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21-night Mediterranean cruise: Civitavecchia, Rome to Athens (Piraeus), Greece on Oosterdam

The 21-Day Adriatic Antiquities: Italy, Croatia & Greek Isles is a 21-night Mediterranean cruise aboard Oosterdam, operated by Holland America Line. Departing Civitavecchia, Rome on September 11, 2027 and arriving in Athens (Piraeus), Greece on October 2, 2027, the voyage visits 15 ports including Naples, Palermo, Messina, Italy. Fares start from $6,139 per person.

Length
21 nights
Departs
Sep 11, 2027
Returns
Oct 2, 2027
Ports of call
15
Days at sea
7

Voyage code O757A

Civitavecchia, Rome

21 nights · Mediterranean

from $6,139 pp

via CruiseDirect

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Why this route stands out

A closer look at the journey

Civitavecchia, Rome

All roads lead to Rome, and with good reason - this city is one of the world’s most thrilling, offering unmatched history along every street. An evocative, inspiring and utterly artistic capital of unrivalled cultural impact, Rome is a city of back-to-back landmarks, which will take you on an exhilarating journey through the ages. This may be one of the world’s oldest cities, but it’s well and truly lived in. The ruins are punctuated with murmuring cafes, and the outdoor seating of restaurants sprawls out across piazzas, enticing you to sample tangles of creamy pasta and crispy pizzas. Rome’s incredible Roman Forum is littered with the ruins of its ancient administrations, which have stood firm for 2,000 years, since the times when the area was the centre of the Western world. Few sites are more simultaneously beautiful and haunting than that of the storied Colosseum, which looms deep into Rome’s rich blue sky. Take a tour to learn details of the grisly goings-on within. The best way to experience Rome is to wander its streets, gelato in hand. There is a lot to see here - whether it’s the domed spectacle of the Pantheon, or the elaborate flowing waters and artistry of the Trevi Fountain. Vatican City is an astonishing, colossal display of Catholic grandeur, while the Spanish Steps – crowned by the Trinità dei Monti church – offer a beautiful spot to gather and soak up the lively atmosphere of this humming city. With so much on the to-do list, you’ll relish the breaks you take, enjoying simple pleasures like a strong espresso, or fresh pasta with tomato sauce and ripped basil.

Naples

Rising behind the wide curve of its bay with brooding Mount Vesuvius and the deep blue sea as a backdrop, Naples, Italy enjoys a magnificent natural setting. It is the third-largest city in Italy after Rome and Milan, and arguably the most colorful and seductive of them all: Splendor and squalor live side by side in 21st-century Naples, and the mix is intoxicating. Cruise to Naples, home to world-class museums and attractions. Naples has something for everyone - superb restaurants, eclectic shopping, a thriving contemporary art scene and an edgy and vibrant street life. But once you’ve had enough of the pounding traffic and jostling crowds while sightseeing in Naples, there are endless opportunities for exploration further afield. The celebrated Roman ruins of Pompeii and Herculaneum, both victims of Vesuvius’ devastating 79 C.E. eruption, lie just south of the city. Explore Naples' history or take a short ride over to the island of Capri on a Naples shore excursion. The delightful town of Sorrento and the magnificent scenery of the Amalfi Coast are also within easy reach, and the dolce vita glamour of Capri—not to mention the healing thermal waters of Ischia—are a short hydrofoil hop from the mainland. Naples cruises offer a perfect mix of cultural and natural attractions.

Palermo

The capital of Sicily is situated on a crescent-shaped bay on the island's north coast. Once the intellectual capital of southern Europe, Palermo has always been at the crossroads of civilization. Due to its favourable location, Sicily's most interesting city has attracted almost every people and culture touching the Mediterranean world. Its most unique characteristic is a harmonious blend of Arab-Norman cultures mixed with Byzantine and Jewish elements, which created some unforgettable and resplendent works of art. Phoenician traders first colonized Palermo in the 6th-century BC, but it was the Carthaginians, who built the important fortress here that caught the covetous eye of the Romans. After the first Punic War, the Romans took control of the city in the 3rd-century BC. Following several invasions by the Vandals, Sicily was settled by Arabs, who made the country an emirate and Palermo a showpiece capital that rivalled in splendour both Cordoba and Cairo. The city became a magical place of palaces and mosques, minarets and palm trees. In the 11th-century Palermo was conquered by the Norman ruler, Roger de Hauteville. During the Normans' hundred-year occupation, the city experienced a remarkable period of enlightenment and a flourishing of the arts. Counting a population of more than 300,000, Palermo became the centre of Norman rule and one of the most important trading centres between East and West. Eventually, Palermo was incorporated into the “Kingdom of the Two Sicilies” under the Swabian ruler Frederick II, known as the Holy Roman Emperor. After the bloody Sicilian Vespers uprising in 1282, the Spanish took control and brought the Inquisition to Palermo. Some historians believe that the nature of the Inquisition helped foster the protective secret societies that eventually evolved into the Mafia. Today, visitors can still experience the legacy of Palermo's rich past. Great Arab-Norman buildings include the Cappella Palatina, La Martorana, San Giovanni degli Eremiti and, a few miles outside the city, the Cathedral of Monreale. Palermo's bustling streets and animated markets give the town an Oriental feel. The Quattro Canti, or Four Corners, is the monumental crossroads laid out in 1608-1620 at the central intersection of the four longest and straightest streets of the city. North of Piazza Castelnuovo lie the avenues of the new city. Most sights are scattered along three major streets: Corso Vittorio Emanuele, Via Maqueda and Via Roma. A vigorous metropolis with a strong historical profile, Palermo is packed with interesting sights, which make it an enriching and enjoyable place to explore.

Price tracking

Today’s fare, in context

Price history

Cheaper than 74%
30 days
Fare details

Fare details

Per person · taxes & fees included
Current fares
Verified 3 hours ago
Inside
$6,139
Oceanview
$6,469
Balcony
$9,359
Tracked range
160 days
Price history by cabin type
CabinCurrentLowestHighest
Inside $6,139 $5,884 on Mar 30 $6,139 on Aug 7
Oceanview $6,469 $4,999 on Aug 24 $6,469 on Aug 7
Balcony $9,359 $7,649 on Aug 16 $9,359 on Aug 30
Suite $11,119 $10,214 on Mar 30 $11,119 on Aug 1
Cabin grades
29 total
Verandah StateroomBalcony · VA
Verandah StateroomBalcony · VB
Verandah StateroomBalcony · VC
Verandah StateroomBalcony · VD
Verandah StateroomBalcony · VE
Verandah StateroomBalcony · VF
Verandah StateroomBalcony · VH
Large/Standard Inside StateroomInside · I
Large Interior StateroomInside · J
Large/Standard Inside StateroomInside · K
Standard Interior StateroomInside · L
Standard Interior StateroomInside · M
Large/Standard Inside StateroomInside · MM
Standard Interior StateroomInside · N
Large Ocean view StateroomOceanview · C
Large Ocean view StateroomOceanview · D
Large Ocean view StateroomOceanview · DD
Large Ocean view StateroomOceanview · E
Large Ocean view StateroomOceanview · F
Large Ocean view Stateroom (Partial Sea View)Oceanview · G
Large Ocean view Stateroom (Fully Obstructed View)Oceanview · H
Large Ocean view Stateroom (Fully Obstructed View)Oceanview · HH
Pinnacle SuiteSuite · PS
Neptune SuiteSuite · SA
Neptune SuiteSuite · SB
Neptune SuiteSuite · SC
Signature SuiteSuite · SS
Signature SuiteSuite · SY
Signature SuiteSuite · SZ

○ = last seen (sold out or delisted). · Verified 3 hours ago.

Lowest fares with no residency, age, or service requirement — verify eligibility at booking. How our pricing works

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $6,139

$292 / night

Fare rows

Standard Interior Stateroom

Cabin grade

Available

from $6,139

$292 / night

per person · incl. taxes & fees

Large/Standard Inside Stateroom

Cabin grade

Available

from $6,199

$295 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $6,229

$296 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $6,259

$298 / night

per person · incl. taxes & fees

Large/Standard Inside Stateroom

Cabin grade

Available

from $6,289

$299 / night

per person · incl. taxes & fees

Oceanview

from $6,469

$308 / night

Fare rows

Large Ocean view Stateroom (Fully Obstructed View)

Cabin grade

Available

from $6,469

$308 / night

per person · incl. taxes & fees

Balcony

from $9,359

$445 / night

Fare rows

Verandah Stateroom

Cabin grade

Available

from $9,359

$445 / night

per person · incl. taxes & fees

Suite

Not available

Prices verified Sep 5, 2026

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The journey

21 nights, in order

Civitavecchia, Rome

Day 1 Sep 11, 2027

Civitavecchia, Rome

All roads lead to Rome, and with good reason - this city is one of the world’s most thrilling, offering unmatched history along every street.

Explore Civitavecchia, Rome

Day by day

The full itinerary

25 scheduled calls
Oosterdam

Your ship

Oosterdam

Oosterdam, a Vista-class ship, recently emerged from dry dock with exciting updates—including completely refreshed suites and new lounge, dining and entertainment venues, such as Music Walk, with Lincoln Center Stage, B.B. King’s Blues Club and Billboard Onboard. Guests can choose from among delectable specialty restaurants, hone culinary skills with EXC Port to Table and thrill to BBC Earth Experiences.

5★ 82,305 GT 1,916 Passengers Built 2003
Oosterdam ship guide Search cruises on Oosterdam

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from $6,139 pp

via CruiseDirect

Book with CruiseDirect

Book direct with Holland America Line we may earn a commission