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Miami, Florida

65 nights · South America

65-night South America cruise from Miami, Florida on Sirena

The South American Adventure - Miami to Miami is a 65-night South America cruise aboard Sirena, operated by Oceania Cruises. Departing Miami, Florida on January 5, 2028, the voyage visits 33 ports including George Town, Cayman Islands, Ocho Rios, Santa Marta. Fares start from $22,699 per person.

Length
65 nights
Departs
Jan 5, 2028
Returns
Mar 10, 2028
Ports of call
33
Days at sea
31

Voyage code SIR280105C

from $22,699 pp

via CruiseDirect

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Why this route stands out

A closer look at the journey

Fixed editorial images from the places on this itinerary. They stay stable each time you return to this sailing.

Miami, Florida

Miami is called the gateway to the Americas, and it’s indeed a very glamourous global city to explore at the start or end of an MSC Caribbean and Antilles cruise. Home to many cultures, the city of Miami sizzles with flavours from the Americas, beginning with Cuba and the Little Havana neighbourhood - one of the most historically significant places, while Wynwood is famous for its wall art and Puerto Rican history. Across Biscayne Bay lies the city of Miami Beach, home to the world-famous South Beach. An MSC-arranged guided private tour opens up a world of possibilities for you: enjoy the beach, take in the city’s Art Deco architecture and enjoy a drink on legendary Ocean Drive, where you can people watch, and perhaps spot a celebrity. If time permits, take a stroll on artsy Lincoln Road packed with street side cafes and shops. Facing the MSC Cruises port in downtown Miami is Bayside Marketplace - a lively commercial centre that is a staging area for boat tours of Miami. Seeing the city from the water, with its impressive skyline and waterfront mansions, is an experience in itself. The downtown area also boasts the dazzling Performing Arts Centre, the Museum of Science, the Pérez Art Museum Miami (known as the PAMM), scenic Bayfront Park and the arena where the 3-time NBA champion Miami Heat basketball team plays. Miami is renowned for its shopping. Hop on a tour to see the major city sights followed by retail therapy at one of Miami's largest and newest shopping malls: Dolphin Mall. With more than 240 retail outlets, you’re bound to need a bit of room in your luggage for your purchases. Luckily, there are several luggage stores at the mall to fill that need. Head west past the city into untamed wilderness on an MSC excursion into the Everglades. At this national park where water is the central feature, unlike any other in North America, nature enthusiasts can hop on an airboat tour through the swampland and waterways to spot alligators and a variety of birds.

George Town, Cayman Islands

Christopher Columbus called the Cayman Islands, with their tranquil blue waters, "Las Tortugas" for its abundance of turtles. Located between Cuba and Jamaica, the Cayman Islands are comprised of three Caribbean islands: Grand Cayman, Little Cayman and Cayman Brac. Beautiful landscapes, bountiful wildlife and colourful streets embody this British Overseas Territory, with George Town, its capital, located on Grand Cayman, the largest and most populous island. When you arrive in George Town on an MSC Caribbean and Antilles cruise, you’ll discover that wildlife conservation is at the core of Grand Cayman’s offerings. For the chance of a lifetime to swim, feed and interact with stingrays, book an MSC excursion to Stingray City, where you’ll get an up-close experience with Cayman’s most graceful marine creatures. On yet another MSC excursion to the Cayman Turtle Centre, encounter the green turtles that return each and every year to lay their eggs on one of the beaches, visit the turtle hatchery, snorkel alongside yearlings in the Turtle Lagoon and meet the island’s endangered blue iguanas. For a special experience, ride horses bareback into the Caribbean Sea at Barker’s National Park on an exclusive Martha Stewart excursion curated just for MSC Cruises, followed by lunch at Vivo café, a spot beloved for its mostly vegan cuisine, with organic ingredients sourced straight from local farms. To learn about Cayman’s past and culture, explore Cayman Heritage House and visit the sumptuous Government House, the governor's residence built in 1964 located in front of Seven Mile Beach, one of the most prestigious beaches of Grand Cayman, in the heart of West Bay. Shopaholics will also delight in this destination. The Cayman Islands are entirely duty free. You just have to choose what catches your fancy among the myriad of watches, liqueurs, jewellery and porcelain on offer.

Santa Marta

Santa Marta, Colombia's first Spanish settlement, is the capital city of the Colombian department of Magdalena on the Caribbean Sea. It was founded in 1525 by the Spanish conqueror Rodrigo de Bastidas, which makes it the oldest remaining city in Colombia. Located northeast of Cartagena, between the Santa Marta Mountains and the Caribbean Sea, the city is a popular destination due to its history, colonial architecture, beaches and nearby nature reserves. The mountain range is second in height only to the Andes running through the country. Among the city's attractions include the grand hacienda where Simón Bolívar died in 1830. The recently renovated downtown of Santa Marta with its blend of colonial and Republican architecture is a highlight. The city has a new, distinctive international marina and broadwalk. Las Fiestas del Mar (The Festival of the Sea) is an annual celebration. The festival's slogan is Santa Marta, la magia de tenerlo todo ("Santa Marta, the magic of having it all"). Tayrona National Natural Park, north of Santa Marta, iis the most important ecological reserve in Colombia.

Price tracking

Today’s fare, in context

Price history

Cheaper than 89%
30 days
Fare details

Fare details

Per person · taxes & fees included
Current fares
Verified 15 hours ago
Inside
$22,699
Oceanview
$23,599
Balcony
$31,249
Tracked range
158 days
Price history by cabin type
CabinCurrentLowestHighest
Inside $22,699 $20,699 on Mar 25 $22,699 on Aug 12
Oceanview $23,599 $21,499 on Mar 25 $23,599 on Aug 12
Balcony $31,249 $28,649 on Mar 25 $33,449 on Aug 19
Suite $40,549 $39,449 on Apr 14 $42,599 on Jul 12
Cabin grades
16 total
Concierge VerandaBalcony · A1
Concierge VerandaBalcony · A2
Concierge VerandaBalcony · A3
Veranda StateroomBalcony · B1
Veranda StateroomBalcony · B2
Inside StateroomInside · F
Inside StateroomInside · G
Deluxe Ocean View StateroomOceanview · C1
Deluxe Ocean View StateroomOceanview · C2
Ocean View StateroomOceanview · D
Solo Oceanview StateroomOceanview · S
Owner's SuiteSuite · OS
Penthouse SuiteSuite · PH1
Penthouse SuiteSuite · PH2
Penthouse SuiteSuite · PH3
Vista SuiteSuite · VS

○ = last seen (sold out or delisted). · Verified 15 hours ago.

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Current prices

Per person · 2 guests · incl. taxes & fees

Inside

from $22,699

$349 / night

Fare rows

Inside Stateroom

Cabin grade

Available

from $22,699

$349 / night

per person · incl. taxes & fees

Oceanview

from $23,599

$363 / night

Fare rows

Ocean View Stateroom

Cabin grade

Available

from $23,599

$363 / night

per person · incl. taxes & fees

Deluxe Ocean View Stateroom

Cabin grade

Available

from $24,549

$377 / night

per person · incl. taxes & fees

Deluxe Ocean View Stateroom

Cabin grade

Available

from $25,649

$394 / night

per person · incl. taxes & fees

Balcony

from $31,249

$480 / night

Fare rows

Veranda Stateroom

Cabin grade

Available

from $31,249

$480 / night

per person · incl. taxes & fees

Suite

Not available

Prices verified Aug 28, 2026

Prices come from third-party data feeds via Oceania Cruises and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works

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The journey

65 nights, in order

Follow the entire sailing from its first day to its last, with the route and schedule in one view.

Miami, Florida

Day 1 Jan 5, 2028

Miami, Florida

Miami is called the gateway to the Americas, and it’s indeed a very glamourous global city to explore at the start or end of an MSC Caribbean and Antilles cruise.

Explore Miami, Florida

Day by day

The full itinerary

66 scheduled calls
Sirena

Your ship

Sirena

Elegant sister ship to charming Regatta, Insignia and Nautica, Oceania Cruises’ newest addition, Sirena embodies the most treasured elements of our celebrated fleet, and features a few highlights all her own. With the introduction of two culinary experiences, Sirena offers even more ways to savor The Finest Cuisine at Sea. Tuscan Steak, a new specialty restaurant, serves Italian favorites, succulent steaks and fresh seafood inspired by Toscana and Polo Grill. The Grand Dining Room offers a surprise transformation into The Bistro during lunch, which serves classic French fare as well as regional specialties and lunchtime favorites. Also featuring the beloved restaurant Red Ginger, Sirena invites you to enjoy bold Asian cuisine in a fresh new way.

5★ 30,277 GT 670 Passengers Adults Only
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Deck plan for Deck 3

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