Istanbul to Rome

The Istanbul to Rome is a 10-night Europe cruise aboard Sirena, operated by Oceania Cruises. Departing Istanbul on March 29, 2027, the voyage visits 11 ports. Fares start from $3,299 per person.

Length: 10 nights
Departs: Mar 29, 2027
Returns: Apr 8, 2027
Ports of call: 11

from $3,299

$329 / night per person, incl. taxes & fees

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Itinerary

Day 1 Jul 9, 2027 Istanbul Departs 17:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Istanbul port guide Search cruises visiting Istanbul

Istanbul photo — Day 1 Jul 9, 2027 Istanbul Departs 17:00 A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu. Istanbul port guide Search cruises visiting Istanbul

Day 3 Jul 11, 2027 Kavala, Greece 12:00 – 20:00 8.0 hrs ashore Wind into lively alleys once known as the mecca of tobacco. Climb cobbled streets to Kavala’s old town and the Byzantine walled fortress. Wander the scenic walls to the whitewashed lighthouse for a chance to spot Mount Athos. Watch the amphitheatre put on a show at the top of Panagia, then descend into the Imaret complex of domes. Amble the taverna and bar-filled pedestrianised streets around Agios Nikolaos church and visit the atmospheric old hammam and mosaic memorial before routing to the ancient UNESCO city of Philippi. Refresh in waterfalls at the foot of Mount Pangaion, stroll to village watermills, neo-classical mansions, a celebrated winery and stockpile home-made honey. Float to leafy Thasos for coveted snow-white mined marble, archaeological sites and quaint old stone houses in Kastro. Then relax for Turkish coffee with a side of Greek schnapps in this quietly forgotten corner of Greece. Kavala, Greece port guide Search cruises visiting Kavala, Greece

Kavala, Greece photo — Day 3 Jul 11, 2027 Kavala, Greece 12:00 – 20:00 8.0 hrs ashore Wind into lively alleys once known as the mecca of tobacco. Climb cobbled streets to Kavala’s old town and the Byzantine walled fortress. Wander the scenic walls to the whitewashed lighthouse for a chance to spot Mount Athos. Watch the amphitheatre put on a show at the top of Panagia, then descend into the Imaret complex of domes. Amble the taverna and bar-filled pedestrianised streets around Agios Nikolaos church and visit the atmospheric old hammam and mosaic memorial before routing to the ancient UNESCO city of Philippi. Refresh in waterfalls at the foot of Mount Pangaion, stroll to village watermills, neo-classical mansions, a celebrated winery and stockpile home-made honey. Float to leafy Thasos for coveted snow-white mined marble, archaeological sites and quaint old stone houses in Kastro. Then relax for Turkish coffee with a side of Greek schnapps in this quietly forgotten corner of Greece. Kavala, Greece port guide Search cruises visiting Kavala, Greece

Day 4 Jul 12, 2027 Thessaloniki Departs 19:00 Breeze into a beguiling mix of vintage and modern, awash with a thriving art, culture and history scene. Crowded with museums dedicated to the past plus an extraordinary 15 UNESCO sites – there’s much to learn. Admire ramparts built to last; the impressive Galerius Palace, the beautiful domed multi-serving Rotunda, a bevy of Byzantine churches and the curious 15th century White Tower. Dig deeper into the past to trace pre-historic times at the Archaeological Museum. Rove around Ladadika narrow streets and charming squares that emit a Parisian air, absorb Greek produce in the Market’s holy halls and soak up modern art on the lively waterfront. Raise hairs at Heptapyrgion, take coffee in Aristotelous Square or head out of town to peer at Alexander the Great’s birthplace in Pella and Vergina’s royal tombs. Perfectly poised on the placid Thermaic Gulf, Thessaloniki brings past and present together in remarkable harmony. Thessaloniki port guide Search cruises visiting Thessaloniki

Day 5 Jul 13, 2027 Mykonos 09:00 – 21:00 12.0 hrs ashore Think of a trip to Greece and you will imagine Mykonos. The port of Mykonos, or perhaps it would be more correct to say of Chora, is located on the west coast of the island. The Cyclades islands in the Aegean are wonderful and the beaches are no less marvellous, with the pleasant distinction of being among the most festive in the archipelago. After docking at the port of Mykonos, enjoy the numerous natural coves, beaches and cliffs of this beautiful island. You can enjoy the clean, azure sea of Paradise Beach, while in the evening let yourself be carried away by the rhythm of this cosmopolitan and youthful island. The harbour district, the Kastro, is known as the 'little Venice'. In its alleys, the shops and restaurants alternate with white houses with blue doors and windows. On a trip to Mykonos, take advantage of the stop to go on shore excursions, stroll through the maze of streets and alleys where you can discover the beauty of the architecture and the design of the city. The small white houses with shutters as blue as the sky, the pigeon houses and the numerous small churches of Mykonos will simply enchant you. Mykonos port guide Search cruises visiting Mykonos

Mykonos photo — Day 5 Jul 13, 2027 Mykonos 09:00 – 21:00 12.0 hrs ashore Think of a trip to Greece and you will imagine Mykonos. The port of Mykonos, or perhaps it would be more correct to say of Chora, is located on the west coast of the island. The Cyclades islands in the Aegean are wonderful and the beaches are no less marvellous, with the pleasant distinction of being among the most festive in the archipelago. After docking at the port of Mykonos, enjoy the numerous natural coves, beaches and cliffs of this beautiful island. You can enjoy the clean, azure sea of Paradise Beach, while in the evening let yourself be carried away by the rhythm of this cosmopolitan and youthful island. The harbour district, the Kastro, is known as the 'little Venice'. In its alleys, the shops and restaurants alternate with white houses with blue doors and windows. On a trip to Mykonos, take advantage of the stop to go on shore excursions, stroll through the maze of streets and alleys where you can discover the beauty of the architecture and the design of the city. The small white houses with shutters as blue as the sky, the pigeon houses and the numerous small churches of Mykonos will simply enchant you. Mykonos port guide Search cruises visiting Mykonos

Day 6 Jul 14, 2027 Santorini 09:00 – 18:00 9.0 hrs ashore The guests look for a place on board the ship in good time to enjoy the entrance to the port of Fira, the capital of Santorini. Santorin refers to a Greek archipelago in the south of the Cyclades and at the same time its main island. Here a cliff rises up to 350 m above sea level. Nowhere else in the Aegean Sea is the volcanic origin of the Cyclades so clearly visible as here. Because the impressively high and many kilometers wide rock massif is nothing more than a crater wall. Santorini consists of the main island of the same name, Santorini, which is optionally also called Santorini and Thira, as well as four other Cyclades. With Thirasia, the second largest island and the small uninhabited rock Aspronisi, Santorini forms the geological remains of an outer crater rim. In the middle of the 400 m deep caldera rise the two volcanic islands Palea Kamini and Nea Kamini. They are also uninhabited, apart from the people who receive boat excursions here during the day. On a cruise you will experience this extraordinary island of Greece with the dreamy white houses, black beaches and volcanic stories. Santorini port guide Search cruises visiting Santorini

Santorini photo — Day 6 Jul 14, 2027 Santorini 09:00 – 18:00 9.0 hrs ashore The guests look for a place on board the ship in good time to enjoy the entrance to the port of Fira, the capital of Santorini. Santorin refers to a Greek archipelago in the south of the Cyclades and at the same time its main island. Here a cliff rises up to 350 m above sea level. Nowhere else in the Aegean Sea is the volcanic origin of the Cyclades so clearly visible as here. Because the impressively high and many kilometers wide rock massif is nothing more than a crater wall. Santorini consists of the main island of the same name, Santorini, which is optionally also called Santorini and Thira, as well as four other Cyclades. With Thirasia, the second largest island and the small uninhabited rock Aspronisi, Santorini forms the geological remains of an outer crater rim. In the middle of the 400 m deep caldera rise the two volcanic islands Palea Kamini and Nea Kamini. They are also uninhabited, apart from the people who receive boat excursions here during the day. On a cruise you will experience this extraordinary island of Greece with the dreamy white houses, black beaches and volcanic stories. Santorini port guide Search cruises visiting Santorini

Day 7 Jul 15, 2027 Crete 07:00 – 16:00 9.0 hrs ashore Visit the great Minoan ruins of the Palace of Knossos, famous as the home of the labyrinth where the Minotaur roamed, and the Archaeological Museum housing many superb artifacts from the complex. Explore the stunning mountain-fringed Lassithi plateau with its orchards, 7000 windmills and ancient villages. Shopping: Take home fine reproduction Minoan pottery, a traditional Cretan knife, local embroidery, hand-woven rugs, gold and silver jewelry. Dining: Relax over a dish of hearty moussaka or delicious souvlaki in a taverna, washed down with local wine or beer. Crete port guide Search cruises visiting Crete

Crete photo — Day 7 Jul 15, 2027 Crete 07:00 – 16:00 9.0 hrs ashore Visit the great Minoan ruins of the Palace of Knossos, famous as the home of the labyrinth where the Minotaur roamed, and the Archaeological Museum housing many superb artifacts from the complex. Explore the stunning mountain-fringed Lassithi plateau with its orchards, 7000 windmills and ancient villages. Shopping: Take home fine reproduction Minoan pottery, a traditional Cretan knife, local embroidery, hand-woven rugs, gold and silver jewelry. Dining: Relax over a dish of hearty moussaka or delicious souvlaki in a taverna, washed down with local wine or beer. Crete port guide Search cruises visiting Crete

Day 8 Jul 16, 2027 Olympia (Katakolon), Greece 10:00 – 18:00 8.0 hrs ashore The small Greek port of Katakolon was developed in the 19th century to serve the thriving local trade in currants. Today it is your starting block for Olympia - birthplace of the Olympic Games. A pretty town on the banks of the River Alpheios, Olympia lies only a short drive away from the port and its historic stadium - where the first Olympic torch was lit in 776 BC and is a fascinating site to explore. You can still see the marble starting blocks used by early athletes in the 45,000-seat arena, as well as the ruins of the Temple of Hera and the gigantic Temple of Zeus - its gold and ivory statue of Zeus was one of the Seven Wonders of the ancient world. If you have already visited Olympia, you could spend your day exploring the lush wine country north of Katakolon and sampling the local vintages. Olympia (Katakolon), Greece port guide Search cruises visiting Olympia (Katakolon), Greece

Olympia (Katakolon), Greece photo — Day 8 Jul 16, 2027 Olympia (Katakolon), Greece 10:00 – 18:00 8.0 hrs ashore The small Greek port of Katakolon was developed in the 19th century to serve the thriving local trade in currants. Today it is your starting block for Olympia - birthplace of the Olympic Games. A pretty town on the banks of the River Alpheios, Olympia lies only a short drive away from the port and its historic stadium - where the first Olympic torch was lit in 776 BC and is a fascinating site to explore. You can still see the marble starting blocks used by early athletes in the 45,000-seat arena, as well as the ruins of the Temple of Hera and the gigantic Temple of Zeus - its gold and ivory statue of Zeus was one of the Seven Wonders of the ancient world. If you have already visited Olympia, you could spend your day exploring the lush wine country north of Katakolon and sampling the local vintages. Olympia (Katakolon), Greece port guide Search cruises visiting Olympia (Katakolon), Greece

Day 9 Jul 17, 2027 Taormina 11:00 – 20:00 9.0 hrs ashore On the heights above the Strait of Messina between Sicily and the Italian mainland, the Greeks built a magnificent city, later expanded by the Romans. Its strategic location ensured its continued importance throughout history, and today makes it one of the most attractive and important archaeological sites in Europe. The dominant feature is the large Greco-Roman theater, which boasts striking views of the still-active volcano Mt. Etna. Ruins and remnants are strewn across the hillside setting, inviting visitors to stroll and explore, either on their own or with guides. The town, likewise, is loaded with charm and appeal that invites walking and wonder. Snow-capped Mt. Etna is accessible for visitors when it is not too active. Taormina port guide Search cruises visiting Taormina

Taormina photo — Day 9 Jul 17, 2027 Taormina 11:00 – 20:00 9.0 hrs ashore On the heights above the Strait of Messina between Sicily and the Italian mainland, the Greeks built a magnificent city, later expanded by the Romans. Its strategic location ensured its continued importance throughout history, and today makes it one of the most attractive and important archaeological sites in Europe. The dominant feature is the large Greco-Roman theater, which boasts striking views of the still-active volcano Mt. Etna. Ruins and remnants are strewn across the hillside setting, inviting visitors to stroll and explore, either on their own or with guides. The town, likewise, is loaded with charm and appeal that invites walking and wonder. Snow-capped Mt. Etna is accessible for visitors when it is not too active. Taormina port guide Search cruises visiting Taormina

Day 10 Jul 18, 2027 Amalfi, Italy 08:00 – 18:00 10.0 hrs ashore Spectacular tiers of colour splashed houses cascade down to immeasurably blue seas and hidden coves, along Italy’s premier coastline. Lemon groves and vineyards bask in the country’s generous southern sun, running alongside dramatic mountain precipices, and dazzlingly romantic fishing villages. The Amalfi Coast is rightly celebrated as a treasure of Italy, and you can enjoy the true scale of it, and the feel of the salty sea breeze in your hair, as you hike the Path of the Gods - where some of the best heavenly views of the beautiful beaches and improbably teetering villages open up below you. The call of beachside bliss is never far away, and descending down to Duoglio Beach is a mesmerising introduction to the coastline’s jagged rock setting and crystalline waters. A dramatic ramp of steps rears up to Amalfi's distinctive black and white striped, Moorish-influenced cathedral, which stands at the heart of the town. Inside, tranquillity awaits amid the arches and columns of the Cloister of Paradise. Chattering piazzas, where ice cubes clink in glowing spritz cocktails, and strong espressos are savoured, hum with life nearby. Enjoy plates of shellfish tangled spaghetti or spicy pezzente salami in your choice of the Amalfi Coast’s celebrated restaurants, before tasting locally-squeezed limoncello - the perfect denouement to any meal here. Grand villas, spectacular restaurants and well-heeled visitors have long given Amalfi a reputation for refined luxury, but things haven’t always been so peaceful here. In the 10th and 11th centuries, Amalfi was an independent maritime republic, and the Municipal Museum of Amalfi is the place to learn of the region’s rise to global trading prominence, and the devastating tsunami that washed it all away in 1343. Amalfi, Italy port guide Search cruises visiting Amalfi, Italy

Day 11 Jul 19, 2027 Civitavecchia, Rome Arrives 07:00 All roads lead to Rome, and with good reason - this city is one of the world’s most thrilling, offering unmatched history along every street. An evocative, inspiring and utterly artistic capital of unrivalled cultural impact, Rome is a city of back-to-back landmarks, which will take you on an exhilarating journey through the ages. This may be one of the world’s oldest cities, but it’s well and truly lived in. The ruins are punctuated with murmuring cafes, and the outdoor seating of restaurants sprawls out across piazzas, enticing you to sample tangles of creamy pasta and crispy pizzas. Rome’s incredible Roman Forum is littered with the ruins of its ancient administrations, which have stood firm for 2,000 years, since the times when the area was the centre of the Western world. Few sites are more simultaneously beautiful and haunting than that of the storied Colosseum, which looms deep into Rome’s rich blue sky. Take a tour to learn details of the grisly goings-on within. The best way to experience Rome is to wander its streets, gelato in hand. There is a lot to see here - whether it’s the domed spectacle of the Pantheon, or the elaborate flowing waters and artistry of the Trevi Fountain. Vatican City is an astonishing, colossal display of Catholic grandeur, while the Spanish Steps – crowned by the Trinità dei Monti church – offer a beautiful spot to gather and soak up the lively atmosphere of this humming city. With so much on the to-do list, you’ll relish the breaks you take, enjoying simple pleasures like a strong espresso, or fresh pasta with tomato sauce and ripped basil. Civitavecchia, Rome port guide Search cruises visiting Civitavecchia, Rome

Pricing

Lowest fare we've tracked over the observed 91-day span: $3,299 · range $3,299–$3,299

Lower than 82% of peers This longer-duration sailing's from-price per night is lower than 82% of comparable sailings.

same cruise line, destination, duration, and departure window · from-price per night · as of Jun 23, 2026

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $3,299

$329 / night

Fare rows

Inside Stateroom

Cabin grade

Available

from $3,299

$329 / night

per person · incl. taxes

Inside Stateroom

Cabin grade

Available

from $3,399

$339 / night

per person · incl. taxes

Oceanview

from $3,749

$374 / night

Fare rows

Ocean View Stateroom

Cabin grade

Available

from $3,749

$374 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $4,049

$404 / night

per person · incl. taxes

Deluxe Ocean View Stateroom

Cabin grade

Available

from $4,099

$409 / night

per person · incl. taxes

Solo Oceanview Stateroom

Cabin grade

Available

from $6,399

$639 / night

per person · incl. taxes

Balcony

from $5,399

$539 / night

Fare rows

Veranda Stateroom

Cabin grade

Available

from $5,399

$539 / night

per person · incl. taxes

Veranda Stateroom

Cabin grade

Available

from $5,549

$554 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $5,799

$579 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $5,949

$594 / night

per person · incl. taxes

Concierge Veranda

Cabin grade

Available

from $6,099

$609 / night

per person · incl. taxes

Suite

from $7,499

$749 / night

Fare rows

Penthouse Suite

Cabin grade

Available

from $7,499

$749 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $7,699

$769 / night

per person · incl. taxes

Penthouse Suite

Cabin grade

Available

from $7,899

$789 / night

per person · incl. taxes

Vista Suite

Cabin grade

Available

from $12,499

$1,249 / night

per person · incl. taxes

Owner's Suite

Cabin grade

Available

from $15,299

$1,529 / night

per person · incl. taxes

Prices verified Jun 21, 2026

Prices come from third-party data feeds via Oceania Cruises and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

Show all 16 cabin grades

Name	Supplier code	Type
Concierge Veranda	A1	Balcony
Concierge Veranda	A2	Balcony
Concierge Veranda	A3	Balcony
Veranda Stateroom	B1	Balcony
Veranda Stateroom	B2	Balcony
Inside Stateroom	F	Inside
Inside Stateroom	G	Inside
Deluxe Ocean View Stateroom	C1	Oceanview
Deluxe Ocean View Stateroom	C2	Oceanview
Ocean View Stateroom	D	Oceanview
Solo Oceanview Stateroom	S	Oceanview
Owner's Suite	OS	Suite
Penthouse Suite	PH1	Suite
Penthouse Suite	PH2	Suite
Penthouse Suite	PH3	Suite
Vista Suite	VS	Suite