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21-night Adriatic cruise: Athens (Piraeus), Greece to Barcelona on Oosterdam

The 21-Day Greek Isles with Istanbul, Dubrovnik, Italy & Spain is a 21-night Adriatic cruise aboard Oosterdam, operated by Holland America Line. Departing Athens (Piraeus), Greece on May 4, 2027 and arriving in Barcelona on May 25, 2027, the voyage visits 16 ports including Kusadasi, Istanbul, Mykonos. Fares start from $5,444 per person.

Length
21 nights
Departs
May 4, 2027
Returns
May 25, 2027
Ports of call
16
Days at sea
5

Voyage code O725A

Athens (Piraeus), Greece

21 nights · Adriatic

from $5,444 pp

via CruiseDirect

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Why this route stands out

A closer look at the journey

Athens (Piraeus), Greece

A city of legend, civilisation and enduring culture, Athens is a majestic and magical urban sprawl. Extraordinary elegance and grace combine with grit and graft in Greece's capital, where highways encase ruins from antiquity, and gleaming museums and galleries stand beside concrete sprayed with edgy street art. These contrasts enhance and elevate the wonders of this 2,500-year-old city, however, which can count notable contributions to philosophy, drama and democracy, among its global legacy. Piraeus' giant port and naval base welcome you to the edge of the Athens' urban area. From there it's a simple jaunt to the centre. The majestic ancient citadel of the Acropolis dominates an elevated platform and is a constant presence as you explore the city. The wonderful remains of the columned temple of the Parthenon - which date back to the 5th century BC - stand here, representing the pinnacle of classical architecture. The nearby Acropolis Museum adds context to your visit and frames the broad views from its giant glass windows. Or rise up Mount Lycabettus, to be rewarded with perhaps Athens' best panorama of the Acropolis sitting high over the city on its grand stage. See the marble horseshoe of the Old Olympic Stadium, where the first modern Olympics were held in 1896, for more of the city's enduring legacy. Elsewhere, golden beaches and temples stretch out along the coastline, should you wish to explore a little further afield. Coffee is an art form to the Greeks, and it's an unwritten rule that coffee time must never be rushed. So prepare to settle down for a couple of hours and lose yourself in a good chat. Feeling hungry - try traditional souvlaki made with sauces handed from generation to generation.

Kusadasi

Kusadasi in Turkey is the gateway to one of the most legendary cities of the ancient world: Ephesus. St. Paul preached in its Great Theater, while the facade of the Celsus Library survives as a testament to the city’s role as a center of learning and culture. Not far from Ephesus, the Temple of Artemis (also known as the Temple of Diana), one of the Seven Wonders of the ancient world, once stood, drawing pilgrims from around the Mediterranean. While it no longer stands, it is possible to walk amongst its foundations and the remains of its towering columns. Other historic sites can also be found nearby: The House of Mary is believed to be the home of Jesus’s mother at the end of her life, and the Basilica of St. John, constructed in the 6th century, marks the location of his tomb. (Like Mary, he spent his final years in Ephesus.) Nearby, the Selcuk fortress reflects the period of Byzantine and Ottoman control of the region. From ancient wonders to holy sites, there are few ports in the Mediterranean as magical as Kusadasi, and a day here is a day spent in the company of some of antiquity's greatest figures.

Istanbul

A shore excursion on your MSC Mediterranean cruise can be the opportunity to discover İstanbul which stands astride two continents, Europe and Asia. As if its spectacular geographical location were not enough, it can also boast of being the only city to have played capital to consecutive Christian and Islamic empires, a role that has shaped the region’s history for more than 2500 years and bequeathed to İstanbul a staggering wealth of attractions. Most cruise visitors spend all their holiday time in Sultanahmet, home to İstanbul’s main sightseeing attractions: the church of Aya Sofya, the greatest legacy of the Byzantine Empire; the Topkapı Palace, heart of the Ottoman Empire; and the massive Sultanahmet Camii (Blue Mosque). Here also are the ancient Hippodrome, the Museum of Turkish and Islamic Art (housed in the former Palace of İbrahim Paşa), the eerily lit Yerebatan Sarnıcı, a fascinating Byzantine underground cistern, and the Grand Bazaar (Kapalı Çarşı), the largest covered bazaar in the world. The monumental architecture, attractive parks and gardens, street-side cafés, and the benefits of a relatively traffic-free main road combine to make this area pleasant for both sightseeing and staying on an MSC Mediterranean cruise excursion. İstanbul’s Ottoman-era Grand Bazaar gets more than its fair share of souvenir-hungry visitors. The area around it, however, is relatively little explored, which is a shame as it holds some very worthwhile attractions, from the historic Cembirlitaş Hamamı, one of the best Turkish baths in the country, to the city’s very best mosque, the hilltop Süleymaniye Camii. The best single reason to head across to the Asian shore of the city is to experience a Bosphorus cruise. The views from the Bosphorus are superb, with domes and minarets dominating the skyline of the Old City, and skyscrapers the business districts beyond Beyoğlu.

Price tracking

Today’s fare, in context

Price history

Cheaper than 93%
30 days
Fare details

Fare details

Per person · taxes & fees included
Current fares
Verified 14 hours ago
Inside
$5,444
Oceanview
$6,114
Balcony
$7,924
Suite
$10,304
Tracked range
162 days
Price history by cabin type
CabinCurrentLowestHighest
Inside $5,444 $5,389 on Mar 25 $5,494 on Aug 1
Oceanview $6,114 $5,769 on Mar 25 $6,114 on Aug 29
Balcony $7,924 $7,059 on Mar 25 $7,924 on Aug 29
Suite $10,304 $9,209 on Mar 25 $10,304 on Aug 29
Cabin grades
29 total
Verandah StateroomBalcony · VA
Verandah StateroomBalcony · VB
Verandah StateroomBalcony · VC
Verandah StateroomBalcony · VD
Verandah StateroomBalcony · VE
Verandah StateroomBalcony · VF
Verandah StateroomBalcony · VH
Large/Standard Inside StateroomInside · I
Large Interior StateroomInside · J
Large/Standard Inside StateroomInside · K
Standard Interior StateroomInside · L
Standard Interior StateroomInside · M
Large/Standard Inside StateroomInside · MM
Standard Interior StateroomInside · N
Large Ocean view StateroomOceanview · C
Large Ocean view StateroomOceanview · D
Large Ocean view StateroomOceanview · DD
Large Ocean view StateroomOceanview · E
Large Ocean view StateroomOceanview · F
Large Ocean view Stateroom (Partial Sea View)Oceanview · G
Large Ocean view Stateroom (Fully Obstructed View)Oceanview · H
Large Ocean view Stateroom (Fully Obstructed View)Oceanview · HH
Pinnacle SuiteSuite · PS
Neptune SuiteSuite · SA
Neptune SuiteSuite · SB
Neptune SuiteSuite · SC
Signature SuiteSuite · SS
Signature SuiteSuite · SY
Signature SuiteSuite · SZ

○ = last seen (sold out or delisted). · Verified 14 hours ago.

Lowest fares with no residency, age, or service requirement — verify eligibility at booking. How our pricing works

Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $5,444

$259 / night

Fare rows

Standard Interior Stateroom

Cabin grade

Available

from $5,444

$259 / night

per person · incl. taxes & fees

Large/Standard Inside Stateroom

Cabin grade

Available

from $5,504

$262 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $5,534

$263 / night

per person · incl. taxes & fees

Standard Interior Stateroom

Cabin grade

Available

from $5,564

$264 / night

per person · incl. taxes & fees

Large/Standard Inside Stateroom

Cabin grade

Available

from $5,594

$266 / night

per person · incl. taxes & fees

Large Interior Stateroom

Cabin grade

Available

from $5,624

$267 / night

per person · incl. taxes & fees

Large/Standard Inside Stateroom

Cabin grade

Available

from $5,654

$269 / night

per person · incl. taxes & fees

Oceanview

from $6,114

$291 / night

Fare rows

Large Ocean view Stateroom (Fully Obstructed View)

Cabin grade

Available

from $6,114

$291 / night

per person · incl. taxes & fees

Large Ocean view Stateroom (Fully Obstructed View)

Cabin grade

Available

from $6,204

$295 / night

per person · incl. taxes & fees

Large Ocean view Stateroom (Partial Sea View)

Cabin grade

Available

from $6,274

$298 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $6,394

$304 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $6,464

$307 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $6,534

$311 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $6,604

$314 / night

per person · incl. taxes & fees

Large Ocean view Stateroom

Cabin grade

Available

from $6,674

$317 / night

per person · incl. taxes & fees

Balcony

from $7,924

$377 / night

Fare rows

Verandah Stateroom

Cabin grade

Available

from $7,924

$377 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $8,314

$395 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $8,434

$401 / night

per person · incl. taxes & fees

Verandah Stateroom

Cabin grade

Available

from $8,554

$407 / night

per person · incl. taxes & fees

Suite

from $10,304

$490 / night

Fare rows

Signature Suite

Cabin grade

Available

from $10,304

$490 / night

per person · incl. taxes & fees

Prices verified Sep 1, 2026

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The journey

21 nights, in order

Athens (Piraeus), Greece

Day 1 May 4, 2027

Athens (Piraeus), Greece

A city of legend, civilisation and enduring culture, Athens is a majestic and magical urban sprawl.

Explore Athens (Piraeus), Greece

Day by day

The full itinerary

23 scheduled calls
Oosterdam

Your ship

Oosterdam

Oosterdam, a Vista-class ship, recently emerged from dry dock with exciting updates—including completely refreshed suites and new lounge, dining and entertainment venues, such as Music Walk, with Lincoln Center Stage, B.B. King’s Blues Club and Billboard Onboard. Guests can choose from among delectable specialty restaurants, hone culinary skills with EXC Port to Table and thrill to BBC Earth Experiences.

5★ 82,305 GT 1,916 Passengers Built 2003
Oosterdam ship guide Search cruises on Oosterdam

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from $5,444 pp

via CruiseDirect

Book with CruiseDirect

Book direct with Holland America Line we may earn a commission