Rome to Istanbul

7 nights Nov 5, 2026

The Rome to Istanbul is a 7-night Europe cruise aboard Sirena, operated by Oceania Cruises. Departing Civitavecchia, Rome on November 5, 2026, the voyage visits 7 ports. Fares start from $1,960 per person.

Itinerary

Day 2 Nov 6, 2026 Naples 07:00 – 18:00 11.0 hrs ashore Rising behind the wide curve of its bay with brooding Mount Vesuvius and the deep blue sea as a backdrop, Naples, Italy enjoys a magnificent natural setting. It is the third-largest city in Italy after Rome and Milan, and arguably the most colorful and seductive of them all: Splendor and squalor live side by side in 21st-century Naples, and the mix is intoxicating. Cruise to Naples, home to world-class museums and attractions. Naples has something for everyone - superb restaurants, eclectic shopping, a thriving contemporary art scene and an edgy and vibrant street life. But once you’ve had enough of the pounding traffic and jostling crowds while sightseeing in Naples, there are endless opportunities for exploration further afield. The celebrated Roman ruins of Pompeii and Herculaneum, both victims of Vesuvius’ devastating 79 C.E. eruption, lie just south of the city. Explore Naples' history or take a short ride over to the island of Capri on a Naples shore excursion. The delightful town of Sorrento and the magnificent scenery of the Amalfi Coast are also within easy reach, and the dolce vita glamour of Capri—not to mention the healing thermal waters of Ischia—are a short hydrofoil hop from the mainland. Naples cruises offer a perfect mix of cultural and natural attractions. Go to Naples Cruises visiting Naples

Naples photo — Day 2 Nov 6, 2026 Naples 07:00 – 18:00 11.0 hrs ashore Rising behind the wide curve of its bay with brooding Mount Vesuvius and the deep blue sea as a backdrop, Naples, Italy enjoys a magnificent natural setting. It is the third-largest city in Italy after Rome and Milan, and arguably the most colorful and seductive of them all: Splendor and squalor live side by side in 21st-century Naples, and the mix is intoxicating. Cruise to Naples, home to world-class museums and attractions. Naples has something for everyone - superb restaurants, eclectic shopping, a thriving contemporary art scene and an edgy and vibrant street life. But once you’ve had enough of the pounding traffic and jostling crowds while sightseeing in Naples, there are endless opportunities for exploration further afield. The celebrated Roman ruins of Pompeii and Herculaneum, both victims of Vesuvius’ devastating 79 C.E. eruption, lie just south of the city. Explore Naples' history or take a short ride over to the island of Capri on a Naples shore excursion. The delightful town of Sorrento and the magnificent scenery of the Amalfi Coast are also within easy reach, and the dolce vita glamour of Capri—not to mention the healing thermal waters of Ischia—are a short hydrofoil hop from the mainland. Naples cruises offer a perfect mix of cultural and natural attractions. Go to Naples Cruises visiting Naples

Day 3 Nov 7, 2026 Messina, Italy 07:00 – 19:00 12.0 hrs ashore Messina may well be your first sight of Sicily, and – from your MSC holiday cruise ship – it’s a fine one, the glittering town spread up the hillside beyond its sickle-shaped Mediterranean harbour. On a shore excursion you can discover Messina’s most important monument, the Duomo, which epitomizes the city’s phoenix-like ability to re-create itself from the ashes of its last disaster. It’s the reconstruction of a twelfth-century cathedral erected by Roger II, one of a series of great Norman churches of Sicily that include the sumptuous cathedrals of Palermo and Cefalù. The Duomo’s detached campanile, or bell tower, claims to be the largest astronomical clock in the world, and puts on its best show at noon every day, when a bronze lion (Messina’s ancient emblem) unleashes a mighty roar over the city that can be quite alarming if you’re not expecting it! Just back from the Duomo, the truncated section of the twelfth-century Chiesa Annunziata dei Catalani squats below pavement level, and is Messina’s only surviving example of Arab/Norman church-building. When you are cruising the Mediterranean Sea with MSC Cruises, the most obvious excursion from Messina is to the almost too charming hill town of Taormina, spectacularly located on a rocky bluff between the Ionian Sea and the soaring peak of Mount Etna, whose summit with its bleak lava wilderness is one of the most memorable landscapes Italy has to offer. Once the beloved retreat of poets and writers, Taormina is now the most illustrious resort on the entire island, captivating its visitors with its famous ancient theatre, grand hotels and engaging small-town charm. Go to Messina, Italy Cruises visiting Messina, Italy

Messina, Italy photo — Day 3 Nov 7, 2026 Messina, Italy 07:00 – 19:00 12.0 hrs ashore Messina may well be your first sight of Sicily, and – from your MSC holiday cruise ship – it’s a fine one, the glittering town spread up the hillside beyond its sickle-shaped Mediterranean harbour. On a shore excursion you can discover Messina’s most important monument, the Duomo, which epitomizes the city’s phoenix-like ability to re-create itself from the ashes of its last disaster. It’s the reconstruction of a twelfth-century cathedral erected by Roger II, one of a series of great Norman churches of Sicily that include the sumptuous cathedrals of Palermo and Cefalù. The Duomo’s detached campanile, or bell tower, claims to be the largest astronomical clock in the world, and puts on its best show at noon every day, when a bronze lion (Messina’s ancient emblem) unleashes a mighty roar over the city that can be quite alarming if you’re not expecting it! Just back from the Duomo, the truncated section of the twelfth-century Chiesa Annunziata dei Catalani squats below pavement level, and is Messina’s only surviving example of Arab/Norman church-building. When you are cruising the Mediterranean Sea with MSC Cruises, the most obvious excursion from Messina is to the almost too charming hill town of Taormina, spectacularly located on a rocky bluff between the Ionian Sea and the soaring peak of Mount Etna, whose summit with its bleak lava wilderness is one of the most memorable landscapes Italy has to offer. Once the beloved retreat of poets and writers, Taormina is now the most illustrious resort on the entire island, captivating its visitors with its famous ancient theatre, grand hotels and engaging small-town charm. Go to Messina, Italy Cruises visiting Messina, Italy

Day 4 Nov 8, 2026 Malta 07:00 – 19:00 12.0 hrs ashore The UNESCO-protected port of Valletta, the capital of the island of Malta, is one of the must-see stops for every Mediterranean cruise of merit. You can admire this port, constructed in the second half of the 16th century by the Frenchman Jean de la Valette and moulded by the religious and military Order of Saint John of Jerusalem, from your MSC ship even before disembarking. The over 300 monuments rising in little more than half a square kilometre make this a place with one of the greatest density of historical attractions to visit during a cruise, not mentioning other attractions such as its beaches, seaside locales and restaurants. An excursion to the island can start right from its capital, Valletta, which enchants the cruise-goer with its famous Maltese balconies, which decorate the facades of houses in its old quarter. Surrounded by a multitude of churches, which the islanders assure are as many as the days of the year, the St. John’s Co-Cathedral is one of Malta’s biggest tourist attractions. The National Museum of Archaeology, on the other hand, hosts prehistoric artefacts found on the island. By the Grand Harbour, one can visit the underground passages of Auberge de Castille and the beautiful Baracca Gardens, which overlook the harbour; at night, when the city gates would close, its porticoes served as shelter for travellers. To get a taste of the life of Malta’s ancient nobility, visit Casa Rocca Piccola. A 16th century Palazzo now the residence of the 9th Marquis De Piro, it has period furnishings and has a bomb shelter built for protection against bombings during the Second World War. The set of the film Popeye can still be seen from Malta’s largest beach, as well as the Sanctuary of Our Lady of Mellieha with a fresco of the Blessed Virgin Mary with Christ; according to tradition, Saint Luke, who was shipwrecked on the island with Saint Paul, is the author of this Byzantine-style fresco. Go to Malta Cruises visiting Malta

Malta photo — Day 4 Nov 8, 2026 Malta 07:00 – 19:00 12.0 hrs ashore The UNESCO-protected port of Valletta, the capital of the island of Malta, is one of the must-see stops for every Mediterranean cruise of merit. You can admire this port, constructed in the second half of the 16th century by the Frenchman Jean de la Valette and moulded by the religious and military Order of Saint John of Jerusalem, from your MSC ship even before disembarking. The over 300 monuments rising in little more than half a square kilometre make this a place with one of the greatest density of historical attractions to visit during a cruise, not mentioning other attractions such as its beaches, seaside locales and restaurants. An excursion to the island can start right from its capital, Valletta, which enchants the cruise-goer with its famous Maltese balconies, which decorate the facades of houses in its old quarter. Surrounded by a multitude of churches, which the islanders assure are as many as the days of the year, the St. John’s Co-Cathedral is one of Malta’s biggest tourist attractions. The National Museum of Archaeology, on the other hand, hosts prehistoric artefacts found on the island. By the Grand Harbour, one can visit the underground passages of Auberge de Castille and the beautiful Baracca Gardens, which overlook the harbour; at night, when the city gates would close, its porticoes served as shelter for travellers. To get a taste of the life of Malta’s ancient nobility, visit Casa Rocca Piccola. A 16th century Palazzo now the residence of the 9th Marquis De Piro, it has period furnishings and has a bomb shelter built for protection against bombings during the Second World War. The set of the film Popeye can still be seen from Malta’s largest beach, as well as the Sanctuary of Our Lady of Mellieha with a fresco of the Blessed Virgin Mary with Christ; according to tradition, Saint Luke, who was shipwrecked on the island with Saint Paul, is the author of this Byzantine-style fresco. Go to Malta Cruises visiting Malta

Day 6 Nov 10, 2026 Athens (Piraeus), Greece 07:00 – 17:00 10.0 hrs ashore A city of legend, civilisation and enduring culture, Athens is a majestic and magical urban sprawl. Extraordinary elegance and grace combine with grit and graft in Greece's capital, where highways encase ruins from antiquity, and gleaming museums and galleries stand beside concrete sprayed with edgy street art. These contrasts enhance and elevate the wonders of this 2,500-year-old city, however, which can count notable contributions to philosophy, drama and democracy, among its global legacy. Piraeus' giant port and naval base welcome you to the edge of the Athens' urban area. From there it's a simple jaunt to the centre. The majestic ancient citadel of the Acropolis dominates an elevated platform and is a constant presence as you explore the city. The wonderful remains of the columned temple of the Parthenon - which date back to the 5th century BC - stand here, representing the pinnacle of classical architecture. The nearby Acropolis Museum adds context to your visit and frames the broad views from its giant glass windows. Or rise up Mount Lycabettus, to be rewarded with perhaps Athens' best panorama of the Acropolis sitting high over the city on its grand stage. See the marble horseshoe of the Old Olympic Stadium, where the first modern Olympics were held in 1896, for more of the city's enduring legacy. Elsewhere, golden beaches and temples stretch out along the coastline, should you wish to explore a little further afield. Coffee is an art form to the Greeks, and it's an unwritten rule that coffee time must never be rushed. So prepare to settle down for a couple of hours and lose yourself in a good chat. Feeling hungry - try traditional souvlaki made with sauces handed from generation to generation. Go to Athens (Piraeus), Greece Cruises visiting Athens (Piraeus), Greece

Day 8 Nov 12, 2026 Istanbul Arrives 08:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Go to Istanbul Cruises visiting Istanbul

Istanbul photo — Day 8 Nov 12, 2026 Istanbul Arrives 08:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Go to Istanbul Cruises visiting Istanbul

Pricing

Lowest fare we've tracked over the observed 88-day span: $1,610 · range $1,610–$2,040

Lower than 89% of peers This week-long sailing's from-price per night is lower than 89% of comparable sailings.

same cruise line, destination, duration, and departure window · from-price per night · as of Jun 21, 2026

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

Not available

Oceanview

from $1,960

$280 / night

Fare rows

Ocean View Stateroom

Cabin grade

Available

from $1,960

$280 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $2,160

$308 / night

per person · incl. taxes

Ocean View Stateroom

Cabin grade

Available

from $2,449

$349 / night

per person · incl. taxes

Ocean View Stateroom

Cabin grade

Available

from $2,449

$349 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $2,699

$385 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $2,699

$385 / night

per person · incl. taxes

Balcony

from $2,880

$411 / night

Fare rows

Veranda Stateroom

Cabin grade

Available

from $2,880

$411 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $2,920

$417 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $2,960

$422 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $3,000

$428 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $3,160

$451 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $3,599

$514 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $3,599

$514 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $3,649

$521 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $3,649

$521 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $3,699

$528 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $3,699

$528 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $3,749

$535 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $3,749

$535 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $3,949

$564 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $3,949

$564 / night

per person · incl. taxes

Suite

from $3,760

$537 / night

Fare rows

Penthouse Suite

Cabin grade

Available

from $3,760

$537 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $3,880

$554 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $4,000

$571 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $4,699

$671 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $4,699

$671 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $4,849

$692 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $4,849

$692 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $4,999

$714 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $4,999

$714 / night

per person · incl. taxes

Vista Suite

Cabin grade

Available

from $7,599

$1,085 / night

per person · incl. taxes

Vista Suite

Cabin grade

Available

from $7,599

$1,085 / night

per person · incl. taxes

Owner's Suite

Cabin grade

Available

from $8,999

$1,285 / night

per person · incl. taxes

Owner's Suite

Cabin grade

Available

from $8,999

$1,285 / night

per person · incl. taxes

Prices verified Jun 21, 2026

Prices come from third-party data feeds via Oceania Cruises and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

All cabin grades (16) Detailed cabin specs available at booking.

Name	Supplier code	Type
Concierge Veranda	A1	Balcony
Concierge Veranda	A2	Balcony
Concierge Veranda	A3	Balcony
Veranda Stateroom	B1	Balcony
Veranda Stateroom	B2	Balcony
Inside Stateroom	F	Inside
Inside Stateroom	G	Inside
Deluxe Ocean View Stateroom	C1	Oceanview
Deluxe Ocean View Stateroom	C2	Oceanview
Ocean View Stateroom	D	Oceanview
Solo Oceanview Stateroom	S	Oceanview
Owner's Suite	OS	Suite
Penthouse Suite	PH1	Suite
Penthouse Suite	PH2	Suite
Penthouse Suite	PH3	Suite
Vista Suite	VS	Suite