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12-night Asia & Indian Ocean cruise: Ho Chi Minh City to Siem Reap on Mekong Serenity

The Vietnam & Cambodia Highlights from Ho Chi Minh City is a 12-night Asia & Indian Ocean cruise aboard Mekong Serenity, operated by APT Cruising. Departing Ho Chi Minh City on April 9, 2028 and arriving in Siem Reap on April 21, 2028, the voyage visits 11 ports including My Tho, Cai Be, Sa Dec. CruiseCaptain has fare history for this sailing.

Length
12 nights
Departs
Apr 9, 2028
Returns
Apr 21, 2028
Ports of call
11
Days at sea
1

Voyage code VEMR13

Ho Chi Minh City

12 nights · Asia & Indian Ocean

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Why this route stands out

A closer look at the journey

Ho Chi Minh City

Ho Chi Minh City is a vibrant port of call for MSC cruise liners on MSC Grand Voyages cruise itineraries. It’s a fury of sights and sounds, and the crucible in which Vietnam’s rallying fortunes are boiling. Few corners of the city afford respite from the cacophony of construction work casting up new office blocks and hotels with logic-defying speed. An increasing number of cars and minibuses jostle with an organic mass of state-of-the-art Honda SUVs, choking the tree-lined streets and boulevards. Amid this melee, the local people go about their daily life: smartly dressed schoolkids wander past streetside baguette-sellers; women shoppers ride motorbikes clad in gangster-style bandanas to protect their skin from the sun and dust; while teenagers in designer jeans chirrup into mobile phones. MSC Cruises shore excursions can be a clever option to see much of Ho Chi Minh City’s fun that derives from the simple pleasure of absorbing its flurry of activity – something best done from the seat of a cyclo or a roadside café. To blink is to miss some new and singular sight, be it a motorbike stacked high with piglets bound for the market, or a boy on a bicycle rapping out a staccato tattoo on pieces of bamboo to advertise noodles for sale. For some visitors, the American war is their primary frame of reference and such historical hot spots as the Reunification Palace rank highly on their itineraries. In addition, ostentatious reminders of French rule abound, among them such memorable buildings as Notre Dame Cathedral and the grandiose Hotel de Ville – but even these look spanking-new when compared to gloriously musty edifices like Quan Am Pagoda and the Jade Emperor Pagoda, just a couple of the many captivating places of worship across the city. And don’t miss Ben Thanh Market, the teeming Vietnamese market par excellence, check the city’s pulse here on an early morning stroll.

Tan Chau

Tân Châu is a town of An Giang Province in the Mekong Delta region of Vietnam. As of 2009 the town had a population of 184,129. The town covers an area of 175.68 km². It is famous for Tân Châu silk with the famous product Lãnh Mỹ A, whose black colour comes from the Diospyros mollis's fruit.

Phnom Penh

Phnom Penh, Cambodia’s busy capital, sits at the junction of the Mekong and Tonlé Sap rivers. It was a hub for both the Khmer Empire and French colonialists. On its walkable riverfront, lined with parks, restaurants and bars, are the ornate Royal Palace, Silver Pagoda and the National Museum, displaying artifacts from around the country. At the city’s heart is the massive, art deco Central Market.

Price tracking

Today’s fare, in context

Show all 8 cabin grades
Cabin grades and pricing
Name Supplier code Type
Deluxe Twin Balcony Suite A Suite
Angkor Suite ANG Suite
Deluxe Twin Balcony Suite B Suite
Bayon Suites BAY Suite
Deluxe Twin Balcony Suite C Suite
Deluxe Twin Balcony Suite D Suite
Deluxe Twin Balcony Suite E Suite
Deluxe Twin Balcony Suite EE Suite

Current prices

Per person · 2 guests · incl. taxes & fees

Price information is not available.

This sailing

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The journey

12 nights, in order

Ho Chi Minh City

Day 1 Apr 9, 2028

Ho Chi Minh City

Ho Chi Minh City is a vibrant port of call for MSC cruise liners on MSC Grand Voyages cruise itineraries.

Explore Ho Chi Minh City

Day by day

The full itinerary

28 scheduled calls
Mekong Serenity

Your ship

Mekong Serenity

The brand new ship on the Mekong River, the enchanting Mekong Serenity provides a spacious retreat to truly enjoy the lush landscapes of Vietnam and Cambodia. With a large amount of space per guest, this luxurious vessel boasts some of the largest suites on the Mekong. With just 44 suites accompanying a maximum of 88 guests, its intimate size means your voyage is highly personalised. Showcasing a modern sophisticated style with a nod to colonial times, this is a ship beyond compare.

5★ 88 Passengers Built 2021
Mekong Serenity ship guide Search cruises on Mekong Serenity

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More ways to take this journey

Other sailing dates

Same itinerary, different departure dates.

Prices per person, incl. taxes & fees

Departs

Sep 13, 2026

Voyage VEMR13

from $12,190

$1,015 / night

View sailing

Departs

Oct 25, 2026

Voyage VEMR13

from $13,890

$1,157 / night

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See all 12 sailing dates

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Continues on APT Cruising's site

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