17-night Western Mediterranean cruise: Genoa, Italy to Santos, Brazil on MSC Musica
The 17 nights South America from Genoa (Portofino) is a 17-night Western Mediterranean cruise aboard MSC Musica, operated by MSC Cruises. Departing Genoa, Italy on November 6, 2027 and arriving in Sao Paulo on November 23, 2027, the voyage visits 9 ports including Marseille, France, Valencia, Lisbon. Fares start from $1,623 per person.
Fixed editorial images from the places on this itinerary. They stay stable each time you return to this sailing.
Genoa, Italy
Genoa is marvellously eclectic, vibrant and full of rough-edged style; it’s a great cruise excursion.
Indeed “La Superba” (The Superb), as it was known at the height of its authority as a Mediterranean superpower, boasts more zest and intrigue than all the surrounding coastal resorts put together.
During a holiday to Genoa you can explore its old town: a dense and fascinating warren of medieval alleyways home to large palazzi built in the sixteenth and seventeenth centuries by Genoa’s wealthy mercantile families and now transformed into museums and art galleries. You should seek out the Cattedrale di San Lorenzo, the Palazzo Ducale, and the Renaissance palaces of Via Garibaldi which contain the cream of Genoa’s art collections, as well as furniture and decor from the grandest days of the city’s past, when its ships sailed to all corners of the Mediterranean Sea.
The Acquario di Genova is the city’s pride and joy, parked like a giant ocean liner on the waterfront, with seventy tanks housing sea creatures from all the world’s major habitats, including the world’s biggest reconstruction of a Caribbean coral reef. It’s a great aquarium by any standards, the second largest in Europe by capacity, and boasts a fashionably ecology-conscious slant and excellent background information in Italian and English.
Just 35 km south of Genoa, there’s no denying the appeal of Portofino, tucked into a protected inlet surrounded by lush cypress- and olive-clad slopes. It’s an A-list resort that has been attracting high-flying bankers, celebs and their hangers-on for years, as evidenced by the flotillas of giant yachts usually anchored just outside. It’s a tiny place that is attractive yet somehow off-putting at the same time, with a quota of fancy shops, bars and restaurants for a place twice its size.
Marseille, France
Marseille is the second largest city in France after Paris. It is also one of the oldest continuously inhabited cities in the Mediterranean. Cave paintings in the nearby Calanques are estimated to be 30,000 years old, and remains of brick habitations date from 6,000 BCE. The more recent history begins with a Hellenic port in about 600 BCE, some remains of which are on view at the city’s History Museum. It has been one of the world’s major seaports almost from its founding, and served as the main European terminus of the French colonial empire in Africa and the Far East. It is located in the Provence-Alpes-Cote d’Azur region and is the capital of the Bouches-du-Rhone department. On an island in the expansive bay of Marseille stands the prison of Chateau d’If made famous by the Alexandre Dumas novel “The Count of Monte Cristo.” The Vieux-Port with its atmospheric buildings and wharves is the area where visitors can search for the perfect example of the local specialty bouillabaisse, a rich fish stew containing at least three, and often more varieties of local fishes. Marseille’s newly renovated port at the venerable Joliette Docks is situated very close to the striking Cathédrale de la Major and the fascinating collections at the Museum of African, Oceanic and American Indian Arts.
Valencia
Valencia is Spain's third largest city and capital of the region. It was originally founded by the Romans on the banks of the river Turia in 138 BC. In 711 AD the Moors arrived and converted the area into a rich agricultural and industrial center, establishing ceramics, paper, silk and leather industries. Muslim rule was briefly interrupted in 1094 by the legendary Castillian knight, El Cid. Valencia boomed in the 15th and 16th centuries, becoming one of the strongest Mediterranean trading centers.
Valencia is a vibrant, friendly and chaotic city that boasts an outstanding fine arts museum and one of the most exciting nightlife scenes in Spain. The city center is about 3 miles inland from the coast. Plaza del Ayuntamiento marks the center of Valencia. Surrounded by flower stalls, it is also home to the town hall and the main post office. The cathedral was begun in the 13th century and finished in 1482. It has many architectural styles, including Gothic, Baroque and Romanesque. The octagonal bell-tower, called Miguelete, is one of the city's landmarks. The small cathedral museum boasts a tabernacle made from 550 pounds of gold, silver, platinum, emeralds and sapphires. It also purports to be the home of the Holy Grail, the cup used by Christ at the Last Supper.
West of the cathedral is the oldest part of the city, known as El Carme. Situated across the river in the Jardines del Real is the Museo de Bellas Artes, the Fine Arts Museum. Works include those by El Greco, Goya and Velázquez.
Prices come from third-party data feeds via MSC Cruises and may differ from the cruise line's current fare. Confirm the final price before booking. How our pricing works
Lowest fares with no residency, age, or service requirement — verify eligibility at booking. How our pricing works
Not ready to book?
Get price alerts
We’ll email you when fares drop or return.
Check your email to finish
We sent a confirmation link to your inbox. Your alert is not on yet — click that link to switch it on.
As soon as you step on board MSC Musica you are met by the stunning central foyer’s three-tier waterfall and it’s transparent piano, suspended above the water on a crystal floor. The designer venues on board are equally as stunning, whether you’re dancing to a band in the dazzling Crystal Lounge, enjoying a cigar in the stylish Havana Club cigar lounge, treating yourself to a wine tasting, trying your luck in the Sanremo Casino or enjoying a superb live show in the stunning La Scala Theatre.
The cuisine on the ship is all freshly prepared allowing you to indulge in Italian specialities in Il Giardino, treat yourself at the Kaito Sushi Bar or work your way through a range of delicious, authentic Italian pizzas.
Children and young adults enjoy special treatment with indoor and outdoor play areas, a pool of their own and separate Kids and Teens Clubs for their own social life on board.
We count visits anonymously without cookies. Accept cookies to let us remember you across visits and connect activity if you create an account, or decline and we'll still count you anonymously. Read our privacy policy
ESC
The Captain
I'm the Captain. Tell me what you're after — "Caribbean under $2,000" or "7 nights from Miami" — and I'll find the sailing and its price history.