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Civitavecchia, Rome

21 nights · Eastern Mediterranean

21-night Eastern Mediterranean cruise: Civitavecchia, Rome to Istanbul on Rotterdam

The 21-Day Around Italy's Boot: Greek Isles & Venice Overnight is a 21-night Eastern Mediterranean cruise aboard Rotterdam, operated by Holland America Line. Departing Civitavecchia, Rome on November 11, 2028 and arriving in Istanbul on December 2, 2028, the voyage visits 15 ports including Naples, Messina, Italy, Kotor. Fares start from $4,434 per person.

Length
21 nights
Departs
Nov 11, 2028
Returns
Dec 2, 2028
Ports of call
15
Days at sea
5

Voyage code Y878B

from $4,434 pp

via CruiseDirect

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Why this route stands out

A closer look at the journey

Fixed editorial images from the places on this itinerary. They stay stable each time you return to this sailing.

Civitavecchia, Rome

All roads lead to Rome, and with good reason - this city is one of the world’s most thrilling, offering unmatched history along every street. An evocative, inspiring and utterly artistic capital of unrivalled cultural impact, Rome is a city of back-to-back landmarks, which will take you on an exhilarating journey through the ages. This may be one of the world’s oldest cities, but it’s well and truly lived in. The ruins are punctuated with murmuring cafes, and the outdoor seating of restaurants sprawls out across piazzas, enticing you to sample tangles of creamy pasta and crispy pizzas. Rome’s incredible Roman Forum is littered with the ruins of its ancient administrations, which have stood firm for 2,000 years, since the times when the area was the centre of the Western world. Few sites are more simultaneously beautiful and haunting than that of the storied Colosseum, which looms deep into Rome’s rich blue sky. Take a tour to learn details of the grisly goings-on within. The best way to experience Rome is to wander its streets, gelato in hand. There is a lot to see here - whether it’s the domed spectacle of the Pantheon, or the elaborate flowing waters and artistry of the Trevi Fountain. Vatican City is an astonishing, colossal display of Catholic grandeur, while the Spanish Steps – crowned by the Trinità dei Monti church – offer a beautiful spot to gather and soak up the lively atmosphere of this humming city. With so much on the to-do list, you’ll relish the breaks you take, enjoying simple pleasures like a strong espresso, or fresh pasta with tomato sauce and ripped basil.

Naples

Rising behind the wide curve of its bay with brooding Mount Vesuvius and the deep blue sea as a backdrop, Naples, Italy enjoys a magnificent natural setting. It is the third-largest city in Italy after Rome and Milan, and arguably the most colorful and seductive of them all: Splendor and squalor live side by side in 21st-century Naples, and the mix is intoxicating. Cruise to Naples, home to world-class museums and attractions. Naples has something for everyone - superb restaurants, eclectic shopping, a thriving contemporary art scene and an edgy and vibrant street life. But once you’ve had enough of the pounding traffic and jostling crowds while sightseeing in Naples, there are endless opportunities for exploration further afield. The celebrated Roman ruins of Pompeii and Herculaneum, both victims of Vesuvius’ devastating 79 C.E. eruption, lie just south of the city. Explore Naples' history or take a short ride over to the island of Capri on a Naples shore excursion. The delightful town of Sorrento and the magnificent scenery of the Amalfi Coast are also within easy reach, and the dolce vita glamour of Capri—not to mention the healing thermal waters of Ischia—are a short hydrofoil hop from the mainland. Naples cruises offer a perfect mix of cultural and natural attractions.

Messina, Italy

Messina may well be your first sight of Sicily, and – from your MSC holiday cruise ship – it’s a fine one, the glittering town spread up the hillside beyond its sickle-shaped Mediterranean harbour. On a shore excursion you can discover Messina’s most important monument, the Duomo, which epitomizes the city’s phoenix-like ability to re-create itself from the ashes of its last disaster. It’s the reconstruction of a twelfth-century cathedral erected by Roger II, one of a series of great Norman churches of Sicily that include the sumptuous cathedrals of Palermo and Cefalù. The Duomo’s detached campanile, or bell tower, claims to be the largest astronomical clock in the world, and puts on its best show at noon every day, when a bronze lion (Messina’s ancient emblem) unleashes a mighty roar over the city that can be quite alarming if you’re not expecting it! Just back from the Duomo, the truncated section of the twelfth-century Chiesa Annunziata dei Catalani squats below pavement level, and is Messina’s only surviving example of Arab/Norman church-building. When you are cruising the Mediterranean Sea with MSC Cruises, the most obvious excursion from Messina is to the almost too charming hill town of Taormina, spectacularly located on a rocky bluff between the Ionian Sea and the soaring peak of Mount Etna, whose summit with its bleak lava wilderness is one of the most memorable landscapes Italy has to offer. Once the beloved retreat of poets and writers, Taormina is now the most illustrious resort on the entire island, captivating its visitors with its famous ancient theatre, grand hotels and engaging small-town charm.

Price tracking

Today’s fare, in context

Price history

All
Fare details

Fare details

Per person · taxes & fees included
Current fares
Verified 15 hours ago
Inside
$4,434
Oceanview
$5,234
Balcony
$5,684
Suite
$6,834
Tracked range
5 days
Price history by cabin type
CabinCurrentLowestHighest
Inside $4,434 $4,434 on Aug 25 $4,434 on Aug 25
Oceanview $5,234 $5,234 on Aug 25 $5,234 on Aug 25
Balcony $5,684 $5,684 on Aug 25 $5,684 on Aug 25
Suite $6,834 $6,834 on Aug 25 $6,834 on Aug 25
Cabin grades
35 total
Verandah StateroomBalcony · V
Verandah StateroomBalcony · VA
Verandah StateroomBalcony · VB
Verandah StateroomBalcony · VC
Verandah StateroomBalcony · VD
Verandah StateroomBalcony · VE
Verandah StateroomBalcony · VF
Partially Obstructed VerandahBalcony · VH
Verandah Spa StateroomBalcony · VQ
Verandah StateroomBalcony · VS
Standard Interior StateroomInside · I
Spa Interior StateroomInside · IQ
Standard Interior StateroomInside · J
Standard Interior StateroomInside · K
Standard Interior StateroomInside · L
Standard Interior StateroomInside · N
Large Ocean View StateroomOceanview · C
Spa Large Ocean View StateroomOceanview · CQ
Large Ocean View StateroomOceanview · D
Large Ocean View StateroomOceanview · E
Large Ocean View StateroomOceanview · F
Family Ocean View StateroomOceanview · FA
Family Ocean View StateroomOceanview · FB
Single Ocean View StateroomOceanview · OO
Vista SuiteSuite · A
Aft - Vista SuiteSuite · AS
Vista SuiteSuite · B
Vista SuiteSuite · BC
Pinnacle SuiteSuite · PS
Neptune SuiteSuite · SA
Neptune SuiteSuite · SB
Neptune SuiteSuite · SC
Spa Neptune SuiteSuite · SQ
Signature SuiteSuite · SS
Signature SuiteSuite · SY

○ = last seen (sold out or delisted). · Verified 15 hours ago.

Lowest fares with no residency, age, or service requirement — verify eligibility at booking. How our pricing works

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Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $4,434

$211 / night

Fare rows

Standard Interior Stateroom

Cabin grade

Available

from $4,434

$211 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $4,494

$214 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $4,524

$215 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $4,554

$216 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $4,584

$218 / night

per person · incl. taxes & fees

Spa Interior Stateroom

Cabin grade

Available

from $4,614

$219 / night

per person · incl. taxes & fees

Oceanview

from $5,234

$249 / night

Fare rows

Large Ocean View Stateroom

Cabin grade

Available

from $5,234

$249 / night

per person · incl. taxes & fees

Large Ocean View Stateroom

Cabin grade

Available

from $5,324

$253 / night

per person · incl. taxes & fees

Large Ocean View Stateroom

Cabin grade

Available

from $5,394

$256 / night

per person · incl. taxes & fees

Large Ocean View Stateroom

Cabin grade

Available

from $5,464

$260 / night

per person · incl. taxes & fees

Family Ocean View Stateroom

Cabin grade

Available

from $5,604

$266 / night

per person · incl. taxes & fees

Family Ocean View Stateroom

Cabin grade

Available

from $5,674

$270 / night

per person · incl. taxes & fees

Single Ocean View Stateroom

Cabin grade

Available

from $8,008

$381 / night

per person · incl. taxes & fees

Balcony

from $5,684

$270 / night

Fare rows

Partially Obstructed Verandah

Cabin grade

Available

from $5,684

$270 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $5,984

$284 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,134

$292 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,254

$297 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,374

$303 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,494

$309 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,614

$314 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,734

$320 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $6,854

$326 / night

per person · incl. taxes & fees

Verandah Spa Stateroom

Cabin grade

Available

from $6,974

$332 / night

per person · incl. taxes & fees

Suite

from $6,834

$325 / night

Fare rows

Vista Suite

Cabin grade

Available

from $6,834

$325 / night

per person · incl. taxes & fees

Vista Suite

Cabin grade

Available

from $7,104

$338 / night

per person · incl. taxes & fees

Vista Suite

Cabin grade

Available

from $7,374

$351 / night

per person · incl. taxes & fees

Aft - Vista Suite

Cabin grade

Available

from $7,644

$364 / night

per person · incl. taxes & fees

Signature Suite

Cabin grade

Available

from $8,434

$401 / night

per person · incl. taxes & fees

Neptune Suite

Cabin grade

Available

from $10,084

$480 / night

per person · incl. taxes & fees

Neptune Suite

Cabin grade

Available

from $10,894

$518 / night

per person · incl. taxes & fees

Neptune Suite

Cabin grade

Available

from $11,704

$557 / night

per person · incl. taxes & fees

Prices verified Aug 28, 2026

Prices come from third-party data feeds via Holland America Line and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

Lowest fares with no residency, age, or service requirement — verify eligibility at booking. How our pricing works

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The journey

21 nights, in order

Follow the entire sailing from its first day to its last, with the route and schedule in one view.

Civitavecchia, Rome

Day 1 Nov 11, 2028

Civitavecchia, Rome

All roads lead to Rome, and with good reason - this city is one of the world’s most thrilling, offering unmatched history along every street.

Explore Civitavecchia, Rome

Day by day

The full itinerary

22 scheduled calls
Rotterdam

Your ship

Rotterdam

In honor of some of the most memorable ships in Holland America Line's history, our third Pinnacle-class ship (and new flagship) will be named Rotterdam. This new addition to our fleet will fill your journey with a rhythm all its own, putting music front and center, creating the soundtrack to the discoveries you make every day. At the heart of it all is Music Walk: an exclusive collection of five venues featuring live music and electrifying performances from accomplished musicians, dancers and artists every night. Rotterdam hits all the right notes: exquisite dining experiences, enhanced staterooms and suites, the finest service at sea and craftsmanship that reflects nearly 150 years of seafaring expertise. The result is a ship that moves you — from the start of your first day to the end of each perfect night.

5★ 781 GT 2,668 Passengers Built 2021
Rotterdam ship guide Search cruises on Rotterdam

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Advanced options Cabins & price targets

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at or below $
at or below $

from $4,434 pp

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Book direct with Holland America Line we may earn a commission