Rome To Istanbul

9 nights Mar 29, 2027

The Rome To Istanbul is a 9-night Europe cruise aboard Sirena, operated by Oceania Cruises. Departing Civitavecchia, Rome on March 29, 2027, the voyage visits 10 ports. Fares start from $2,520 per person.

Itinerary

Day 2 Mar 30, 2027 Salerno 07:00 – 17:00 10.0 hrs ashore Situated between two of Italy’s most beautiful and best-known destinations, the Amalfi Coast and Cilento National Park, the lively city of Salerno is – perhaps unsurprisingly, but not justifiably – overlooked by many visitors to, and explorers of, the gorgeous Campania region. However, the loss of the ‘over lookers’ is certainly the gain of those who do take the time to visit and explore Salerno; there are centuries of rich history – influenced by the Romans, Goths and Byzantines – to delve into here, landmarks, monuments and museums and aplenty awaiting discovery, and authentic local life to immerse yourself in. Whether you choose to see the medieval churches and capture the gritty elegance of the neighbourhood trattorias; sample traditional cuisine at the finest restaurants, or people watch at one of the cafés over a proper Italian espresso; or take a stroll along the picturesque, tree-lined promenade, Salerno is sure to get under your skin. Go to Salerno Cruises visiting Salerno

Salerno photo — Day 2 Mar 30, 2027 Salerno 07:00 – 17:00 10.0 hrs ashore Situated between two of Italy’s most beautiful and best-known destinations, the Amalfi Coast and Cilento National Park, the lively city of Salerno is – perhaps unsurprisingly, but not justifiably – overlooked by many visitors to, and explorers of, the gorgeous Campania region. However, the loss of the ‘over lookers’ is certainly the gain of those who do take the time to visit and explore Salerno; there are centuries of rich history – influenced by the Romans, Goths and Byzantines – to delve into here, landmarks, monuments and museums and aplenty awaiting discovery, and authentic local life to immerse yourself in. Whether you choose to see the medieval churches and capture the gritty elegance of the neighbourhood trattorias; sample traditional cuisine at the finest restaurants, or people watch at one of the cafés over a proper Italian espresso; or take a stroll along the picturesque, tree-lined promenade, Salerno is sure to get under your skin. Go to Salerno Cruises visiting Salerno

Day 3 Mar 31, 2027 Syracuse,Italy 09:00 – 18:00 9.0 hrs ashore A journey through culture and art. With an MSC Cruise you will immerse yourself in one of the most fascinating and historical regions in Italy. Welcome to Sicily: in the heart of the Mediterranean Sea, surrounded by crystal clear waters, this magical and welcoming land preserves traces of ancient civilizations. With a hike in the Val di Noto, declared a World Heritage Site by UNESCO, you will be able to fully enjoy the sicilian baroque, on the trail of “Commissioner Montalbano”, the famous character created by the author Andrea Camilleri. Passing through Ragusa Ibla, the ancient historical center of Ragusa, with its numerous churches and many buildings of times gone by, continuing to Scicli, where you will be able to admire the Byzantine settlements in the area of Chiafura, to finally arrive in Modica, famous not only for the delicious chocolate of Aztec origin but also for the artistic value of its buildings. Moving on to Syracuse, you will reach the island of Ortygia, the old town, connected to the mainland by the Umbertino bridge. Here, great civilizations have come and gone: from the Greeks and Phoenicians to the Romans, from the Arabs to the Byzantines, to the Normans and the Aragonese. To experience life in this city to the full you shouldn't miss a visit to the market: lose yourself among the stalls, where the sellers of fish, meat, fruits and vegetables are all proposing their goods with the typical vanniate, screams/rhymes in the local dialect. Or take an excursion to the archeological Park of Syracuse. In this site you will be able to admire, among other things, relics of Greco-Roman eras, like the Greek Theatre of the V century BC, where the playwright Aeschylus staged The Women of Aetna in 476 BC; The ear of Dionysus, 23 meter high artificial cave; the Roman Amphitheatre, carved into the rock and among the largest in Sicily; and the Ara of Ierone, the altar that was originally about 198 meters long and over 20 wide. Go to Syracuse,Italy Cruises visiting Syracuse,Italy

Syracuse,Italy photo — Day 3 Mar 31, 2027 Syracuse,Italy 09:00 – 18:00 9.0 hrs ashore A journey through culture and art. With an MSC Cruise you will immerse yourself in one of the most fascinating and historical regions in Italy. Welcome to Sicily: in the heart of the Mediterranean Sea, surrounded by crystal clear waters, this magical and welcoming land preserves traces of ancient civilizations. With a hike in the Val di Noto, declared a World Heritage Site by UNESCO, you will be able to fully enjoy the sicilian baroque, on the trail of “Commissioner Montalbano”, the famous character created by the author Andrea Camilleri. Passing through Ragusa Ibla, the ancient historical center of Ragusa, with its numerous churches and many buildings of times gone by, continuing to Scicli, where you will be able to admire the Byzantine settlements in the area of Chiafura, to finally arrive in Modica, famous not only for the delicious chocolate of Aztec origin but also for the artistic value of its buildings. Moving on to Syracuse, you will reach the island of Ortygia, the old town, connected to the mainland by the Umbertino bridge. Here, great civilizations have come and gone: from the Greeks and Phoenicians to the Romans, from the Arabs to the Byzantines, to the Normans and the Aragonese. To experience life in this city to the full you shouldn't miss a visit to the market: lose yourself among the stalls, where the sellers of fish, meat, fruits and vegetables are all proposing their goods with the typical vanniate, screams/rhymes in the local dialect. Or take an excursion to the archeological Park of Syracuse. In this site you will be able to admire, among other things, relics of Greco-Roman eras, like the Greek Theatre of the V century BC, where the playwright Aeschylus staged The Women of Aetna in 476 BC; The ear of Dionysus, 23 meter high artificial cave; the Roman Amphitheatre, carved into the rock and among the largest in Sicily; and the Ara of Ierone, the altar that was originally about 198 meters long and over 20 wide. Go to Syracuse,Italy Cruises visiting Syracuse,Italy

Day 4 Apr 1, 2027 Olympia (Katakolon), Greece 14:00 – 23:00 9.0 hrs ashore The small Greek port of Katakolon was developed in the 19th century to serve the thriving local trade in currants. Today it is your starting block for Olympia - birthplace of the Olympic Games. A pretty town on the banks of the River Alpheios, Olympia lies only a short drive away from the port and its historic stadium - where the first Olympic torch was lit in 776 BC and is a fascinating site to explore. You can still see the marble starting blocks used by early athletes in the 45,000-seat arena, as well as the ruins of the Temple of Hera and the gigantic Temple of Zeus - its gold and ivory statue of Zeus was one of the Seven Wonders of the ancient world. If you have already visited Olympia, you could spend your day exploring the lush wine country north of Katakolon and sampling the local vintages. Go to Olympia (Katakolon), Greece Cruises visiting Olympia (Katakolon), Greece

Olympia (Katakolon), Greece photo — Day 4 Apr 1, 2027 Olympia (Katakolon), Greece 14:00 – 23:00 9.0 hrs ashore The small Greek port of Katakolon was developed in the 19th century to serve the thriving local trade in currants. Today it is your starting block for Olympia - birthplace of the Olympic Games. A pretty town on the banks of the River Alpheios, Olympia lies only a short drive away from the port and its historic stadium - where the first Olympic torch was lit in 776 BC and is a fascinating site to explore. You can still see the marble starting blocks used by early athletes in the 45,000-seat arena, as well as the ruins of the Temple of Hera and the gigantic Temple of Zeus - its gold and ivory statue of Zeus was one of the Seven Wonders of the ancient world. If you have already visited Olympia, you could spend your day exploring the lush wine country north of Katakolon and sampling the local vintages. Go to Olympia (Katakolon), Greece Cruises visiting Olympia (Katakolon), Greece

Day 5 Apr 2, 2027 Gythion 10:00 – 18:00 8.0 hrs ashore One of the most beautiful parts of this region of the Peloponnese is the plain of Laconia which extends from Sparta to the port of Gythion. The many neo-classical houses of this harbor town are built on the slopes of Mount Kourmaros. Aside from its remaining ancient theater and cultural museum, visitors can enjoy local beaches and a variety of dining opportunities. The inhabitants of Gythion claim Hercules and Apollo as its founders. According to mythology, Paris and Helen of Troy were reputed to have spent their first night together on nearby ancient Kranae, now called Marathonissi. Enlarging the natural harbor, it was used by the Spartans as their naval base and the main port of trade. Today Gythion is visited mostly for its scenic beauty and access to numerous historical sites. These include the cliffside city of Mistra, one of the finest surviving examples of Byzantine architecture in Greece, and ancient Sparta.

Day 6 Apr 3, 2027 Mykonos 10:00 – 19:00 9.0 hrs ashore Think of a trip to Greece and you will imagine Mykonos. The port of Mykonos, or perhaps it would be more correct to say of Chora, is located on the west coast of the island. The Cyclades islands in the Aegean are wonderful and the beaches are no less marvellous, with the pleasant distinction of being among the most festive in the archipelago. After docking at the port of Mykonos, enjoy the numerous natural coves, beaches and cliffs of this beautiful island. You can enjoy the clean, azure sea of Paradise Beach, while in the evening let yourself be carried away by the rhythm of this cosmopolitan and youthful island. The harbour district, the Kastro, is known as the 'little Venice'. In its alleys, the shops and restaurants alternate with white houses with blue doors and windows. On a trip to Mykonos, take advantage of the stop to go on shore excursions, stroll through the maze of streets and alleys where you can discover the beauty of the architecture and the design of the city. The small white houses with shutters as blue as the sky, the pigeon houses and the numerous small churches of Mykonos will simply enchant you. Go to Mykonos Cruises visiting Mykonos

Mykonos photo — Day 6 Apr 3, 2027 Mykonos 10:00 – 19:00 9.0 hrs ashore Think of a trip to Greece and you will imagine Mykonos. The port of Mykonos, or perhaps it would be more correct to say of Chora, is located on the west coast of the island. The Cyclades islands in the Aegean are wonderful and the beaches are no less marvellous, with the pleasant distinction of being among the most festive in the archipelago. After docking at the port of Mykonos, enjoy the numerous natural coves, beaches and cliffs of this beautiful island. You can enjoy the clean, azure sea of Paradise Beach, while in the evening let yourself be carried away by the rhythm of this cosmopolitan and youthful island. The harbour district, the Kastro, is known as the 'little Venice'. In its alleys, the shops and restaurants alternate with white houses with blue doors and windows. On a trip to Mykonos, take advantage of the stop to go on shore excursions, stroll through the maze of streets and alleys where you can discover the beauty of the architecture and the design of the city. The small white houses with shutters as blue as the sky, the pigeon houses and the numerous small churches of Mykonos will simply enchant you. Go to Mykonos Cruises visiting Mykonos

Day 7 Apr 4, 2027 Patmos 07:00 – 17:00 10.0 hrs ashore This small island in the Dodecanese enjoys a singular honor. In 1981 the Greek Parliament passed a special resolution designating Patmos a "Sacred Island." For rocky and barren Patmos claims one of the holiest spots in Christendom: the Grotto of the Revelation. Exiled from Ephesus in 95 A.D., St. John retired to Patmos spending 18 months in a cave. There he received the visions that resulted in Revelation, the last Book of the New Testament. Travelers can still view the saint's Grotto and climb the path to the 11th-century monastery of St. John the Theologian. Patmos occupies a place in classical mythology as well. Orestes fled to Patmos to escape the Furies after avenging the murder of his father Agamemnon. Go to Patmos Cruises visiting Patmos

Patmos photo — Day 7 Apr 4, 2027 Patmos 07:00 – 17:00 10.0 hrs ashore This small island in the Dodecanese enjoys a singular honor. In 1981 the Greek Parliament passed a special resolution designating Patmos a "Sacred Island." For rocky and barren Patmos claims one of the holiest spots in Christendom: the Grotto of the Revelation. Exiled from Ephesus in 95 A.D., St. John retired to Patmos spending 18 months in a cave. There he received the visions that resulted in Revelation, the last Book of the New Testament. Travelers can still view the saint's Grotto and climb the path to the 11th-century monastery of St. John the Theologian. Patmos occupies a place in classical mythology as well. Orestes fled to Patmos to escape the Furies after avenging the murder of his father Agamemnon. Go to Patmos Cruises visiting Patmos

Day 8 Apr 5, 2027 Volos 09:00 – 19:00 10.0 hrs ashore Volos is a commercial and industrial city; it is Greece's third-largest port. Much of it has been rebuilt after a severe earthquake in 1955. The location in the gulf of the same name and near scenic Mount Pelion ensures this town an attractive setting. Interesting sites in the surrounding areas include imposing monasteries perched atop craggy mountains and a fine Archaeological Museum. Volos was founded in the 14th century in an area which has been occupied by man since the Neolithic era. A short distance out of Volos, the second millennium saw the establishment of the Mycenaen city of Iolkos, seat of King Pelias and home of his nephew Jason, who sailed from here with the Argonauts. Remains of Mycenaen buildings have been discovered near the river, where a palace stood around 1400 B.C. The main reason visitors come to Volos is to depart on excursions to the monasteries of Meteora. Their lofty position atop gigantic pinnacles makes them the area's foremost attraction. Go to Volos Cruises visiting Volos

Volos photo — Day 8 Apr 5, 2027 Volos 09:00 – 19:00 10.0 hrs ashore Volos is a commercial and industrial city; it is Greece's third-largest port. Much of it has been rebuilt after a severe earthquake in 1955. The location in the gulf of the same name and near scenic Mount Pelion ensures this town an attractive setting. Interesting sites in the surrounding areas include imposing monasteries perched atop craggy mountains and a fine Archaeological Museum. Volos was founded in the 14th century in an area which has been occupied by man since the Neolithic era. A short distance out of Volos, the second millennium saw the establishment of the Mycenaen city of Iolkos, seat of King Pelias and home of his nephew Jason, who sailed from here with the Argonauts. Remains of Mycenaen buildings have been discovered near the river, where a palace stood around 1400 B.C. The main reason visitors come to Volos is to depart on excursions to the monasteries of Meteora. Their lofty position atop gigantic pinnacles makes them the area's foremost attraction. Go to Volos Cruises visiting Volos

Day 9 Apr 6, 2027 Kapez (Canakkale) 09:00 – 17:00 8.0 hrs ashore Blend world cultural heritage and archaeological findings with exquisite nature, and you get this small Aegean city packed with prominent treasures. Soak up local culture as you visit Ottoman Empire ceramic museums, fortresses, art and the Suvla wine factory. Step back in time to a classical world of myth and legend amid Troy’s ancient ruins and the immortal battlefields of Gallipoli. Then slow down to discover restful green forests, fresh springs and the wild beauty of Mount Ida. Where green greets blue, dive into Turkey's only underwater national park to meet monk seals in underwater caves, or find inner calm on one of the beautiful beaches. With boundaries touching both Europe and Asia and surrounded by an abundance of nature, you’ll enjoy this mythological and historically rich island in great peace of mind.

Day 10 Apr 7, 2027 Istanbul Arrives 08:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Go to Istanbul Cruises visiting Istanbul

Istanbul photo — Day 10 Apr 7, 2027 Istanbul Arrives 08:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Go to Istanbul Cruises visiting Istanbul

Pricing

Lowest fare we've tracked over the observed 89-day span: $2,160 · range $2,160–$2,565

Lower than 85% of peers This longer-duration sailing's from-price per night is lower than 85% of comparable sailings.

same cruise line, destination, duration, and departure window · from-price per night · as of Jun 21, 2026

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

Not available

Oceanview

from $2,520

$280 / night

Fare rows

Ocean View Stateroom

Cabin grade

Available

from $2,520

$280 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $2,655

$295 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $2,745

$305 / night

per person · incl. taxes

Ocean View Stateroom

Cabin grade

Available

from $2,799

$311 / night

per person · incl. taxes

Ocean View Stateroom

Cabin grade

Available

from $2,799

$311 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $2,949

$327 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $2,949

$327 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $3,049

$338 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $3,049

$338 / night

per person · incl. taxes

Solo Oceanview Stateroom

Cabin grade

Available

from $4,320

$480 / night

per person · incl. taxes

Solo Oceanview Stateroom

Cabin grade

Available

from $4,799

$533 / night

per person · incl. taxes

Solo Oceanview Stateroom

Cabin grade

Available

from $4,799

$533 / night

per person · incl. taxes

Balcony

from $3,555

$395 / night

Fare rows

Veranda Stateroom

Cabin grade

Available

from $3,555

$395 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $3,600

$400 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $3,780

$420 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $3,870

$430 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $3,949

$438 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $3,949

$438 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $3,960

$440 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $3,999

$444 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $3,999

$444 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $4,199

$466 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $4,199

$466 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $4,299

$477 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $4,299

$477 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $4,399

$488 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $4,399

$488 / night

per person · incl. taxes

Suite

from $5,490

$610 / night

Fare rows

Penthouse Suite

Cabin grade

Available

from $5,490

$610 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $5,625

$625 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $5,715

$635 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $6,099

$677 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $6,099

$677 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $6,249

$694 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $6,249

$694 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $6,349

$705 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $6,349

$705 / night

per person · incl. taxes

Vista Suite

Cabin grade

Available

from $9,549

$1,061 / night

per person · incl. taxes

Vista Suite

Cabin grade

Available

from $9,549

$1,061 / night

per person · incl. taxes

Owner's Suite

Cabin grade

Available

from $11,549

$1,283 / night

per person · incl. taxes

Owner's Suite

Cabin grade

Available

from $11,549

$1,283 / night

per person · incl. taxes

Prices verified Jun 21, 2026

Prices come from third-party data feeds via Oceania Cruises and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

All cabin grades (16) Detailed cabin specs available at booking.

Name	Supplier code	Type
Concierge Veranda	A1	Balcony
Concierge Veranda	A2	Balcony
Concierge Veranda	A3	Balcony
Veranda Stateroom	B1	Balcony
Veranda Stateroom	B2	Balcony
Inside Stateroom	F	Inside
Inside Stateroom	G	Inside
Deluxe Ocean View Stateroom	C1	Oceanview
Deluxe Ocean View Stateroom	C2	Oceanview
Ocean View Stateroom	D	Oceanview
Solo Oceanview Stateroom	S	Oceanview
Owner's Suite	OS	Suite
Penthouse Suite	PH1	Suite
Penthouse Suite	PH2	Suite
Penthouse Suite	PH3	Suite
Vista Suite	VS	Suite