. Counting a population of more than 300,000, Palermo became the centre of Norman rule and one of the most important trading centres between East and West. Eventually, Palermo was incorporated into the “Kingdom of the Two Sicilies” under the Swabian ruler Frederick II, known as the Holy Roman Emperor. After the bloody Sicilian Vespers uprising in 1282, the Spanish took control and brought the Inquisition to Palermo. Some historians believe that the nature of the Inquisition helped foster the protective secret societies that eventually evolved into the Mafia. Today, visitors can still experience the legacy of Palermo's rich past. Great Arab-Norman buildings include the Cappella Palatina, La Martorana, San Giovanni degli Eremiti and, a few miles outside the city, the Cathedral of Monreale. Palermo's bustling streets and animated markets give the town an Oriental feel. The Quattro Canti, or Four Corners, is the monumental crossroads laid out in 1608-1620 at the central intersection of the four longest and straightest streets of the city. North of Piazza Castelnuovo lie the avenues of the new city. Most sights are scattered along three major streets: Corso Vittorio Emanuele, Via Maqueda and Via Roma. A vigorous metropolis with a strong historical profile, Palermo is packed with interesting sights, which make it an enriching and enjoyable place to explore. Palermo port guide Search cruises visiting Palermo

Palermo photo — Day 3 Jul 21, 2027 Palermo 07:00 – 18:00 11.0 hrs ashore The capital of Sicily is situated on a crescent-shaped bay on the island's north coast. Once the intellectual capital of southern Europe, Palermo has always been at the crossroads of civilization. Due to its favourable location, Sicily's most interesting city has attracted almost every people and culture touching the Mediterranean world. Its most unique characteristic is a harmonious blend of Arab-Norman cultures mixed with Byzantine and Jewish elements, which created some unforgettable and resplendent works of art. Phoenician traders first colonized Palermo in the 6th-century BC, but it was the Carthaginians, who built the important fortress here that caught the covetous eye of the Romans. After the first Punic War, the Romans took control of the city in the 3rd-century BC. Following several invasions by the Vandals, Sicily was settled by Arabs, who made the country an emirate and Palermo a showpiece capital that rivalled in splendour both Cordoba and Cairo. The city became a magical place of palaces and mosques, minarets and palm trees. In the 11th-century Palermo was conquered by the Norman ruler, Roger de Hauteville. During the Normans' hundred-year occupation, the city experienced a remarkable period of enlightenment and a flourishing of the arts. Counting a population of more than 300,000, Palermo became the centre of Norman rule and one of the most important trading centres between East and West. Eventually, Palermo was incorporated into the “Kingdom of the Two Sicilies” under the Swabian ruler Frederick II, known as the Holy Roman Emperor. After the bloody Sicilian Vespers uprising in 1282, the Spanish took control and brought the Inquisition to Palermo. Some historians believe that the nature of the Inquisition helped foster the protective secret societies that eventually evolved into the Mafia. Today, visitors can still experience the legacy of Palermo's rich past. Great Arab-Norman buildings include the Cappella Palatina, La Martorana, San Giovanni degli Eremiti and, a few miles outside the city, the Cathedral of Monreale. Palermo's bustling streets and animated markets give the town an Oriental feel. The Quattro Canti, or Four Corners, is the monumental crossroads laid out in 1608-1620 at the central intersection of the four longest and straightest streets of the city. North of Piazza Castelnuovo lie the avenues of the new city. Most sights are scattered along three major streets: Corso Vittorio Emanuele, Via Maqueda and Via Roma. A vigorous metropolis with a strong historical profile, Palermo is packed with interesting sights, which make it an enriching and enjoyable place to explore. Palermo port guide Search cruises visiting Palermo

Day 4 Jul 22, 2027 Catania, Sicily 07:00 – 16:00 9.0 hrs ashore There’s a famous centuries-old quote about how important Sicily is — basically, if you skip it when visiting Italy, you might as well have just stayed home. We don’t exactly agree, but we know where the guy was coming from. Catania is the island’s second-largest city and an excellent place to kick off an exploration of Sicily. There’s no missing the gigantic Mt. Etna volcano — really, it’s impossible since it literally overshadows much of the island’s eastern region, and Catania puts you right in a primo position to see it. Compared to Etna, historical sites from Greek and Roman times are only a couple-thousand years old, but you can see them all — and some are even still in use today, like the amphitheater in Siracusa. Piazza Armerina features a villa once home to a Roman emperor, and today a UNESCO World Heritage Site, one that’s still decked out in well-preserved mosaics. Also, don’t miss the nearby town of Savoca, which you actually may have already seen… in a famous mobster trilogy. Capiche? Catania, Sicily port guide Search cruises visiting Catania, Sicily

Catania, Sicily photo — Day 4 Jul 22, 2027 Catania, Sicily 07:00 – 16:00 9.0 hrs ashore There’s a famous centuries-old quote about how important Sicily is — basically, if you skip it when visiting Italy, you might as well have just stayed home. We don’t exactly agree, but we know where the guy was coming from. Catania is the island’s second-largest city and an excellent place to kick off an exploration of Sicily. There’s no missing the gigantic Mt. Etna volcano — really, it’s impossible since it literally overshadows much of the island’s eastern region, and Catania puts you right in a primo position to see it. Compared to Etna, historical sites from Greek and Roman times are only a couple-thousand years old, but you can see them all — and some are even still in use today, like the amphitheater in Siracusa. Piazza Armerina features a villa once home to a Roman emperor, and today a UNESCO World Heritage Site, one that’s still decked out in well-preserved mosaics. Also, don’t miss the nearby town of Savoca, which you actually may have already seen… in a famous mobster trilogy. Capiche? Catania, Sicily port guide Search cruises visiting Catania, Sicily

Day 5 Jul 23, 2027 Zakynthos, Greece 13:00 – 20:00 7.0 hrs ashore A favorite of the Venetians during their three centuries of rule, Zakinthos today is increasingly popular with pleasure-seekers from throughout the world. Although virtually destroyed by an earthquake and fire in 1953, the town was painstakingly rebuilt stone by stone by its citizens, who remain fiercely proud of their island and its history. Explore Solomos Square and the fascinating Museum of Post-Byzantine Art with its fine collection of templos, carved, gilded icon screens. Shoppers will find no shortage of boutiques, particularly around St. Mark's Square. Above it all stands the ancient castle, complete with fortified walls, which once provided safety to the Medieval population. The views are excellent. Special Note: October 28 is a national holiday in Greece. Zakynthos, Greece port guide Search cruises visiting Zakynthos, Greece

Day 6 Jul 24, 2027 Gythion 09:00 – 18:00 9.0 hrs ashore One of the most beautiful parts of this region of the Peloponnese is the plain of Laconia which extends from Sparta to the port of Gythion. The many neo-classical houses of this harbor town are built on the slopes of Mount Kourmaros. Aside from its remaining ancient theater and cultural museum, visitors can enjoy local beaches and a variety of dining opportunities. The inhabitants of Gythion claim Hercules and Apollo as its founders. According to mythology, Paris and Helen of Troy were reputed to have spent their first night together on nearby ancient Kranae, now called Marathonissi. Enlarging the natural harbor, it was used by the Spartans as their naval base and the main port of trade. Today Gythion is visited mostly for its scenic beauty and access to numerous historical sites. These include the cliffside city of Mistra, one of the finest surviving examples of Byzantine architecture in Greece, and ancient Sparta.

Day 7 Jul 25, 2027 Mykonos 07:00 – 19:00 12.0 hrs ashore Think of a trip to Greece and you will imagine Mykonos. The port of Mykonos, or perhaps it would be more correct to say of Chora, is located on the west coast of the island. The Cyclades islands in the Aegean are wonderful and the beaches are no less marvellous, with the pleasant distinction of being among the most festive in the archipelago. After docking at the port of Mykonos, enjoy the numerous natural coves, beaches and cliffs of this beautiful island. You can enjoy the clean, azure sea of Paradise Beach, while in the evening let yourself be carried away by the rhythm of this cosmopolitan and youthful island. The harbour district, the Kastro, is known as the 'little Venice'. In its alleys, the shops and restaurants alternate with white houses with blue doors and windows. On a trip to Mykonos, take advantage of the stop to go on shore excursions, stroll through the maze of streets and alleys where you can discover the beauty of the architecture and the design of the city. The small white houses with shutters as blue as the sky, the pigeon houses and the numerous small churches of Mykonos will simply enchant you. Mykonos port guide Search cruises visiting Mykonos

Mykonos photo — Day 7 Jul 25, 2027 Mykonos 07:00 – 19:00 12.0 hrs ashore Think of a trip to Greece and you will imagine Mykonos. The port of Mykonos, or perhaps it would be more correct to say of Chora, is located on the west coast of the island. The Cyclades islands in the Aegean are wonderful and the beaches are no less marvellous, with the pleasant distinction of being among the most festive in the archipelago. After docking at the port of Mykonos, enjoy the numerous natural coves, beaches and cliffs of this beautiful island. You can enjoy the clean, azure sea of Paradise Beach, while in the evening let yourself be carried away by the rhythm of this cosmopolitan and youthful island. The harbour district, the Kastro, is known as the 'little Venice'. In its alleys, the shops and restaurants alternate with white houses with blue doors and windows. On a trip to Mykonos, take advantage of the stop to go on shore excursions, stroll through the maze of streets and alleys where you can discover the beauty of the architecture and the design of the city. The small white houses with shutters as blue as the sky, the pigeon houses and the numerous small churches of Mykonos will simply enchant you. Mykonos port guide Search cruises visiting Mykonos

Day 8 Jul 26, 2027 Volos 08:00 – 18:00 10.0 hrs ashore Volos is a commercial and industrial city; it is Greece's third-largest port. Much of it has been rebuilt after a severe earthquake in 1955. The location in the gulf of the same name and near scenic Mount Pelion ensures this town an attractive setting. Interesting sites in the surrounding areas include imposing monasteries perched atop craggy mountains and a fine Archaeological Museum. Volos was founded in the 14th century in an area which has been occupied by man since the Neolithic era. A short distance out of Volos, the second millennium saw the establishment of the Mycenaen city of Iolkos, seat of King Pelias and home of his nephew Jason, who sailed from here with the Argonauts. Remains of Mycenaen buildings have been discovered near the river, where a palace stood around 1400 B.C. The main reason visitors come to Volos is to depart on excursions to the monasteries of Meteora. Their lofty position atop gigantic pinnacles makes them the area's foremost attraction. Volos port guide Search cruises visiting Volos

Volos photo — Day 8 Jul 26, 2027 Volos 08:00 – 18:00 10.0 hrs ashore Volos is a commercial and industrial city; it is Greece's third-largest port. Much of it has been rebuilt after a severe earthquake in 1955. The location in the gulf of the same name and near scenic Mount Pelion ensures this town an attractive setting. Interesting sites in the surrounding areas include imposing monasteries perched atop craggy mountains and a fine Archaeological Museum. Volos was founded in the 14th century in an area which has been occupied by man since the Neolithic era. A short distance out of Volos, the second millennium saw the establishment of the Mycenaen city of Iolkos, seat of King Pelias and home of his nephew Jason, who sailed from here with the Argonauts. Remains of Mycenaen buildings have been discovered near the river, where a palace stood around 1400 B.C. The main reason visitors come to Volos is to depart on excursions to the monasteries of Meteora. Their lofty position atop gigantic pinnacles makes them the area's foremost attraction. Volos port guide Search cruises visiting Volos

Day 9 Jul 27, 2027 Kapez (Canakkale) 08:00 – 18:00 10.0 hrs ashore Blend world cultural heritage and archaeological findings with exquisite nature, and you get this small Aegean city packed with prominent treasures. Soak up local culture as you visit Ottoman Empire ceramic museums, fortresses, art and the Suvla wine factory. Step back in time to a classical world of myth and legend amid Troy’s ancient ruins and the immortal battlefields of Gallipoli. Then slow down to discover restful green forests, fresh springs and the wild beauty of Mount Ida. Where green greets blue, dive into Turkey's only underwater national park to meet monk seals in underwater caves, or find inner calm on one of the beautiful beaches. With boundaries touching both Europe and Asia and surrounded by an abundance of nature, you’ll enjoy this mythological and historically rich island in great peace of mind.

Day 10 Jul 28, 2027 Istanbul Arrives 07:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Istanbul port guide Search cruises visiting Istanbul

Istanbul photo — Day 10 Jul 28, 2027 Istanbul Arrives 07:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Istanbul port guide Search cruises visiting Istanbul

Pricing

Lowest fare we've tracked over the observed 89-day span: $2,899 · range $2,899–$2,899

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $2,899

$322 / night

Fare rows

Inside Stateroom

Cabin grade

Available

from $2,899

$322 / night

per person · incl. taxes

Inside Stateroom

Cabin grade

Available

from $2,999

$333 / night

per person · incl. taxes

Oceanview

from $3,149

$349 / night

Fare rows

Ocean View Stateroom

Cabin grade

Available

from $3,149

$349 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $3,349

$372 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $3,499

$388 / night

per person · incl. taxes

Solo Oceanview Stateroom

Cabin grade

Available

from $6,899

$766 / night

per person · incl. taxes

Balcony

from $4,799

$533 / night

Fare rows

Veranda Stateroom

Cabin grade

Available

from $4,799

$533 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $4,949

$549 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $5,199

$577 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $5,349

$594 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $5,499

$611 / night

per person · incl. taxes

Suite

from $6,699

$744 / night

Fare rows

Penthouse Suite

Cabin grade

Available

from $6,699

$744 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $6,999

$777 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $7,049

$783 / night

per person · incl. taxes

Vista Suite

Cabin grade

Available

from $11,049

$1,227 / night

per person · incl. taxes

Owner's Suite

Cabin grade

Available

from $13,449

$1,494 / night

per person · incl. taxes

Prices verified Jun 20, 2026

Prices come from third-party data feeds via Oceania Cruises and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

Show all 16 cabin grades

Name	Supplier code	Type
Concierge Veranda	A1	Balcony
Concierge Veranda	A2	Balcony
Concierge Veranda	A3	Balcony
Veranda Stateroom	B1	Balcony
Veranda Stateroom	B2	Balcony
Inside Stateroom	F	Inside
Inside Stateroom	G	Inside
Deluxe Ocean View Stateroom	C1	Oceanview
Deluxe Ocean View Stateroom	C2	Oceanview
Ocean View Stateroom	D	Oceanview
Solo Oceanview Stateroom	S	Oceanview
Owner's Suite	OS	Suite
Penthouse Suite	PH1	Suite
Penthouse Suite	PH2	Suite
Penthouse Suite	PH3	Suite
Vista Suite	VS	Suite