Rome To Istanbul

The Rome To Istanbul is a 9-night Europe cruise aboard Sirena, operated by Oceania Cruises. Departing Civitavecchia, Rome on March 29, 2027, the voyage visits 10 ports. Fares start from $2,799 per person.

Length: 9 nights
Departs: Mar 29, 2027
Returns: Apr 7, 2027
Ports of call: 10

from $2,799

$311 / night per person, incl. taxes & fees

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Itinerary

Day 1 May 24, 2027 Civitavecchia, Rome Departs 17:00 All roads lead to Rome, and with good reason - this city is one of the world’s most thrilling, offering unmatched history along every street. An evocative, inspiring and utterly artistic capital of unrivalled cultural impact, Rome is a city of back-to-back landmarks, which will take you on an exhilarating journey through the ages. This may be one of the world’s oldest cities, but it’s well and truly lived in. The ruins are punctuated with murmuring cafes, and the outdoor seating of restaurants sprawls out across piazzas, enticing you to sample tangles of creamy pasta and crispy pizzas. Rome’s incredible Roman Forum is littered with the ruins of its ancient administrations, which have stood firm for 2,000 years, since the times when the area was the centre of the Western world. Few sites are more simultaneously beautiful and haunting than that of the storied Colosseum, which looms deep into Rome’s rich blue sky. Take a tour to learn details of the grisly goings-on within. The best way to experience Rome is to wander its streets, gelato in hand. There is a lot to see here - whether it’s the domed spectacle of the Pantheon, or the elaborate flowing waters and artistry of the Trevi Fountain. Vatican City is an astonishing, colossal display of Catholic grandeur, while the Spanish Steps – crowned by the Trinità dei Monti church – offer a beautiful spot to gather and soak up the lively atmosphere of this humming city. With so much on the to-do list, you’ll relish the breaks you take, enjoying simple pleasures like a strong espresso, or fresh pasta with tomato sauce and ripped basil. Civitavecchia, Rome port guide Search cruises visiting Civitavecchia, Rome

Day 2 May 25, 2027 Salerno 07:00 – 17:00 10.0 hrs ashore Situated between two of Italy’s most beautiful and best-known destinations, the Amalfi Coast and Cilento National Park, the lively city of Salerno is – perhaps unsurprisingly, but not justifiably – overlooked by many visitors to, and explorers of, the gorgeous Campania region. However, the loss of the ‘over lookers’ is certainly the gain of those who do take the time to visit and explore Salerno; there are centuries of rich history – influenced by the Romans, Goths and Byzantines – to delve into here, landmarks, monuments and museums and aplenty awaiting discovery, and authentic local life to immerse yourself in. Whether you choose to see the medieval churches and capture the gritty elegance of the neighbourhood trattorias; sample traditional cuisine at the finest restaurants, or people watch at one of the cafés over a proper Italian espresso; or take a stroll along the picturesque, tree-lined promenade, Salerno is sure to get under your skin. Salerno port guide Search cruises visiting Salerno

Salerno photo — Day 2 May 25, 2027 Salerno 07:00 – 17:00 10.0 hrs ashore Situated between two of Italy’s most beautiful and best-known destinations, the Amalfi Coast and Cilento National Park, the lively city of Salerno is – perhaps unsurprisingly, but not justifiably – overlooked by many visitors to, and explorers of, the gorgeous Campania region. However, the loss of the ‘over lookers’ is certainly the gain of those who do take the time to visit and explore Salerno; there are centuries of rich history – influenced by the Romans, Goths and Byzantines – to delve into here, landmarks, monuments and museums and aplenty awaiting discovery, and authentic local life to immerse yourself in. Whether you choose to see the medieval churches and capture the gritty elegance of the neighbourhood trattorias; sample traditional cuisine at the finest restaurants, or people watch at one of the cafés over a proper Italian espresso; or take a stroll along the picturesque, tree-lined promenade, Salerno is sure to get under your skin. Salerno port guide Search cruises visiting Salerno

Day 3 May 26, 2027 Messina, Italy 07:00 – 16:00 9.0 hrs ashore Messina may well be your first sight of Sicily, and – from your MSC holiday cruise ship – it’s a fine one, the glittering town spread up the hillside beyond its sickle-shaped Mediterranean harbour. On a shore excursion you can discover Messina’s most important monument, the Duomo, which epitomizes the city’s phoenix-like ability to re-create itself from the ashes of its last disaster. It’s the reconstruction of a twelfth-century cathedral erected by Roger II, one of a series of great Norman churches of Sicily that include the sumptuous cathedrals of Palermo and Cefalù. The Duomo’s detached campanile, or bell tower, claims to be the largest astronomical clock in the world, and puts on its best show at noon every day, when a bronze lion (Messina’s ancient emblem) unleashes a mighty roar over the city that can be quite alarming if you’re not expecting it! Just back from the Duomo, the truncated section of the twelfth-century Chiesa Annunziata dei Catalani squats below pavement level, and is Messina’s only surviving example of Arab/Norman church-building. When you are cruising the Mediterranean Sea with MSC Cruises, the most obvious excursion from Messina is to the almost too charming hill town of Taormina, spectacularly located on a rocky bluff between the Ionian Sea and the soaring peak of Mount Etna, whose summit with its bleak lava wilderness is one of the most memorable landscapes Italy has to offer. Once the beloved retreat of poets and writers, Taormina is now the most illustrious resort on the entire island, captivating its visitors with its famous ancient theatre, grand hotels and engaging small-town charm. Messina, Italy port guide Search cruises visiting Messina, Italy

Messina, Italy photo — Day 3 May 26, 2027 Messina, Italy 07:00 – 16:00 9.0 hrs ashore Messina may well be your first sight of Sicily, and – from your MSC holiday cruise ship – it’s a fine one, the glittering town spread up the hillside beyond its sickle-shaped Mediterranean harbour. On a shore excursion you can discover Messina’s most important monument, the Duomo, which epitomizes the city’s phoenix-like ability to re-create itself from the ashes of its last disaster. It’s the reconstruction of a twelfth-century cathedral erected by Roger II, one of a series of great Norman churches of Sicily that include the sumptuous cathedrals of Palermo and Cefalù. The Duomo’s detached campanile, or bell tower, claims to be the largest astronomical clock in the world, and puts on its best show at noon every day, when a bronze lion (Messina’s ancient emblem) unleashes a mighty roar over the city that can be quite alarming if you’re not expecting it! Just back from the Duomo, the truncated section of the twelfth-century Chiesa Annunziata dei Catalani squats below pavement level, and is Messina’s only surviving example of Arab/Norman church-building. When you are cruising the Mediterranean Sea with MSC Cruises, the most obvious excursion from Messina is to the almost too charming hill town of Taormina, spectacularly located on a rocky bluff between the Ionian Sea and the soaring peak of Mount Etna, whose summit with its bleak lava wilderness is one of the most memorable landscapes Italy has to offer. Once the beloved retreat of poets and writers, Taormina is now the most illustrious resort on the entire island, captivating its visitors with its famous ancient theatre, grand hotels and engaging small-town charm. Messina, Italy port guide Search cruises visiting Messina, Italy

Day 4 May 27, 2027 Syracuse,Italy 07:00 – 17:00 10.0 hrs ashore A journey through culture and art. With an MSC Cruise you will immerse yourself in one of the most fascinating and historical regions in Italy. Welcome to Sicily: in the heart of the Mediterranean Sea, surrounded by crystal clear waters, this magical and welcoming land preserves traces of ancient civilizations. With a hike in the Val di Noto, declared a World Heritage Site by UNESCO, you will be able to fully enjoy the sicilian baroque, on the trail of “Commissioner Montalbano”, the famous character created by the author Andrea Camilleri. Passing through Ragusa Ibla, the ancient historical center of Ragusa, with its numerous churches and many buildings of times gone by, continuing to Scicli, where you will be able to admire the Byzantine settlements in the area of Chiafura, to finally arrive in Modica, famous not only for the delicious chocolate of Aztec origin but also for the artistic value of its buildings. Moving on to Syracuse, you will reach the island of Ortygia, the old town, connected to the mainland by the Umbertino bridge. Here, great civilizations have come and gone: from the Greeks and Phoenicians to the Romans, from the Arabs to the Byzantines, to the Normans and the Aragonese. To experience life in this city to the full you shouldn't miss a visit to the market: lose yourself among the stalls, where the sellers of fish, meat, fruits and vegetables are all proposing their goods with the typical vanniate, screams/rhymes in the local dialect. Or take an excursion to the archeological Park of Syracuse. In this site you will be able to admire, among other things, relics of Greco-Roman eras, like the Greek Theatre of the V century BC, where the playwright Aeschylus staged The Women of Aetna in 476 BC; The ear of Dionysus, 23 meter high artificial cave; the Roman Amphitheatre, carved into the rock and among the largest in Sicily; and the Ara of Ierone, the altar that was originally about 198 meters long and over 20 wide. Syracuse,Italy port guide Search cruises visiting Syracuse,Italy

Syracuse,Italy photo — Day 4 May 27, 2027 Syracuse,Italy 07:00 – 17:00 10.0 hrs ashore A journey through culture and art. With an MSC Cruise you will immerse yourself in one of the most fascinating and historical regions in Italy. Welcome to Sicily: in the heart of the Mediterranean Sea, surrounded by crystal clear waters, this magical and welcoming land preserves traces of ancient civilizations. With a hike in the Val di Noto, declared a World Heritage Site by UNESCO, you will be able to fully enjoy the sicilian baroque, on the trail of “Commissioner Montalbano”, the famous character created by the author Andrea Camilleri. Passing through Ragusa Ibla, the ancient historical center of Ragusa, with its numerous churches and many buildings of times gone by, continuing to Scicli, where you will be able to admire the Byzantine settlements in the area of Chiafura, to finally arrive in Modica, famous not only for the delicious chocolate of Aztec origin but also for the artistic value of its buildings. Moving on to Syracuse, you will reach the island of Ortygia, the old town, connected to the mainland by the Umbertino bridge. Here, great civilizations have come and gone: from the Greeks and Phoenicians to the Romans, from the Arabs to the Byzantines, to the Normans and the Aragonese. To experience life in this city to the full you shouldn't miss a visit to the market: lose yourself among the stalls, where the sellers of fish, meat, fruits and vegetables are all proposing their goods with the typical vanniate, screams/rhymes in the local dialect. Or take an excursion to the archeological Park of Syracuse. In this site you will be able to admire, among other things, relics of Greco-Roman eras, like the Greek Theatre of the V century BC, where the playwright Aeschylus staged The Women of Aetna in 476 BC; The ear of Dionysus, 23 meter high artificial cave; the Roman Amphitheatre, carved into the rock and among the largest in Sicily; and the Ara of Ierone, the altar that was originally about 198 meters long and over 20 wide. Syracuse,Italy port guide Search cruises visiting Syracuse,Italy

Day 5 May 28, 2027 Olympia (Katakolon), Greece 11:00 – 19:00 8.0 hrs ashore The small Greek port of Katakolon was developed in the 19th century to serve the thriving local trade in currants. Today it is your starting block for Olympia - birthplace of the Olympic Games. A pretty town on the banks of the River Alpheios, Olympia lies only a short drive away from the port and its historic stadium - where the first Olympic torch was lit in 776 BC and is a fascinating site to explore. You can still see the marble starting blocks used by early athletes in the 45,000-seat arena, as well as the ruins of the Temple of Hera and the gigantic Temple of Zeus - its gold and ivory statue of Zeus was one of the Seven Wonders of the ancient world. If you have already visited Olympia, you could spend your day exploring the lush wine country north of Katakolon and sampling the local vintages. Olympia (Katakolon), Greece port guide Search cruises visiting Olympia (Katakolon), Greece

Olympia (Katakolon), Greece photo — Day 5 May 28, 2027 Olympia (Katakolon), Greece 11:00 – 19:00 8.0 hrs ashore The small Greek port of Katakolon was developed in the 19th century to serve the thriving local trade in currants. Today it is your starting block for Olympia - birthplace of the Olympic Games. A pretty town on the banks of the River Alpheios, Olympia lies only a short drive away from the port and its historic stadium - where the first Olympic torch was lit in 776 BC and is a fascinating site to explore. You can still see the marble starting blocks used by early athletes in the 45,000-seat arena, as well as the ruins of the Temple of Hera and the gigantic Temple of Zeus - its gold and ivory statue of Zeus was one of the Seven Wonders of the ancient world. If you have already visited Olympia, you could spend your day exploring the lush wine country north of Katakolon and sampling the local vintages. Olympia (Katakolon), Greece port guide Search cruises visiting Olympia (Katakolon), Greece

Day 6 May 29, 2027 Gythion 07:00 – 19:00 12.0 hrs ashore One of the most beautiful parts of this region of the Peloponnese is the plain of Laconia which extends from Sparta to the port of Gythion. The many neo-classical houses of this harbor town are built on the slopes of Mount Kourmaros. Aside from its remaining ancient theater and cultural museum, visitors can enjoy local beaches and a variety of dining opportunities. The inhabitants of Gythion claim Hercules and Apollo as its founders. According to mythology, Paris and Helen of Troy were reputed to have spent their first night together on nearby ancient Kranae, now called Marathonissi. Enlarging the natural harbor, it was used by the Spartans as their naval base and the main port of trade. Today Gythion is visited mostly for its scenic beauty and access to numerous historical sites. These include the cliffside city of Mistra, one of the finest surviving examples of Byzantine architecture in Greece, and ancient Sparta.

Day 7 May 30, 2027 Mykonos 07:00 – 18:00 11.0 hrs ashore Think of a trip to Greece and you will imagine Mykonos. The port of Mykonos, or perhaps it would be more correct to say of Chora, is located on the west coast of the island. The Cyclades islands in the Aegean are wonderful and the beaches are no less marvellous, with the pleasant distinction of being among the most festive in the archipelago. After docking at the port of Mykonos, enjoy the numerous natural coves, beaches and cliffs of this beautiful island. You can enjoy the clean, azure sea of Paradise Beach, while in the evening let yourself be carried away by the rhythm of this cosmopolitan and youthful island. The harbour district, the Kastro, is known as the 'little Venice'. In its alleys, the shops and restaurants alternate with white houses with blue doors and windows. On a trip to Mykonos, take advantage of the stop to go on shore excursions, stroll through the maze of streets and alleys where you can discover the beauty of the architecture and the design of the city. The small white houses with shutters as blue as the sky, the pigeon houses and the numerous small churches of Mykonos will simply enchant you. Mykonos port guide Search cruises visiting Mykonos

Mykonos photo — Day 7 May 30, 2027 Mykonos 07:00 – 18:00 11.0 hrs ashore Think of a trip to Greece and you will imagine Mykonos. The port of Mykonos, or perhaps it would be more correct to say of Chora, is located on the west coast of the island. The Cyclades islands in the Aegean are wonderful and the beaches are no less marvellous, with the pleasant distinction of being among the most festive in the archipelago. After docking at the port of Mykonos, enjoy the numerous natural coves, beaches and cliffs of this beautiful island. You can enjoy the clean, azure sea of Paradise Beach, while in the evening let yourself be carried away by the rhythm of this cosmopolitan and youthful island. The harbour district, the Kastro, is known as the 'little Venice'. In its alleys, the shops and restaurants alternate with white houses with blue doors and windows. On a trip to Mykonos, take advantage of the stop to go on shore excursions, stroll through the maze of streets and alleys where you can discover the beauty of the architecture and the design of the city. The small white houses with shutters as blue as the sky, the pigeon houses and the numerous small churches of Mykonos will simply enchant you. Mykonos port guide Search cruises visiting Mykonos

Day 8 May 31, 2027 Skiathos, Greece 07:00 – 18:00 11.0 hrs ashore The lively island of Skiathos, one of the Sporades, boasts no less than 60 inviting beaches around its perimeter. Many of these have been developed and are easily reached by taxi or bus, while others remain more isolated and require transport by boat. The island's medieval Kastro, high atop a hillside, once protected 30 churches and 300 houses from various invaders. No organized excursions are available. Please check on board for suggestions. Skiathos, Greece port guide Search cruises visiting Skiathos, Greece

Skiathos, Greece photo — Day 8 May 31, 2027 Skiathos, Greece 07:00 – 18:00 11.0 hrs ashore The lively island of Skiathos, one of the Sporades, boasts no less than 60 inviting beaches around its perimeter. Many of these have been developed and are easily reached by taxi or bus, while others remain more isolated and require transport by boat. The island's medieval Kastro, high atop a hillside, once protected 30 churches and 300 houses from various invaders. No organized excursions are available. Please check on board for suggestions. Skiathos, Greece port guide Search cruises visiting Skiathos, Greece

Day 9 Jun 1, 2027 Kapez (Canakkale) 07:00 – 18:00 11.0 hrs ashore Blend world cultural heritage and archaeological findings with exquisite nature, and you get this small Aegean city packed with prominent treasures. Soak up local culture as you visit Ottoman Empire ceramic museums, fortresses, art and the Suvla wine factory. Step back in time to a classical world of myth and legend amid Troy’s ancient ruins and the immortal battlefields of Gallipoli. Then slow down to discover restful green forests, fresh springs and the wild beauty of Mount Ida. Where green greets blue, dive into Turkey's only underwater national park to meet monk seals in underwater caves, or find inner calm on one of the beautiful beaches. With boundaries touching both Europe and Asia and surrounded by an abundance of nature, you’ll enjoy this mythological and historically rich island in great peace of mind.

Day 10 Jun 2, 2027 Istanbul Arrives 07:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Istanbul port guide Search cruises visiting Istanbul

Istanbul photo — Day 10 Jun 2, 2027 Istanbul Arrives 07:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Istanbul port guide Search cruises visiting Istanbul

Pricing

Lowest fare we've tracked over the observed 85-day span: $2,430 · range $2,430–$2,799

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $2,799

$311 / night

Fare rows

Inside Stateroom

Cabin grade

Available

from $2,799

$311 / night

per person · incl. taxes

Oceanview

from $3,099

$344 / night

Fare rows

Ocean View Stateroom

Cabin grade

Available

from $3,099

$344 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $3,349

$372 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $3,399

$377 / night

per person · incl. taxes

Solo Oceanview Stateroom

Cabin grade

Available

from $5,899

$655 / night

per person · incl. taxes

Balcony

from $4,499

$499 / night

Fare rows

Veranda Stateroom

Cabin grade

Available

from $4,499

$499 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $4,649

$516 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $4,899

$544 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $5,049

$561 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $5,199

$577 / night

per person · incl. taxes

Suite

from $6,399

$711 / night

Fare rows

Penthouse Suite

Cabin grade

Available

from $6,399

$711 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $6,599

$733 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $6,799

$755 / night

per person · incl. taxes

Vista Suite

Cabin grade

Available

from $10,249

$1,138 / night

per person · incl. taxes

Owner's Suite

Cabin grade

Available

from $12,449

$1,383 / night

per person · incl. taxes

Prices verified Jun 21, 2026

Prices come from third-party data feeds via Oceania Cruises and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

Show all 16 cabin grades

Name	Supplier code	Type
Concierge Veranda	A1	Balcony
Concierge Veranda	A2	Balcony
Concierge Veranda	A3	Balcony
Veranda Stateroom	B1	Balcony
Veranda Stateroom	B2	Balcony
Inside Stateroom	F	Inside
Inside Stateroom	G	Inside
Deluxe Ocean View Stateroom	C1	Oceanview
Deluxe Ocean View Stateroom	C2	Oceanview
Ocean View Stateroom	D	Oceanview
Solo Oceanview Stateroom	S	Oceanview
Owner's Suite	OS	Suite
Penthouse Suite	PH1	Suite
Penthouse Suite	PH2	Suite
Penthouse Suite	PH3	Suite
Vista Suite	VS	Suite